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D&C Red No. 33 (CI 17200)

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high) and Contamination concerns (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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body wash/cleanser282 products
liquid hand soap218 products
lipstick172 products
shampoo148 products
bath oil/salts/soak139 products
conditioner128 products
fragrance for women56 products
bubble bath50 products
lip gloss49 products
hand sanitizer41 products
exfoliant/scrub40 products
bar soap38 products
hair styling aide30 products
mask27 products
facial cleanser25 products
fragrance for men19 products
moisturizer19 products
styling gel/lotion18 products
body spray18 products
mouthwash18 products
brow liner15 products
facial moisturizer/treatment15 products
hair treatment/serum15 products
makeup primer10 products
polish remover10 products
shaving cream9 products
blush9 products
foundation8 products
hair color and bleaching8 products
bronzer/highlighter7 products
baby bubble bath7 products
sunless tanning6 products
daily use with SPF6 products
baby lotion6 products
foot moisturizer6 products
toners/astringents5 products
body firming lotion5 products
detangler5 products
toothpaste4 products
hand cream4 products
foot cleansing4 products
serums & essences4 products
3 products
antiperspirant/deodorant3 products
hair relaxer3 products
after sun product3 products
recreational sunscreen3 products
nail polish2 products
eye liner2 products
makeup remover2 products
lip plumper2 products
tanning oil1 products
lip balm with SPF1 products
baby shampoo1 products
body art1 products
body oil1 products
anti-aging1 products
hair spray1 products
lip balm1 products
beard care1 products
BB cream1 products
nail treatment1 products
styling mousse/foam1 products
glitter1 products
around-eye cream1 products
hair-loss treatment1 products

Contamination concerns

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Use restrictions

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Concern Reference
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyesFDA Color Additive Status
Determined safe for use in cosmetics, subject to concentration or use limitations - Color additive approved by FDA for limited uses in cosmeticsFDA Color Additive Status

Allergies/immunotoxicity

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Concern Reference
Changes in immune endpoints were observed in an animal dosing study.European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n° C22.

Cancer

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Concern Reference
No evidence of carcinogenicity from animal testing.European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n� C22.
Not considered genotoxic based on in vivo and in vitro testing.European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n° C22.

Data gaps

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Concern Reference
47 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Developmental/reproductive toxicity

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Concern Reference
No reproductive/developmentl toxicity reported from animal testing.European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n° C22.

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive not approved by FDA for cosmetics used around eyesFDA Color Additive Status
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n° C22.
  • European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n� C22.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products intended for use around the eyes due to increased risk of absorption.

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