Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
|serums & essences||73 products|
|facial moisturizer/treatment||59 products|
|antiperspirant/deodorant (men's)||42 products|
|body wash/cleanser||35 products|
|daily use with SPF||33 products|
|facial cleanser||26 products|
|hair treatment/serum||22 products|
|bar soap||17 products|
|body firming lotion||17 products|
|makeup primer||17 products|
|bath oil/salts/soak||17 products|
|sunless tanning||15 products|
|CC cream||14 products|
|brow liner||12 products|
|fragrance for women||11 products|
|around-eye cream||10 products|
|recreational sunscreen||10 products|
|fragrance for men||9 products|
|setting powder/spray||9 products|
|BB cream||8 products|
|hand cream||8 products|
|makeup remover||8 products|
|liquid hand soap||6 products|
|hair styling aide||6 products|
|eye shadow||6 products|
|eye makeup remover||5 products|
|hair spray||4 products|
|hair color and bleaching||4 products|
|body spray||4 products|
|styling mousse/foam||3 products|
|facial powder||3 products|
|other eye makeup||2 products|
|eye liner||2 products|
|bubble bath||2 products|
|tanning oil||1 products|
|baby lotion||1 products|
|beard care||1 products|
|hand sanitizer||1 products|
|foot moisturizer||1 products|
|shaving cream (men's)||1 products|
|lip gloss||1 products|
|oil controller||1 products|
|lip plumper||1 products|
|styling gel/lotion||1 products|
Irritation (skin, eyes, or lungs)
|Human any irritant - strong evidence||Cosmetic Ingredient Review Assessments|
|Mild skin irritant in animal tests.||Cosmetic Ingredient Review (CIR) 2015. CIR Assessments. Appears as: listid: CIR-0335; Chemical_Name: Dipropylene glycol ; ; ; Classification: QQQ01,QQQ11; X;|
|Limited evidence of [[system]] toxicity||US. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0688; Chemical_Name: Glycol ethers; Synonyms: Cellosolve solvents;|
Organ system toxicity (non-reproductive)
|Decreased hemoglobin or number of red blood cells||US. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0688; Chemical_Name: Glycol ethers; Synonyms: Cellosolve solvents;|
|Effects on kidneys observed at high doses in chronic toxicity study in rats.||2004 NTP toxicology and carcinogensis studies of dipropylene glycol (CAS No. 25265-71-8) in F344/N rats and B6C3F1 mice (drinking water studies). National Toxicology Program technical report series(511), 6-260.|
|Renal failure occurred in an adult man who ingested dipropylene glycol .||Frank LoVecchio, Cameron Nourani, D J. Watts, K. L. Wallance & P. M. Wax. 2008. Acute renal failure, neuropathy, and myopathy after ingestion of dipropylene glycol fog solution. The American journal of emergency medicine 26(5), 635.e1-2.|
|Classified as a low human health priority||Environment Canada Domestic Substance List|
|Classified as not expected to be potentially toxic or harmful||Environment Canada Domestic Substance List|
|[[system]] - weight of evidence unknown/unassessed/unreview: published lit review or major tox study||US. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0688; Chemical_Name: Glycol ethers; Synonyms: Cellosolve solvents;|
|Cellular assays show evidence of endocrine disrupting activity.||National Toxicology Program (NTP) 2015. EWG Toxcast Analysis. Appears as: CAS: 25265-71-8; Chemical_Name: Dipropylene glycol|
|Contact dermatitis was rarely observed in a human patch test study with 500 participants.||J D. Johansen, G. B. Jemec & S. C. Rastogi. 1995. Contact sensitization to dipropylene glycol in an eczema population. Contact dermatitis 33(3), 211-2.|
|Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product||Cosmetic Ingredient Review Assessments|
|73 studies in PubMed science library may include information on the toxicity of this chemical||NLM PubMed|
Persistence and bioaccumulation
|Not suspected to be bioaccumulative||Environment Canada Domestic Substance List|
|Not suspected to be persistent||Environment Canada Domestic Substance List|
|Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any||Cosmetic Ingredient Review Assessments|
|Not suspected to be an environmental toxin||Environment Canada Domestic Substance List|
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- Cosmetic Ingredient Review (CIR) 2015. CIR Assessments. Appears as: listid: CIR-0335; Chemical_Name: Dipropylene glycol ; ; ; Classification: QQQ01,QQQ11; X;
- 2004 NTP toxicology and carcinogensis studies of dipropylene glycol (CAS No. 25265-71-8) in F344/N rats and B6C3F1 mice (drinking water studies). National Toxicology Program technical report series(511), 6-260.
- Frank LoVecchio, Cameron Nourani, D J. Watts, K. L. Wallance & P. M. Wax. 2008. Acute renal failure, neuropathy, and myopathy after ingestion of dipropylene glycol fog solution. The American journal of emergency medicine 26(5), 635.e1-2.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- National Toxicology Program (NTP) 2015. EWG Toxcast Analysis. Appears as: CAS: 25265-71-8; Chemical_Name: Dipropylene glycol
- J D. Johansen, G. B. Jemec & S. C. Rastogi. 1995. Contact sensitization to dipropylene glycol in an eczema population. Contact dermatitis 33(3), 211-2.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- This ingredient’s score is higher if used in products that are inhalable (e.g., sprays, powders) because of respiratory concerns.
- This ingredient’s score is higher if used in products intended for use around the eyes due to increased risk of absorption.
ABOUT THE SKIN DEEP® RATINGS
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
ABOUT EWG VERIFIED™
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer