EWG Skin Deep® | What is FD&C Red No. 4 (CI 14700)

HOW WE DETERMINE SCORES Learn more About EWG VERIFIED™

Data: Fair

Fd&C Red No. 4 (Ci 14700)

IMAGE SOURCE: PubChem

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Other Concerns

Use restrictions (high) and Endocrine disruption (low)

SYNONYMS

● 1-NAPHTHALENESULFONIC ACID, 3-[(2,4-DIMETHYL-5-SULFOPHENYL)AZO]-4-HYDROXY-, DISODIUM SALT

● 1NAPHTHALENESULFONIC ACID, 3[(2,4DIMETHYL5SULFOPHENYL)AZO]4HYDROXY, DISODIUM SALT

● 3-[(2,4-DIMETHYL-5-SULFOPHENYL)AZO]-4-HYDROXY- DISODIUM SALT 1-NAPHTHALENESULFONIC ACID

● 3-[(2,4-DIMETHYL-5-SULFOPHENYL)AZO]-4-HYDROXY-1-NAPHTHALENESULFONIC ACID, DISODIUM SALT

● AKA504

● CI 14700

● D&C RED 4

● DISODIUM 3-[(2,4-DIMETHYL-5-SULPHONATOPHENYL)AZO]-4-HYDROXYNAPHTHALENE-1-SULPHONATE

● DISODIUM SALT 1-NAPHTHALENESULFONIC ACID, 3-[(2,4-DIMETHYL-5-SULFOPHENYL)AZO]-4-HYDROXY-

● DISODIUM SALT 3-[(2,4-DIMETHYL-5-SULFOPHENYL)AZO]-4-HYDROXY-1-NAPHTHALENESULFONIC ACID

● FD&C RED 4

● FD&C RED NO. 4

● FD&C RED NO. 4 (CI 14700)

● FOOD RED 1

● RED 4

● RED 504

● RED NO. 504

Unacceptable

Unacceptable: EWG VERIFIED products cannot contain this ingredient

FD&C Red 4 is a synthetic dye produced from petroleum; this dye is FDA-approved for use in food, pharmaceuticals and cosmetics.

Common concerns

See how this product scores for common concerns.

LOW

Cancer
LOW

Allergies & Immunotoxicity
LOW

Developmental and Reproductive Toxicity
HIGH

Use Restrictions

Ingredient concerns

CONCERNS
DATA SOURCES

Products with this Ingredient

liquid hand soap	99 products
fragrance for women	95 products
body wash/cleanser	60 products
bath oil/salts/soak	59 products
exfoliant/scrub	41 products
shampoo	39 products
facial moisturizer/treatment	37 products
bar soap	33 products
moisturizer	32 products
body spray	28 products
sunless tanning	27 products
mask	21 products
conditioner	20 products
hand sanitizer	20 products
fragrance for men	17 products
hair treatment/serum	13 products
hand cream	12 products
facial cleanser	12 products
bubble bath	11 products
serums & essences	9 products
hair styling aide	9 products
styling gel/lotion	9 products
setting powder/spray	9 products
hair color and bleaching	6 products
daily use with SPF	6 products
toners/astringents	5 products
lipstick	5 products
blush	4 products
bronzer/highlighter	3 products
makeup primer	3 products
foot moisturizer	3 products
nail polish	3 products
body firming lotion	3 products
shaving cream	2 products
after shave	2 products
lip balm	2 products
cuticle treatment	1 products
antiperspirant/deodorant	1 products
recreational sunscreen	1 products
around-eye cream	1 products
nail treatment	1 products
antiperspirant/deodorant (men's)	1 products
styling mousse/foam	1 products
makeup remover	1 products

Use restrictions

CONCERN	REFERENCE
Violation of government restrictions - Banned or found unsafe for use in cosmetics	CosIng
Violation of government restrictions - Banned or found unsafe for use in cosmetics	CTFA International Cosmetic Ingredient Dictionary and Handbook
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive approved by FDA for use in cosmetics: external use only	FDA Color Additive Status
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any	CosIng

Cancer

CONCERN	REFERENCE
One or more in vitro tests on mammalian cells show positive mutation results	Open scientific literature
Not likely to be mutagenic in humans	Open scientific literature
Not likely to be carcinogenic in humans	Open scientific literature
Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gaps	Int'l Agency for Research on Cancer (IARC) - Carcinogens

Endocrine disruption

CONCERN	REFERENCE
Associated with endocrine disruption	Open scientific literature

Informational

CONCERN	REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - The substance was formerly approved as a food additive but is now banned; there may be some toxicology data available.	FDA Everything Added to Food
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug Administration	CTFA International Cosmetic Ingredient Dictionary and Handbook
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmetics: external use only	FDA Color Additive Status

Data gaps

CONCERN	REFERENCE
74 studies in PubMed science library may include information on the toxicity of this chemical	NLM PubMed

Ecotoxicology

CONCERN	REFERENCE
Not suspected to be an environmental toxin	Environment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

CONCERN	REFERENCE
Classified as not expected to be potentially toxic or harmful	Environment Canada Domestic Substance List

Persistence and bioaccumulation

CONCERN	REFERENCE
Not suspected to be persistent	Environment Canada Domestic Substance List
Not suspected to be bioaccumulative	Environment Canada Domestic Substance List

European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
Open scientific/peer reviewed literature
IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

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