D&C Red No. 33 (CI 17200) Lake
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
|lip gloss||61 products|
|lip liner||16 products|
|eye shadow||8 products|
|lip balm||6 products|
|lip plumper||6 products|
|lip balm with SPF||4 products|
|nail polish||1 products|
|body wash/cleanser||1 products|
|hair color and bleaching||1 products|
|bar soap||1 products|
|Restricted in European cosmetics||EU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-31627; Chemical_Name: ACID RED 33; ; CAS: 3567-66-6|
|Determined safe for use in cosmetics, subject to concentration or use limitations - any||FDA Color Additive Status|
Organ system toxicity (non-reproductive)
|Limited evidence of any toxicity||Klaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull|
|Classified as not expected to be potentially toxic or harmful||Environment Canada Domestic Substance List|
|Changes in immune endpoints were observed in an animal dosing study.||European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n° C22.|
|No evidence of carcinogenicity from animal testing.||European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA nï¿½ C22.|
|Not considered genotoxic based on in vivo and in vitro testing.||European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n° C22.|
|5 studies in PubMed science library may include information on the toxicity of this chemical||NLM PubMed|
|No reproductive/developmentl toxicity reported from animal testing.||European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n° C22.|
|Not suspected to be an environmental toxin||Environment Canada Domestic Substance List|
|Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives Lakes - Batch Certified by the U.S. Food and Drug Administration||CTFA International Cosmetic Ingredient Dictionary and Handbook|
Persistence and bioaccumulation
|Not suspected to be bioaccumulative||Environment Canada Domestic Substance List|
- EU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-31627; Chemical_Name: ACID RED 33; ; CAS: 3567-66-6
- FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
- Klaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA nï¿½ C22.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
- This ingredient’s score is higher if used in products that are inhalable (e.g., sprays, powders) because of respiratory concerns.
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