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FD&C RED 28

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Endocrine disruption (low), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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nail polish19 products
bath oil/salts/soak6 products
bar soap3 products
lipstick2 products
blush2 products
exfoliant/scrub1 products
moisturizer1 products
lip balm with SPF1 products

Use restrictions

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Concern Reference
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - anyUS. Food and Drug Administration (FDA). 2015. Color Additive Status. Appears as: listid: COLOR-121; Chemical_Name: D&C Red 28; ;

Persistence and bioaccumulation

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Concern Reference
Persistent, bioaccumulative in wildlifeEnvironment Canada 2015. Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET). Appears as: listid: PBT-CANADA-477; Chemical_Name: BENZOIC ACID, 2,3,4,5TETRACHLORO6(2,4,5,7TETRABROMO6HYDROXY3OXO3HXANTHEN9YL); ; CAS: 2134-15-8

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-04548; Chemical_Name: Benzoic acid, 2,3,4,5-tetrachloro-6-(2, 4,5,7-tetrabromo-6-hydroxy-3-oxo-3H-xanthen-9-yl) -; ; CAS: 2134-15-8

Irritation (skin, eyes, or lungs)

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Concern Reference
Limited evidence of eye irritationEuropean Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website
One or more animal studies show any irritation at high dosesScientific Committee on Consumer Safety (SCCS) 2012. Opinion on Acid Red 92.

Cancer

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Concern Reference
Cancer - weight of evidence unknown/unassessedScientific Committee on Consumer Safety (SCCS) 2012. Opinion on Acid Red 92.

Developmental/reproductive toxicity

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Concern Reference
any - weight of evidence unknown/unassessedScientific Committee on Consumer Safety (SCCS) 2012. Opinion on Acid Red 92.

Ecotoxicology

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Concern Reference
Suspected to be an environmental toxin and be persistent or bioaccumulativeEnvironment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-04548; Chemical_Name: Benzoic acid, 2,3,4,5-tetrachloro-6-(2, 4,5,7-tetrabromo-6-hydroxy-3-oxo-3H-xanthen-9-yl) -; ; CAS: 2134-15-8
Suspected to be an environmental toxinEnvironment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-04548; Chemical_Name: Benzoic acid, 2,3,4,5-tetrachloro-6-(2, 4,5,7-tetrabromo-6-hydroxy-3-oxo-3H-xanthen-9-yl) -; ; CAS: 2134-15-8

Endocrine disruption

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Concern Reference
Associated with endocrine disruptionNational Toxicology Program (NTP) 2020. EWG Toxcast Analysis. Appears as: CAS: 13473-26-2; Chemical_Name: AKA218

Data gaps

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Concern Reference
22 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook

Data Sources

  • US. Food and Drug Administration (FDA). 2015. Color Additive Status. Appears as: listid: COLOR-121; Chemical_Name: D&C Red 28; ;
  • Environment Canada 2015. Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET). Appears as: listid: PBT-CANADA-477; Chemical_Name: BENZOIC ACID, 2,3,4,5TETRACHLORO6(2,4,5,7TETRABROMO6HYDROXY3OXO3HXANTHEN9YL); ; CAS: 2134-15-8
  • Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-04548; Chemical_Name: Benzoic acid, 2,3,4,5-tetrachloro-6-(2, 4,5,7-tetrabromo-6-hydroxy-3-oxo-3H-xanthen-9-yl) -; ; CAS: 2134-15-8
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website
  • Scientific Committee on Consumer Safety (SCCS) 2012. Opinion on Acid Red 92.
  • National Toxicology Program (NTP) 2020. EWG Toxcast Analysis. Appears as: CAS: 13473-26-2; Chemical_Name: AKA218
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.

About this Ingredient's Score Range

  • Products with the EWG VERIFIED mark have met use restrictions and warnings based on EWG review of company data.

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