D&C Yellow No. 11 (CI 47000)
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (high), Endocrine disruption (low), and Non-reproductive organ system toxicity (low)
Cancer 

Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity 

Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity 

Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
nail polish | 62 products |
hair treatment/serum | 20 products |
polish remover | 15 products |
conditioner | 3 products |
body oil | 1 products |
beach & sport sunscreen | 1 products |
mask | 1 products |
styling gel/lotion | 1 products |
nail treatment | 1 products |
hair styling aide | 1 products |
serums & essences | 1 products |
eye shadow | 1 products |
Use restrictions
Concern | Reference |
---|---|
Violation of government restrictions - Banned or found unsafe for use in cosmetics | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive approved by FDA for use in cosmetics: external use only | FDA Color Additive Status |
Cancer
Concern | Reference |
---|---|
The National Toxicology Program concluded there is some evidence that this substance is carcinogenic based on animal testing. | William Eastin 1991. NTP technical report on the toxicity studies of D&C Yellow No. 11 in F344/N Rats and B6C3F1 Mice (Feed Studies) (CAS No. 8003-22-3). Toxicity report series 8, 1-32. |
A peer-reviewed study reports evidence that this substance may interfere with DNA repair. | Farah Md Chequer, Vinicius P Venancio, Mara R. Almeida, Alexandre F. Aissa, Maria Lourdes P. Bianchi & Lusânia Mg Antunes. 2017. Erythrosine B and quinoline yellow dyes regulate DNA repair gene expression in human HepG2 cells. Toxicology and industrial health 33(10), 765-774. |
Allergies/immunotoxicity
Concern | Reference |
---|---|
Allergic contact dermatitis reported in humans following occupational exposure. | K Matsunaga, K. Hosokawa, M. Suzuki, Y. Arima & R. Hayakawa. 1988. Occupational allergic contact dermatitis in beauticians. Contact dermatitis 18(2), 94-6. |
May cause an allergic skin reaction. | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: 1,3-isobenzofurandione, reaction products with methylquinoline and quinoline; 2-(quinolin-2-yl)-2,3-dihydro-1H-indene-1,3-dione; -; 1,3-Isobenzofurandione, reaction products with methylquinoline and quinoline; 2-(quinolin-2-yl)-2,3-dihydro-1H-indene-1; cas_numbers: 8003-22-3 |
A peer-reviewed study reports evidence of dermal sensitization from animal testing. | M J. Palazzolo & L. C. DiPasquale. 1983. The sensitization potential of D & C Yellow No. 11 in guinea pigs. Contact dermatitis 9(5), 367-71. |
Developmental/reproductive toxicity
Concern | Reference |
---|---|
The National Toxicology Program reports evidence this substance may have developmental effects. | William Eastin 1991. NTP technical report on the toxicity studies of D&C Yellow No. 11 in F344/N Rats and B6C3F1 Mice (Feed Studies) (CAS No. 8003-22-3). Toxicity report series 8, 1-32. |
Endocrine disruption
Concern | Reference |
---|---|
A peer-reviewed study reports endocrine activity in cellular assays. | Patrick Tarnow, Catrin Zordick, Alex Bottke, Berit Fischer, Friederike Kühne, Tewes Tralau & Andreas Luch 2020. Characterization of Quinoline Yellow Dyes As Transient Aryl Hydrocarbon Receptor Agonists. Chemical research in toxicology 33(3), 742-750. |
Organ system toxicity (non-reproductive)
Concern | Reference |
---|---|
A peer-reviewed study reports of evidence of kidney and liver effects at high doses in animal testing. | W C. Eastin, M. R. Elwell, S. Grumbein & J. H. Yuan. 1996. Effects of D&C yellow no. 11 ingestion on F344/N rats and B6C3F1 mice. Journal of toxicology and environmental health 48(2), 197-213. |
This chemical was NOT flagged by CEPA for further attention. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-06950; Chemical_Name: C.I. Solvent yellow 33; ; CAS: 8003-22-3 |
Miscellaneous
Concern | Reference |
---|---|
Allergic contact dermatitis reported in humans following occupational exposure. | K Matsunaga, K. Hosokawa, M. Suzuki, Y. Arima & R. Hayakawa. 1988. Occupational allergic contact dermatitis in beauticians. Contact dermatitis 18(2), 94-6. |
Data gaps
Concern | Reference |
---|---|
38 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
Concern | Reference |
---|---|
This chemical was NOT flagged by CEPA for further attention. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-06950; Chemical_Name: C.I. Solvent yellow 33; ; CAS: 8003-22-3 |
Informational
Concern | Reference |
---|---|
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmetics: external use only | FDA Color Additive Status |
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug Administration | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Persistence and bioaccumulation
Concern | Reference |
---|---|
This chemical was NOT flagged by CEPA for further attention. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-06950; Chemical_Name: C.I. Solvent yellow 33; ; CAS: 8003-22-3 |
This chemical was NOT flagged by CEPA for further attention. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-06950; Chemical_Name: C.I. Solvent yellow 33; ; CAS: 8003-22-3 |
Data Sources
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
- FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
- William Eastin 1991. NTP technical report on the toxicity studies of D&C Yellow No. 11 in F344/N Rats and B6C3F1 Mice (Feed Studies) (CAS No. 8003-22-3). Toxicity report series 8, 1-32.
- Farah Md Chequer, Vinicius P Venancio, Mara R. Almeida, Alexandre F. Aissa, Maria Lourdes P. Bianchi & Lusânia Mg Antunes. 2017. Erythrosine B and quinoline yellow dyes regulate DNA repair gene expression in human HepG2 cells. Toxicology and industrial health 33(10), 765-774.
- K Matsunaga, K. Hosokawa, M. Suzuki, Y. Arima & R. Hayakawa. 1988. Occupational allergic contact dermatitis in beauticians. Contact dermatitis 18(2), 94-6.
- European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: 1,3-isobenzofurandione, reaction products with methylquinoline and quinoline; 2-(quinolin-2-yl)-2,3-dihydro-1H-indene-1,3-dione; -; 1,3-Isobenzofurandione, reaction products with methylquinoline and quinoline; 2-(quinolin-2-yl)-2,3-dihydro-1H-indene-1; cas_numbers: 8003-22-3
- M J. Palazzolo & L. C. DiPasquale. 1983. The sensitization potential of D & C Yellow No. 11 in guinea pigs. Contact dermatitis 9(5), 367-71.
- Patrick Tarnow, Catrin Zordick, Alex Bottke, Berit Fischer, Friederike Kühne, Tewes Tralau & Andreas Luch 2020. Characterization of Quinoline Yellow Dyes As Transient Aryl Hydrocarbon Receptor Agonists. Chemical research in toxicology 33(3), 742-750.
- W C. Eastin, M. R. Elwell, S. Grumbein & J. H. Yuan. 1996. Effects of D&C yellow no. 11 ingestion on F344/N rats and B6C3F1 mice. Journal of toxicology and environmental health 48(2), 197-213.
- Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-06950; Chemical_Name: C.I. Solvent yellow 33; ; CAS: 8003-22-3
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- This ingredient’s score is higher if used in products intended for damaged skin due to increased risk of absorption.
- This ingredient’s score is higher if used in products intended for use around mouth due to increased risk of ingestion and absorption.
- This ingredient’s score is higher if used in products intended for use on lips due to increased risk of ingestion and absorption.
- This ingredient’s score is higher if used in products intended for use around the eyes due to increased risk of absorption.
- Products with the EWG VERIFIED mark have met use restrictions and warnings based on EWG review of company data.
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