Menu Close Menu

Menu

CI 42090 (FD&C Blue No. 1 or D&C Blue No. 4)

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Neurotoxicity (low), Endocrine disruption (low), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), Multiple, additive exposure sources (low), Irritation (skin, eyes, or lungs) (moderate), and Contamination concerns (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

Expand content Collapse content
body wash/cleanser391 products
lipstick341 products
liquid hand soap227 products
shampoo182 products
bath oil/salts/soak179 products
toothpaste133 products
conditioner118 products
nail polish116 products
lip gloss112 products
eye liner109 products
eye shadow102 products
mask96 products
mouthwash82 products
hand sanitizer80 products
bar soap69 products
facial cleanser66 products
exfoliant/scrub63 products
fragrance for women59 products
brow liner54 products
moisturizer47 products
facial moisturizer/treatment43 products
sunless tanning41 products
fragrance for men40 products
hair styling aide39 products
styling gel/lotion38 products
bubble bath37 products
after sun product34 products
body spray33 products
shaving cream32 products
lip balm31 products
antiperspirant/deodorant (men's)29 products
toners/astringents27 products
hair treatment/serum27 products
hair color and bleaching26 products
glitter25 products
shaving cream (men's)19 products
lip liner18 products
serums & essences18 products
antiperspirant/deodorant17 products
blush15 products
makeup primer14 products
after shave13 products
makeup remover12 products
around-eye cream11 products
body firming lotion10 products
bronzer/highlighter9 products
setting powder/spray9 products
9 products
tooth whitening8 products
hand cream8 products
concealer8 products
lip plumper8 products
foot cleansing7 products
recreational sunscreen7 products
polish remover6 products
mascara6 products
daily use with SPF6 products
foot moisturizer5 products
hair-loss treatment4 products
baby bubble bath4 products
beard care4 products
hair spray3 products
facial powder3 products
other eye makeup3 products
beard cleanser3 products
nail treatment2 products
muscle/joint soreness2 products
baby shampoo2 products
eye makeup remover1 products
foundation1 products
vapor rubs1 products
hair relaxer1 products
oil controller1 products
foot odor control1 products
styling mousse/foam1 products
cuticle treatment1 products
body art1 products
BB cream1 products
baby toothpaste1 products
body oil1 products
tanning oil1 products
baby oil1 products
damaged skin treatment1 products

Contamination concerns

Expand content Collapse content

Use restrictions

Expand content Collapse content
Concern Reference
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive approved by FDA for use in cosmetics: external use onlyFDA Color Additive Status
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - anyCosIng

Persistence and bioaccumulation

Expand content Collapse content
Concern Reference
Persistent or bioaccumulative and moderate to high toxicity concern in humansEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

Expand content Collapse content
Concern Reference
Classified as medium human health priorityEnvironment Canada Domestic Substance List
One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Toxic Release Inventory PBTs
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Irritation (skin, eyes, or lungs)

Expand content Collapse content
Concern Reference
Limited evidence of any irritationOpen scientific literature

Multiple, additive exposure sources

Expand content Collapse content
Concern Reference
Used in food or as an additive with limited or no toxicity information availableOpen scientific literature
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Neurotoxicity

Expand content Collapse content
Concern Reference
One or more animal studies show any effects at moderate dosesOpen scientific literature
One or more in vitro tests on mammalian cells demonstrate neurotoxicityOpen scientific literature

Endocrine disruption

Expand content Collapse content
Concern Reference
Associated with endocrine disruptionOpen scientific literature

Cancer

Expand content Collapse content
Concern Reference
One or more in vitro tests on cells show inconclusive, but potentially positive mutation resultsOpen scientific literature
Not likely to be mutagenic in humansOpen scientific literature
Not likely to be carcinogenic in humansOpen scientific literature
Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gapsInt'l Agency for Research on Cancer (IARC) - Carcinogens

Informational

Expand content Collapse content
Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmeticsFDA Color Additive Status
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook

Ecotoxicology

Expand content Collapse content
Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

Expand content Collapse content
Concern Reference
477 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Developmental/reproductive toxicity

Expand content Collapse content
Concern Reference
Not likely to be a reproductive or developmental toxinOpen scientific literature

Data Sources

  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
  • Open scientific/peer reviewed literature
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
  • IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products intended for damaged skin due to increased risk of absorption.
  • This ingredient’s score is higher if used in products intended for use around mouth due to increased risk of ingestion and absorption.
  • This ingredient’s score is higher if used in products intended for use on lips due to increased risk of ingestion and absorption.
  • This ingredient’s score is higher if used in products intended for use around the eyes due to increased risk of absorption.
  • Products with the EWG VERIFIED mark have met the program’s impurity and use restrictions based on EWG's review of the company's data.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

ABOUT EWG VERIFIED™

Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer