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EUGENOL

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (moderate) and Non-reproductive organ system toxicity (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is HIGH

Products with this Ingredient

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fragrance for women72 products
fragrance for men36 products
lipstick35 products
facial moisturizer/treatment20 products
serums & essences19 products
moisturizer18 products
lip gloss16 products
shampoo12 products
lip balm12 products
body wash/cleanser11 products
hair spray10 products
bath oil/salts/soak10 products
hair treatment/serum9 products
hair color and bleaching8 products
body firming lotion7 products
hair styling aide7 products
conditioner6 products
styling gel/lotion6 products
facial cleanser6 products
mask6 products
body spray6 products
hand cream6 products
antiperspirant/deodorant5 products
moisturizer with SPF5 products
bronzer/highlighter4 products
mouthwash4 products
body oil4 products
blush4 products
shaving cream3 products
vapor rubs3 products
other men's products3 products
toners/astringents3 products
exfoliant/scrub3 products
bar soap3 products
antiperspirant/deodorant (men's)2 products
around-eye cream2 products
anti-aging1 products
detangler1 products
after shave1 products
facial powder1 products
cuticle treatment1 products
liquid hand soap1 products
lip plumper1 products
styling mousse/foam1 products
sunless tanning1 products
foot moisturizer1 products
nail treatment1 products
oil controller1 products
beard oil1 products
mascara1 products

Allergies/immunotoxicity

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Concern Reference
Known human immune system toxicant or allergenSCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999.
Limited evidence of immune system toxicity or allergiesNational Library of Medicine HazMap
Limited evidence of [[system]] toxicity or allergiesEuropean Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Eugenol; 2-methoxy-4-(prop-2-en-1-yl)phenol; -; - 2-methoxy-4-prop-2-enylphenol; -2-methoxy-4-prop-2-enylphenol; 1 -allyl-3-methoxy-4-hydroxyben- zene; 2-METHOXY-4-(2-PROPENYL)PHENOL; 2-methoxy-4-(prop-2-en-1-yl)phenol; 2-METHOXY-4-PROP-2-ENYLPHENOL; ; cas_numbers: 97-53-0

Use restrictions

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Concern Reference
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn)IFRA 1/2020
Restricted in cosmetics - labeling requirement for allergensCosIng

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Deemed a moderate human health priority and was flagged by CEPA for further attention.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0

Cancer

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Concern Reference
IARC Group 3 (no cancer link)IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-597; Chemical_Name: Eugenol; ; CAS: 97-53-0
Not likely to be carcinogenic in humansWorld Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 36, Suppl. 7 ;1987

Data gaps

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Concern Reference
4337 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Deemed a moderate human health priority and was flagged by CEPA for further attention.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Persistence and bioaccumulation

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Concern Reference
Deemed a moderate human health priority and was flagged by CEPA for further attention.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0
Deemed a moderate human health priority and was flagged by CEPA for further attention.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0

Data Sources

  • SCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999.
  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Eugenol; 2-methoxy-4-(prop-2-en-1-yl)phenol; -; - 2-methoxy-4-prop-2-enylphenol; -2-methoxy-4-prop-2-enylphenol; 1 -allyl-3-methoxy-4-hydroxyben- zene; 2-METHOXY-4-(2-PROPENYL)PHENOL; 2-methoxy-4-(prop-2-en-1-yl)phenol; 2-METHOXY-4-PROP-2-ENYLPHENOL; ; cas_numbers: 97-53-0
  • IFRA 1/2020
  • European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0
  • IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-597; Chemical_Name: Eugenol; ; CAS: 97-53-0
  • World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 36, Suppl. 7 ;1987
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products that are inhalable (e.g., sprays, powders) because of respiratory concerns.
  • Products with the EWG VERIFIED mark have met use restrictions and warnings based on EWG review of company data.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

ABOUT EWG VERIFIED™

Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer