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EUGENOL
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Non-reproductive organ system toxicity (moderate)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| fragrance for women | 61 products |
| fragrance for men | 25 products |
| lipstick | 25 products |
| facial moisturizer/treatment | 18 products |
| moisturizer | 18 products |
| serums & essences | 17 products |
| body wash/cleanser | 12 products |
| lip balm | 11 products |
| moisturizer with SPF | 11 products |
| bath oil/salts/soak | 10 products |
| shampoo | 10 products |
| hair treatment/serum | 9 products |
| hair color and bleaching | 8 products |
| body oil | 8 products |
| hair styling aide | 7 products |
| hair spray | 7 products |
| body spray | 6 products |
| body firming lotion | 6 products |
| mouthwash | 6 products |
| facial cleanser | 6 products |
| styling gel/lotion | 6 products |
| conditioner | 5 products |
| antiperspirant/deodorant | 5 products |
| mask | 5 products |
| exfoliant/scrub | 4 products |
| bronzer/highlighter | 4 products |
| vapor rubs | 4 products |
| hand cream | 4 products |
| blush | 4 products |
| other men's products | 3 products |
| around-eye cream | 2 products |
| toners/astringents | 2 products |
| lip gloss | 2 products |
| antiperspirant/deodorant (men's) | 2 products |
| shaving cream | 2 products |
| BB cream | 2 products |
| beard oil | 2 products |
| bar soap | 2 products |
| lip balm with SPF | 2 products |
| sunless tanning | 1 products |
| beach & sport sunscreen | 1 products |
| facial powder | 1 products |
| liquid hand soap | 1 products |
| shaving cream (men's) | 1 products |
| detangler | 1 products |
| foot moisturizer | 1 products |
| oil controller | 1 products |
| anti-aging | 1 products |
| nail treatment | 1 products |
| styling mousse/foam | 1 products |
| makeup with SPF | 1 products |
| lip plumper | 1 products |
| cuticle treatment | 1 products |
| baby oil | 1 products |
| mascara | 1 products |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| Known human immune system toxicant or allergen | SCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999. |
| Limited evidence of immune system toxicity or allergies | National Library of Medicine HazMap |
| Limited evidence of [[system]] toxicity or allergies | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Eugenol; 2-methoxy-4-(prop-2-en-1-yl)phenol; -; - 2-methoxy-4-prop-2-enylphenol; -2-methoxy-4-prop-2-enylphenol; 1 -allyl-3-methoxy-4-hydroxyben- zene; 2-METHOXY-4-(2-PROPENYL)PHENOL; 2-methoxy-4-(prop-2-en-1-yl)phenol; 2-METHOXY-4-PROP-2-ENYLPHENOL; ; cas_numbers: 97-53-0 |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as expected to be toxic or harmful | Environment Canada Domestic Substance List |
| Deemed a moderate human health priority and was flagged by CEPA for further attention. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0 |
Cancer
| Concern | Reference |
|---|---|
| IARC Group 3 (no cancer link) | IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-597; Chemical_Name: Eugenol; ; CAS: 97-53-0 |
| Not likely to be carcinogenic in humans | World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 36, Suppl. 7 ;1987 |
Data gaps
| Concern | Reference |
|---|---|
| 4337 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
| Concern | Reference |
|---|---|
| Deemed a moderate human health priority and was flagged by CEPA for further attention. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0 |
Multiple, additive exposure sources
| Concern | Reference |
|---|---|
| Designated as safe for general or specific, limited use in food | FDA Food Additive Status |
| Designated as safe for general or specific, limited use in food | FDA Everything Added to Food |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Deemed a moderate human health priority and was flagged by CEPA for further attention. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0 |
| Deemed a moderate human health priority and was flagged by CEPA for further attention. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0 |
Use restrictions
| Concern | Reference |
|---|---|
| Restricted in cosmetics - labeling requirement for allergens | CosIng |
Data Sources
- SCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999.
- NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
- European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Eugenol; 2-methoxy-4-(prop-2-en-1-yl)phenol; -; - 2-methoxy-4-prop-2-enylphenol; -2-methoxy-4-prop-2-enylphenol; 1 -allyl-3-methoxy-4-hydroxyben- zene; 2-METHOXY-4-(2-PROPENYL)PHENOL; 2-methoxy-4-(prop-2-en-1-yl)phenol; 2-METHOXY-4-PROP-2-ENYLPHENOL; ; cas_numbers: 97-53-0
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0
- IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-597; Chemical_Name: Eugenol; ; CAS: 97-53-0
- World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 36, Suppl. 7 ;1987
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
- FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
- European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
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