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FD&C Red No. 4 (CI 14700)
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (high) and Endocrine disruption (low)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| liquid hand soap | 109 products |
| fragrance for women | 81 products |
| body wash/cleanser | 69 products |
| bath oil/salts/soak | 62 products |
| bar soap | 61 products |
| body spray | 39 products |
| facial moisturizer/treatment | 38 products |
| moisturizer | 33 products |
| shampoo | 32 products |
| exfoliant/scrub | 31 products |
| mask | 26 products |
| sunless tanning | 21 products |
| fragrance for men | 20 products |
| hand sanitizer | 19 products |
| conditioner | 18 products |
| hair styling aide | 18 products |
| bubble bath | 16 products |
| facial cleanser | 16 products |
| toners/astringents | 12 products |
| hair color and bleaching | 11 products |
| daily use with SPF | 8 products |
| serums & essences | 8 products |
| hair treatment/serum | 8 products |
| nail polish | 5 products |
| styling gel/lotion | 5 products |
| hand cream | 5 products |
| bronzer/highlighter | 4 products |
| makeup primer | 4 products |
| body firming lotion | 3 products |
| after shave | 3 products |
| antiperspirant/deodorant (men's) | 2 products |
| setting powder/spray | 2 products |
| foot odor control | 2 products |
| makeup remover | 2 products |
| styling mousse/foam | 2 products |
| recreational sunscreen | 1 products |
| beard oil | 1 products |
| shaving cream | 1 products |
| shaving cream (men's) | 1 products |
| foot cleansing | 1 products |
| baby bubble bath | 1 products |
| anti-aging | 1 products |
| around-eye cream | 1 products |
| antiperspirant/deodorant | 1 products |
| hair relaxer | 1 products |
Use restrictions
| Concern | Reference |
|---|---|
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | CosIng |
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | CTFA International Cosmetic Ingredient Dictionary and Handbook |
| Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive approved by FDA for use in cosmetics: external use only | FDA Color Additive Status |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any | CosIng |
Cancer
| Concern | Reference |
|---|---|
| One or more in vitro tests on mammalian cells show positive mutation results | Open scientific literature |
| Not likely to be mutagenic in humans | Open scientific literature |
| Not likely to be carcinogenic in humans | Open scientific literature |
| Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gaps | Int'l Agency for Research on Cancer (IARC) - Carcinogens |
Endocrine disruption
| Concern | Reference |
|---|---|
| Associated with endocrine disruption | Open scientific literature |
Informational
| Concern | Reference |
|---|---|
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - The substance was formerly approved as a food additive but is now banned; there may be some toxicology data available. | FDA Everything Added to Food |
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug Administration | CTFA International Cosmetic Ingredient Dictionary and Handbook |
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmetics: external use only | FDA Color Additive Status |
Data gaps
| Concern | Reference |
|---|---|
| 74 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
| Concern | Reference |
|---|---|
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Not suspected to be persistent | Environment Canada Domestic Substance List |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
- European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
- FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
- Open scientific/peer reviewed literature
- IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
- FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
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