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D&C Yellow No. 10 (CI 47005)

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Neurotoxicity (low), Endocrine disruption (low), Irritation (skin, eyes, or lungs) (low), and Contamination concerns (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

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liquid hand soap12 products
body wash/cleanser10 products
nail polish8 products
bath oil/salts/soak5 products
toothpaste5 products
shampoo4 products
bar soap4 products
mouthwash3 products
hair styling aide3 products
moisturizer3 products
conditioner2 products
baby shampoo2 products
facial moisturizer/treatment2 products
sunless tanning2 products
styling gel/lotion1 products
facial cleanser1 products
anti-aging1 products
after sun product1 products
body firming lotion1 products
lip plumper1 products
bubble bath1 products
hair relaxer1 products

Contamination concerns

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Use restrictions

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Concern Reference
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyesFDA Color Additive Status

Allergies/immunotoxicity

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Concern Reference
EFSA reports that Yellow 10 intolerance/sensitivity has been reported in humans.European Food Safety Authority (EFSA) 2009. Scientific Opinion on the re‐evaluation of Quinoline Yellow (E 104) as a food additive. EFSA Journal 7(11), 1329.

Neurotoxicity

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Concern Reference
EFSA concludes there is limited evidence that Yellow 10 in a mixture with other synthetic colours and sodium benzoate has a "small and statistically significant effect on activity and attention in children selected from the general population".European Food Safety Authority (EFSA) 2009. Scientific Opinion on the re‐evaluation of Quinoline Yellow (E 104) as a food additive. EFSA Journal 7(11), 1329.

Irritation (skin, eyes, or lungs)

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Concern Reference
SCCS notes there is limited evidence of skin and eye irritation.European Commission, Scientific Committee on Consumer Safety (SCCS) 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 3.

Cancer

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Concern Reference
A review article reports equivocal evidence of genotoxicity, including in human cell assays.Peer Reviewed Literature 2020. Amchova, P., H. Kotolova & J. Ruda-Kucerova. 2015. Health safety issues of synthetic food colorants. Regulatory toxicology and pharmacology : RTP 73(3), 914-22. . Appears as: Chemical_name: Quinoline Yellow;

Developmental/reproductive toxicity

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Concern Reference
SCCS reports that developmental effects have been observed in animal tests.European Commission, Scientific Committee on Consumer Safety (SCCS) 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 3.

Endocrine disruption

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Concern Reference
Evidence of endocrine activity from cellular assays.National Toxicology Program (NTP) 2015. EWG Toxcast Analysis. Appears as: CAS: 8004-92-0; Chemical_Name: C.I. Acid yellow 3 disodium salt

Data gaps

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Concern Reference
50 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmeticsFDA Color Additive Status
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List
Classified as a low human health priorityEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • European Food Safety Authority (EFSA) 2009. Scientific Opinion on the re‐evaluation of Quinoline Yellow (E 104) as a food additive. EFSA Journal 7(11), 1329.
  • European Food Safety Authority (EFSA) 2009. Scientific Opinion on the re‐evaluation of Quinoline Yellow (E 104) as a food additive. EFSA Journal 7(11), 1329.
  • European Commission, Scientific Committee on Consumer Safety (SCCS) 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 3.
  • Peer Reviewed Literature 2020. Amchova, P., H. Kotolova & J. Ruda-Kucerova. 2015. Health safety issues of synthetic food colorants. Regulatory toxicology and pharmacology : RTP 73(3), 914-22. . Appears as: Chemical_name: Quinoline Yellow;
  • National Toxicology Program (NTP) 2015. EWG Toxcast Analysis. Appears as: CAS: 8004-92-0; Chemical_Name: C.I. Acid yellow 3 disodium salt
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products intended for use around the eyes due to increased risk of absorption.
  • Products with the EWG VERIFIED mark have met the program’s impurity and use restrictions based on EWG's review of the company's data.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

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Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer