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DIPROPYLENE GLYCOL

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Endocrine disruption (low), Non-reproductive organ system toxicity (low), and Irritation (skin, eyes, or lungs) (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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foundation161 products
mask91 products
serums & essences54 products
conditioner51 products
facial moisturizer/treatment38 products
antiperspirant/deodorant23 products
moisturizer with SPF22 products
body wash/cleanser21 products
facial cleanser14 products
bath oil/salts/soak13 products
shampoo12 products
toners/astringents12 products
makeup primer10 products
antiperspirant/deodorant (men's)10 products
makeup remover10 products
fragrance for women9 products
moisturizer9 products
concealer9 products
beach & sport sunscreen9 products
fragrance for men8 products
hair treatment/serum7 products
sunless tanning7 products
around-eye cream6 products
eye shadow6 products
bar soap5 products
liquid hand soap4 products
hair spray4 products
eye makeup remover4 products
bronzer/highlighter4 products
exfoliant/scrub3 products
body firming lotion3 products
detangler3 products
hair color and bleaching3 products
facial powder3 products
hair styling aide2 products
other eye makeup2 products
body spray2 products
hand cream2 products
styling gel/lotion2 products
bubble bath2 products
lip gloss1 products
eye liner1 products
lip plumper1 products
oil controller1 products
foot moisturizer1 products
shaving cream (men's)1 products
BB cream1 products
hand sanitizer1 products
baby lotion1 products
tanning oil1 products
beard care1 products

Irritation (skin, eyes, or lungs)

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Concern Reference
Human any irritant - strong evidenceCosmetic Ingredient Review Assessments
Mild skin irritant in animal tests.Cosmetic Ingredient Review (CIR) 2015. CIR Assessments. Appears as: listid: CIR-0335; Chemical_Name: Dipropylene glycol ; ; ; Classification: QQQ01,QQQ11; X;

Developmental/reproductive toxicity

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Concern Reference
Limited evidence of [[system]] toxicityUS. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0688; Chemical_Name: Glycol ethers; Synonyms: Cellosolve solvents;

Organ system toxicity (non-reproductive)

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Concern Reference
Decreased hemoglobin or number of red blood cellsUS. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0688; Chemical_Name: Glycol ethers; Synonyms: Cellosolve solvents;
Effects on kidneys observed at high doses in chronic toxicity study in rats.2004 NTP toxicology and carcinogensis studies of dipropylene glycol (CAS No. 25265-71-8) in F344/N rats and B6C3F1 mice (drinking water studies). National Toxicology Program technical report series(511), 6-260.
Renal failure occurred in an adult man who ingested dipropylene glycol .Frank LoVecchio, Cameron Nourani, D J. Watts, K. L. Wallance & P. M. Wax. 2008. Acute renal failure, neuropathy, and myopathy after ingestion of dipropylene glycol fog solution. The American journal of emergency medicine 26(5), 635.e1-2.
[[system]] - weight of evidence unknown/unassessed/unreview: published lit review or major tox studyUS. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0688; Chemical_Name: Glycol ethers; Synonyms: Cellosolve solvents;
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List
Classified as a low human health priorityEnvironment Canada Domestic Substance List

Endocrine disruption

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Concern Reference
Cellular assays show evidence of endocrine disrupting activity.National Toxicology Program (NTP) 2015. EWG Toxcast Analysis. Appears as: CAS: 25265-71-8; Chemical_Name: Dipropylene glycol

Allergies/immunotoxicity

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Concern Reference
Contact dermatitis was rarely observed in a human patch test study with 500 participants.J D. Johansen, G. B. Jemec & S. C. Rastogi. 1995. Contact sensitization to dipropylene glycol in an eczema population. Contact dermatitis 33(3), 211-2.

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
73 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • Cosmetic Ingredient Review (CIR) 2015. CIR Assessments. Appears as: listid: CIR-0335; Chemical_Name: Dipropylene glycol ; ; ; Classification: QQQ01,QQQ11; X;
  • US. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0688; Chemical_Name: Glycol ethers; Synonyms: Cellosolve solvents;
  • 2004 NTP toxicology and carcinogensis studies of dipropylene glycol (CAS No. 25265-71-8) in F344/N rats and B6C3F1 mice (drinking water studies). National Toxicology Program technical report series(511), 6-260.
  • Frank LoVecchio, Cameron Nourani, D J. Watts, K. L. Wallance & P. M. Wax. 2008. Acute renal failure, neuropathy, and myopathy after ingestion of dipropylene glycol fog solution. The American journal of emergency medicine 26(5), 635.e1-2.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • National Toxicology Program (NTP) 2015. EWG Toxcast Analysis. Appears as: CAS: 25265-71-8; Chemical_Name: Dipropylene glycol
  • J D. Johansen, G. B. Jemec & S. C. Rastogi. 1995. Contact sensitization to dipropylene glycol in an eczema population. Contact dermatitis 33(3), 211-2.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products that are inhalable (e.g., sprays, powders) because of respiratory concerns.
  • This ingredient’s score is higher if used in products intended for use around the eyes due to increased risk of absorption.

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