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EUGENOL

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (moderate) and Non-reproductive organ system toxicity (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is HIGH

Products with this Ingredient

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fragrance for women92 products
fragrance for men57 products
facial moisturizer/treatment39 products
serums & essences29 products
lipstick29 products
moisturizer26 products
lip gloss24 products
hair treatment/serum24 products
lip balm23 products
shampoo21 products
hair spray18 products
hair styling aide18 products
conditioner17 products
styling gel/lotion16 products
body wash/cleanser16 products
body firming lotion15 products
hand cream12 products
bath oil/salts/soak12 products
hair color and bleaching11 products
antiperspirant/deodorant10 products
body spray10 products
facial cleanser9 products
body oil9 products
mask9 products
exfoliant/scrub8 products
around-eye cream8 products
daily use with SPF7 products
bar soap6 products
liquid hand soap5 products
5 products
bronzer/highlighter5 products
antiperspirant/deodorant (men's)5 products
foundation5 products
mouthwash4 products
blush4 products
BB cream4 products
CC cream4 products
toners/astringents4 products
anti-aging4 products
body powder3 products
vapor rubs3 products
styling mousse/foam3 products
sunless tanning3 products
facial powder3 products
shaving cream3 products
shaving cream (men's)3 products
makeup primer3 products
concealer2 products
setting powder/spray2 products
detangler2 products
foot moisturizer2 products
beard care2 products
lip plumper2 products
beard oil2 products
tanning oil1 products
hair-loss treatment1 products
toothpaste1 products
mascara1 products
lip liner1 products
nail treatment1 products
hair relaxer1 products
after shave1 products
cuticle treatment1 products
bubble bath1 products

Allergies/immunotoxicity

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Concern Reference
Known human immune system toxicant or allergenSCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999.
Limited evidence of [[system]] toxicity or allergiesEuropean Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Eugenol; 2-methoxy-4-(prop-2-en-1-yl)phenol; -; - 2-methoxy-4-prop-2-enylphenol; -2-methoxy-4-prop-2-enylphenol; 1 -allyl-3-methoxy-4-hydroxyben- zene; 2-METHOXY-4-(2-PROPENYL)PHENOL; 2-methoxy-4-(prop-2-en-1-yl)phenol; 2-METHOXY-4-PROP-2-ENYLPHENOL; ; cas_numbers: 97-53-0
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap

Use restrictions

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Concern Reference
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn)IFRA 1/2020
Restricted in cosmetics - labeling requirement for allergensCosIng

Organ system toxicity (non-reproductive)

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Concern Reference
Deemed a moderate human health priority and was flagged by CEPA for further attention.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Deemed a moderate human health priority and was flagged by CEPA for further attention.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0
Deemed a moderate human health priority and was flagged by CEPA for further attention.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food
Designated as safe for general or specific, limited use in foodFDA Food Additive Status

Ecotoxicology

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Concern Reference
Deemed a moderate human health priority and was flagged by CEPA for further attention.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0

Data gaps

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Concern Reference
4337 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Cancer

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Concern Reference
Not likely to be carcinogenic in humansWorld Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 36, Suppl. 7 ;1987
IARC Group 3 (no cancer link)IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-597; Chemical_Name: Eugenol; ; CAS: 97-53-0

Data Sources

  • SCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999.
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Eugenol; 2-methoxy-4-(prop-2-en-1-yl)phenol; -; - 2-methoxy-4-prop-2-enylphenol; -2-methoxy-4-prop-2-enylphenol; 1 -allyl-3-methoxy-4-hydroxyben- zene; 2-METHOXY-4-(2-PROPENYL)PHENOL; 2-methoxy-4-(prop-2-en-1-yl)phenol; 2-METHOXY-4-PROP-2-ENYLPHENOL; ; cas_numbers: 97-53-0
  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • IFRA 1/2020
  • European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
  • Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 36, Suppl. 7 ;1987
  • IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-597; Chemical_Name: Eugenol; ; CAS: 97-53-0

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products that are inhalable (e.g., sprays, powders) because of respiratory concerns.
  • Products with the EWG VERIFIED mark have met use restrictions and warnings based on EWG review of company data.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

ABOUT EWG VERIFIED™

Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer