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ETHYLPARABEN
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (low) and Endocrine disruption (moderate)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| foundation | 93 products |
| moisturizer | 24 products |
| concealer | 20 products |
| moisturizer with SPF | 19 products |
| eye liner | 15 products |
| eye shadow | 13 products |
| bronzer/highlighter | 11 products |
| blush | 9 products |
| facial moisturizer/treatment | 8 products |
| mascara | 8 products |
| around-eye cream | 7 products |
| serums & essences | 6 products |
| beach & sport sunscreen | 4 products |
| sunless tanning | 4 products |
| hair styling aide | 4 products |
| anti-aging | 3 products |
| mask | 3 products |
| styling gel/lotion | 3 products |
| facial powder | 3 products |
| makeup primer | 3 products |
| facial cleanser | 3 products |
| lip balm | 3 products |
| body firming lotion | 3 products |
| lip liner | 3 products |
| shampoo | 2 products |
| shaving cream | 2 products |
| conditioner | 1 products |
| brow liner | 1 products |
| detangler | 1 products |
| hand sanitizer | 1 products |
| pore strips | 1 products |
| makeup remover | 1 products |
| hair relaxer | 1 products |
Endocrine disruption
| Concern | Reference |
|---|---|
| Human endocrine disruptor - strong evidence | European Commission on Endocrine Disruption |
| One or more studies show significant wildlife and the environment disruption | European Commission on Endocrine Disruption |
| A review article reports parabens cause endocrine disruption in animals. | Boberg J, Taxvig C, Christiansen S, Hass U Possible endocrine disrupting effects of parabens and their metabolites. Reprod Toxicol. 2010 Sep;30(2):301-12. Epub 2010 Apr 8. |
| One or more studies show weak endocrine disruption | Byford JR, Shaw LE, Drew MG, Pope GS, Sauer MJ, Darbre PD Oestrogenic activity of parabens in MCF7 human breast cancer cells. J Steroid Biochem Mol Biol. 2002 Jan;80(1):49-60. |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| A review article reports parabens cause skin allergies. | Harvell, J, M. Bason and H. Maibach. Contact Urticaria and its Mechanisms. Food Chemistry and Toxicology 32(2): 103-112. 1994. (Table 2: Substances identified as capable of causing contact urticaria). |
| Parabens listed as one of the agents capable of causing contact urticaria by immunological pathogenetic mechanism. | Harvell, J, M. Bason and H. Maibach. Contact Urticaria and its Mechanisms. Food Chemistry and Toxicology 32(2): 103-112. 1994. (Table 2: Substances identified as capable of causing contact urticaria). |
Use restrictions
| Concern | Reference |
|---|---|
| Determined safe for use in cosmetics, subject to concentration or use limitations - any | Cosmetic Ingredient Review Assessments |
| Safe except for diaper ointments used on very young children. | Scientific Committee on Consumer Safety SCCS) 2011. Clarification on Opinion SCCS/1348/10 in the light of the Danish clause of safeguard banning the use of parabens in cosmetic products intended for children under three years of age. October 2011. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_069.pdf |
Data gaps
| Concern | Reference |
|---|---|
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | Cosmetic Ingredient Review Assessments |
| 193 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
| Concern | Reference |
|---|---|
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Informational
| Concern | Reference |
|---|---|
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any | Cosmetic Ingredient Review Assessments |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Not suspected to be persistent | Environment Canada Domestic Substance List |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
- EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
- Boberg J, Taxvig C, Christiansen S, Hass U Possible endocrine disrupting effects of parabens and their metabolites. Reprod Toxicol. 2010 Sep;30(2):301-12. Epub 2010 Apr 8.
- Byford JR, Shaw LE, Drew MG, Pope GS, Sauer MJ, Darbre PD Oestrogenic activity of parabens in MCF7 human breast cancer cells. J Steroid Biochem Mol Biol. 2002 Jan;80(1):49-60.
- Harvell, J, M. Bason and H. Maibach. Contact Urticaria and its Mechanisms. Food Chemistry and Toxicology 32(2): 103-112. 1994. (Table 2: Substances identified as capable of causing contact urticaria).
- Harvell, J, M. Bason and H. Maibach. Contact Urticaria and its Mechanisms. Food Chemistry and Toxicology 32(2): 103-112. 1994. (Table 2: Substances identified as capable of causing contact urticaria).
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- Scientific Committee on Consumer Safety SCCS) 2011. Clarification on Opinion SCCS/1348/10 in the light of the Danish clause of safeguard banning the use of parabens in cosmetic products intended for children under three years of age. October 2011. http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_069.pdf
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
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