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Data: Limited

Fd&C Red No. 40 (Ci 16035)

  • Products with the EWG VERIFIED mark have met the program’s impurity restrictions based on EWG review of company data.

IMAGE SOURCE: PubChem

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Other Concerns

Neurotoxicity (low), Endocrine disruption (low), Persistence and bioaccumulation (low), and Contamination concerns (high)

SYNONYMS

2-NAPHTHALENESULFONIC ACID, 6-HYDROXY-5-((6-METHOXY-4-SULFO-M-TOLYL)AZO)-, DISODIUM SALT, 2-NAPHTHALENESULFONIC ACID, 6-HYDROXY-5-[(2-METHOXY-5-METHYL-4-SULFOPHENYL)AZO]-, DISODIUM SALT, 2NAPHTHALENESULFONIC ACID, 6HYDROXY5[(2METHOXY5METHYL4SULFOPHENYL)AZO], DISODIUM SALT, 6-HYDROXY-5-((6-METHOXY-4-SULFO-M-TOLYL)AZO)- DISODIUM SALT 2-NAPHTHALENESULFONIC ACID, 6-HYDROXY-5-[(2-METHOXY-5-METHYL-4-SULFOPHENYL)AZO]- DISODIUM SALT 2-NAPHTHALENESULFONIC ACID, 6-HYDROXY-5-[(2-METHOXY-5-METHYL-4-SULFOPHENYL)AZO]-2-NAPHTHALENESULFONIC ACID, DISODIUM SALT, ALLURA RED AC, C.I. FOOD RED 17:1, CI 16035, D&C RED 40, DISODIUM 6-HYDROXY-5-[(2-METHOXY-4-SULPHONATO-M-TOLYL)AZO]NAPHTHALENE-2-SULPHONATE, DISODIUM SALT 2-NAPHTHALENESULFONIC ACID, 6-HYDROXY-5-((6-METHOXY-4-SULFO-M-TOLYL)AZO)-, DISODIUM SALT 2-NAPHTHALENESULFONIC ACID, 6-HYDROXY-5-[(2-METHOXY-5-METHYL-4-SULFOPHENYL)AZO]-, DISODIUM SALT 6-HYDROXY-5-[(2-METHOXY-5-METHYL-4-SULFOPHENYL)AZO]-2-NAPHTHALENESULFONIC ACID, FD&C RED 40, FD&C RED NO. 40, FD&C RED NO. 40 (CI 16035), FOOD RED 17, and RED 40

Restricted

Restricted: EWG VERIFIED products cannot contain this ingredient without adequate substantiation

FD&C Red 40 is a synthetic dye produced from petroleum; this dye is FDA-approved for use in food, pharmaceuticals and cosmetics.

Common concerns

See how this product scores for common concerns.

  • LOW
    Cancer
  • MODERATE
    Allergies & Immunotoxicity
  • LOW
    Developmental and Reproductive Toxicity
  • LOW
    Use Restrictions

Ingredient concerns

  • CONCERNS
  • DATA SOURCES

Products with this Ingredient

Expand content Collapse content
eye shadow179 products
bath oil/salts/soak79 products
lipstick75 products
liquid hand soap73 products
body wash/cleanser56 products
eye liner55 products
brow liner51 products
sunless tanning44 products
shampoo34 products
blush30 products
exfoliant/scrub30 products
mask25 products
bronzer/highlighter24 products
mouthwash22 products
shaving cream20 products
facial cleanser18 products
conditioner17 products
bar soap17 products
serums & essences17 products
moisturizer16 products
facial moisturizer/treatment15 products
bubble bath14 products
around-eye cream14 products
lip gloss13 products
toners/astringents12 products
makeup primer11 products
recreational sunscreen10 products
hair styling aide9 products
body spray9 products
toothpaste9 products
hair treatment/serum8 products
hand sanitizer8 products
lip balm8 products
setting powder/spray8 products
styling gel/lotion8 products
fragrance for women7 products
glitter6 products
facial powder6 products
after sun product5 products
daily use with SPF4 products
beard care3 products
mascara3 products
other eye makeup3 products
nail polish3 products
anti-aging3 products
hand cream2 products
concealer2 products
makeup remover2 products
baby bubble bath1 products
tooth whitening1 products
baby toothpaste1 products
foundation1 products
body art1 products
hair removal waxes1 products
nail treatment1 products
body oil1 products
lip liner1 products
detangler1 products
after shave1 products

Contamination concerns

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Chemical
MERCURY
6-METHOXY-M-TOLUIDINE
ANILINE
CADMIUM (pyrophoric)

Allergies/immunotoxicity

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CONCERN REFERENCE
Human any toxicant or allergen - moderate evidenceOpen scientific literature
One or more human case studies show possible any or allergenic effectsOpen scientific literature
Not likely to be a any toxicant or allergenic in humansOpen scientific literature

Neurotoxicity

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CONCERN REFERENCE
One or more human case studies show possible any effectsOpen scientific literature
One or more animal studies show any effects at moderate dosesOpen scientific literature

Cancer

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CONCERN REFERENCE
One or more in vitro tests on mammalian cells show positive mutation resultsOpen scientific literature
Cancer - weight of evidence unknown/unassessedOpen scientific literature

Persistence and bioaccumulation

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CONCERN REFERENCE
Found to be persistent and bioaccumulative in wildlifeOpen scientific literature
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Endocrine disruption

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CONCERN REFERENCE
Associated with endocrine disruptionOpen scientific literature

Developmental/reproductive toxicity

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CONCERN REFERENCE
Not likely to be a any toxicant in humansOpen scientific literature

Data gaps

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CONCERN REFERENCE
156 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Multiple, additive exposure sources

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CONCERN REFERENCE
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Informational

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CONCERN REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmeticsFDA Color Additive Status

Irritation (skin, eyes, or lungs)

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CONCERN REFERENCE
Not likely to be a any irritant in humansOpen scientific literature

Organ system toxicity (non-reproductive)

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CONCERN REFERENCE
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Ecotoxicology

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CONCERN REFERENCE
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List
  • Open scientific/peer reviewed literature
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend
WEIGHT-OF-EVIDENCE APPROACH

A product’s hazard score is not an average of the ingredients’ hazard scores. It is calculated using a weight-of-evidence approach that factors in all of the hazards or health impacts associated with the ingredients.

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST
Low Availability
Moderate Availability
High Availability
NONE

Ingredients have not been assessed.

LIMITED-FAIR

There is only a modest volume of research.

GOOD-ROBUST

Ingredients have been studied extensively.

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