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EUGENOL
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (moderate) and Non-reproductive organ system toxicity (moderate)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| fragrance for women | 72 products |
| fragrance for men | 36 products |
| lipstick | 35 products |
| facial moisturizer/treatment | 20 products |
| serums & essences | 19 products |
| moisturizer | 18 products |
| lip gloss | 16 products |
| shampoo | 12 products |
| lip balm | 12 products |
| body wash/cleanser | 11 products |
| hair spray | 10 products |
| bath oil/salts/soak | 10 products |
| hair treatment/serum | 9 products |
| hair color and bleaching | 8 products |
| body firming lotion | 7 products |
| hair styling aide | 7 products |
| conditioner | 6 products |
| styling gel/lotion | 6 products |
| facial cleanser | 6 products |
| mask | 6 products |
| body spray | 6 products |
| hand cream | 6 products |
| antiperspirant/deodorant | 5 products |
| moisturizer with SPF | 5 products |
| bronzer/highlighter | 4 products |
| mouthwash | 4 products |
| body oil | 4 products |
| blush | 4 products |
| shaving cream | 3 products |
| vapor rubs | 3 products |
| other men's products | 3 products |
| toners/astringents | 3 products |
| exfoliant/scrub | 3 products |
| bar soap | 3 products |
| antiperspirant/deodorant (men's) | 2 products |
| around-eye cream | 2 products |
| anti-aging | 1 products |
| detangler | 1 products |
| after shave | 1 products |
| facial powder | 1 products |
| cuticle treatment | 1 products |
| liquid hand soap | 1 products |
| lip plumper | 1 products |
| styling mousse/foam | 1 products |
| sunless tanning | 1 products |
| foot moisturizer | 1 products |
| nail treatment | 1 products |
| oil controller | 1 products |
| beard oil | 1 products |
| mascara | 1 products |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| Known human immune system toxicant or allergen | SCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999. |
| Limited evidence of immune system toxicity or allergies | National Library of Medicine HazMap |
| Limited evidence of [[system]] toxicity or allergies | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Eugenol; 2-methoxy-4-(prop-2-en-1-yl)phenol; -; - 2-methoxy-4-prop-2-enylphenol; -2-methoxy-4-prop-2-enylphenol; 1 -allyl-3-methoxy-4-hydroxyben- zene; 2-METHOXY-4-(2-PROPENYL)PHENOL; 2-methoxy-4-(prop-2-en-1-yl)phenol; 2-METHOXY-4-PROP-2-ENYLPHENOL; ; cas_numbers: 97-53-0 |
Use restrictions
| Concern | Reference |
|---|---|
| Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn) | IFRA 1/2020 |
| Restricted in cosmetics - labeling requirement for allergens | CosIng |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as expected to be toxic or harmful | Environment Canada Domestic Substance List |
| Deemed a moderate human health priority and was flagged by CEPA for further attention. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0 |
Cancer
| Concern | Reference |
|---|---|
| IARC Group 3 (no cancer link) | IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-597; Chemical_Name: Eugenol; ; CAS: 97-53-0 |
| Not likely to be carcinogenic in humans | World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 36, Suppl. 7 ;1987 |
Data gaps
| Concern | Reference |
|---|---|
| 4337 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
| Concern | Reference |
|---|---|
| Deemed a moderate human health priority and was flagged by CEPA for further attention. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0 |
Multiple, additive exposure sources
| Concern | Reference |
|---|---|
| Designated as safe for general or specific, limited use in food | FDA Food Additive Status |
| Designated as safe for general or specific, limited use in food | FDA Everything Added to Food |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Deemed a moderate human health priority and was flagged by CEPA for further attention. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0 |
| Deemed a moderate human health priority and was flagged by CEPA for further attention. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0 |
Data Sources
- SCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999.
- NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
- European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Eugenol; 2-methoxy-4-(prop-2-en-1-yl)phenol; -; - 2-methoxy-4-prop-2-enylphenol; -2-methoxy-4-prop-2-enylphenol; 1 -allyl-3-methoxy-4-hydroxyben- zene; 2-METHOXY-4-(2-PROPENYL)PHENOL; 2-methoxy-4-(prop-2-en-1-yl)phenol; 2-METHOXY-4-PROP-2-ENYLPHENOL; ; cas_numbers: 97-53-0
- IFRA 1/2020
- European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-00994; Chemical_Name: Phenol, 2-methoxy-4-(2-propenyl)-; ; CAS: 97-53-0
- IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-597; Chemical_Name: Eugenol; ; CAS: 97-53-0
- World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 36, Suppl. 7 ;1987
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
- FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
- This ingredient’s score is higher if used in products that are inhalable (e.g., sprays, powders) because of respiratory concerns.
- Products with the EWG VERIFIED mark have met use restrictions and warnings based on EWG review of company data.
ABOUT THE SKIN DEEP® RATINGS
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
ABOUT EWG VERIFIED™
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer
