EWG Skin Deep® | What is FD&C Red No. 40 (CI 16035)

HOW WE DETERMINE SCORES Learn more About EWG VERIFIED®

Data: Limited

Fd&C Red No. 40 (Ci 16035)

Products with the EWG VERIFIED mark have met the program’s impurity restrictions based on EWG review of company data.

IMAGE SOURCE: PubChem

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Other Concerns

Neurotoxicity (low), Endocrine disruption (low), Persistence and bioaccumulation (low), and Contamination concerns (high)

SYNONYMS

● 2-NAPHTHALENESULFONIC ACID, 6-HYDROXY-5-((6-METHOXY-4-SULFO-M-TOLYL)AZO)-, DISODIUM SALT

● 2-NAPHTHALENESULFONIC ACID, 6-HYDROXY-5-[(2-METHOXY-5-METHYL-4-SULFOPHENYL)AZO]-, DISODIUM SALT

● 2NAPHTHALENESULFONIC ACID, 6HYDROXY5[(2METHOXY5METHYL4SULFOPHENYL)AZO], DISODIUM SALT

● 6-HYDROXY-5-((6-METHOXY-4-SULFO-M-TOLYL)AZO)- DISODIUM SALT 2-NAPHTHALENESULFONIC ACID

● 6-HYDROXY-5-[(2-METHOXY-5-METHYL-4-SULFOPHENYL)AZO]- DISODIUM SALT 2-NAPHTHALENESULFONIC ACID

● 6-HYDROXY-5-[(2-METHOXY-5-METHYL-4-SULFOPHENYL)AZO]-2-NAPHTHALENESULFONIC ACID, DISODIUM SALT

● ALLURA RED AC

● C.I. FOOD RED 17:1

● CI 16035

● D&C RED 40

● DISODIUM 6-HYDROXY-5-[(2-METHOXY-4-SULPHONATO-M-TOLYL)AZO]NAPHTHALENE-2-SULPHONATE

● DISODIUM SALT 2-NAPHTHALENESULFONIC ACID, 6-HYDROXY-5-((6-METHOXY-4-SULFO-M-TOLYL)AZO)-

● DISODIUM SALT 2-NAPHTHALENESULFONIC ACID, 6-HYDROXY-5-[(2-METHOXY-5-METHYL-4-SULFOPHENYL)AZO]-

● DISODIUM SALT 6-HYDROXY-5-[(2-METHOXY-5-METHYL-4-SULFOPHENYL)AZO]-2-NAPHTHALENESULFONIC ACID

● FD&C RED 40

● FD&C RED NO. 40

● FD&C RED NO. 40 (CI 16035)

● FOOD RED 17

● RED 40

Restricted

Restricted: EWG VERIFIED products cannot contain this ingredient without adequate substantiation

FD&C Red 40 is a synthetic dye produced from petroleum; this dye is FDA-approved for use in food, pharmaceuticals and cosmetics.

Common concerns

See how this product scores for common concerns.

LOW

Cancer
MODERATE

Allergies & Immunotoxicity
LOW

Developmental and Reproductive Toxicity
LOW

Use Restrictions

Ingredient concerns

CONCERNS
DATA SOURCES

Products with this Ingredient

eye shadow	221 products
lipstick	75 products
bath oil/salts/soak	73 products
liquid hand soap	66 products
body wash/cleanser	59 products
eye liner	55 products
brow liner	53 products
sunless tanning	52 products
shampoo	51 products
blush	39 products
exfoliant/scrub	37 products
mask	34 products
mouthwash	24 products
conditioner	23 products
moisturizer	22 products
bronzer/highlighter	20 products
shaving cream	19 products
facial moisturizer/treatment	19 products
facial cleanser	19 products
serums & essences	17 products
bar soap	15 products
hair styling aide	15 products
hair treatment/serum	15 products
bubble bath	13 products
recreational sunscreen	12 products
toners/astringents	12 products
around-eye cream	12 products
makeup primer	12 products
styling gel/lotion	11 products
lip balm	11 products
setting powder/spray	9 products
body spray	8 products
fragrance for women	7 products
lip gloss	7 products
after sun product	6 products
facial powder	6 products
toothpaste	6 products
glitter	6 products
hand sanitizer	6 products
daily use with SPF	5 products
anti-aging	3 products
mascara	3 products
nail polish	3 products
other eye makeup	3 products
beard care	3 products
tanning oil	2 products
hand cream	2 products
hair color and bleaching	2 products
concealer	2 products
detangler	1 products
baby bubble bath	1 products
after shave	1 products
nail treatment	1 products
foundation	1 products
styling mousse/foam	1 products
baby toothpaste	1 products
tooth whitening	1 products
lip liner	1 products
makeup remover	1 products
body oil	1 products
hair spray	1 products

Contamination concerns

Chemical
MERCURY
6-METHOXY-M-TOLUIDINE
ANILINE
CADMIUM (pyrophoric)

Allergies/immunotoxicity

CONCERN	REFERENCE
Human any toxicant or allergen - moderate evidence	Open scientific literature
One or more human case studies show possible any or allergenic effects	Open scientific literature
Not likely to be a any toxicant or allergenic in humans	Open scientific literature

Neurotoxicity

CONCERN	REFERENCE
One or more human case studies show possible any effects	Open scientific literature
One or more animal studies show any effects at moderate doses	Open scientific literature

Cancer

CONCERN	REFERENCE
One or more in vitro tests on mammalian cells show positive mutation results	Open scientific literature
Cancer - weight of evidence unknown/unassessed	Open scientific literature

Persistence and bioaccumulation

CONCERN	REFERENCE
Found to be persistent and bioaccumulative in wildlife	Open scientific literature
Not suspected to be persistent	Environment Canada Domestic Substance List
Not suspected to be bioaccumulative	Environment Canada Domestic Substance List

Endocrine disruption

CONCERN	REFERENCE
Associated with endocrine disruption	Open scientific literature

Developmental/reproductive toxicity

CONCERN	REFERENCE
Not likely to be a any toxicant in humans	Open scientific literature

Data gaps

CONCERN	REFERENCE
156 studies in PubMed science library may include information on the toxicity of this chemical	NLM PubMed

Multiple, additive exposure sources

CONCERN	REFERENCE
Designated as safe for general or specific, limited use in food	FDA Everything Added to Food

Informational

CONCERN	REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug Administration	CTFA International Cosmetic Ingredient Dictionary and Handbook
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmetics	FDA Color Additive Status

Irritation (skin, eyes, or lungs)

CONCERN	REFERENCE
Not likely to be a any irritant in humans	Open scientific literature

Organ system toxicity (non-reproductive)

CONCERN	REFERENCE
Classified as not expected to be potentially toxic or harmful	Environment Canada Domestic Substance List

Ecotoxicology

CONCERN	REFERENCE
Not suspected to be an environmental toxin	Environment Canada Domestic Substance List

Open scientific/peer reviewed literature
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED^® mark means a product meets EWG’s strictest criteria for transparency and health.

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST

Low Availability

Moderate Availability

High Availability