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D&C Red No. 33 (CI 17200)
Score:
Data: Limited
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (high) and Contamination concerns (high)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| body wash/cleanser | 197 products |
| lipstick | 160 products |
| liquid hand soap | 140 products |
| shampoo | 114 products |
| bath oil/salts/soak | 109 products |
| conditioner | 100 products |
| lip gloss | 37 products |
| fragrance for women | 36 products |
| bubble bath | 32 products |
| bar soap | 26 products |
| exfoliant/scrub | 25 products |
| mask | 25 products |
| moisturizer | 20 products |
| facial cleanser | 18 products |
| hair styling aide | 17 products |
| mouthwash | 15 products |
| hand sanitizer | 12 products |
| facial moisturizer/treatment | 12 products |
| fragrance for men | 12 products |
| brow liner | 11 products |
| serums & essences | 9 products |
| hair treatment/serum | 8 products |
| foundation | 8 products |
| blush | 8 products |
| sunless tanning | 7 products |
| makeup primer | 7 products |
| baby lotion | 6 products |
| body spray | 6 products |
| bronzer/highlighter | 6 products |
| daily use with SPF | 6 products |
| polish remover | 6 products |
| styling gel/lotion | 6 products |
| foot moisturizer | 5 products |
| shaving cream | 5 products |
| hair color and bleaching | 4 products |
| detangler | 4 products |
| toothpaste | 4 products |
| 4 products | |
| nail polish | 3 products |
| recreational sunscreen | 3 products |
| toners/astringents | 3 products |
| antiperspirant/deodorant | 3 products |
| baby bubble bath | 3 products |
| foot cleansing | 3 products |
| makeup remover | 2 products |
| hand cream | 2 products |
| after sun product | 2 products |
| baby shampoo | 2 products |
| body firming lotion | 2 products |
| hair relaxer | 2 products |
| lip plumper | 2 products |
| eye liner | 2 products |
| glitter | 1 products |
| body oil | 1 products |
| lip balm with SPF | 1 products |
| BB cream | 1 products |
| lip balm | 1 products |
| body art | 1 products |
| around-eye cream | 1 products |
| hair-loss treatment | 1 products |
| tanning oil | 1 products |
Contamination concerns
| Chemical |
|---|
| BIPHENYL-2-YLAMINE |
Use restrictions
| Concern | Reference |
|---|---|
| Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyes | FDA Color Additive Status |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Color additive approved by FDA for limited uses in cosmetics | FDA Color Additive Status |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| Changes in immune endpoints were observed in an animal dosing study. | European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n° C22. |
Cancer
| Concern | Reference |
|---|---|
| No evidence of carcinogenicity from animal testing. | European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n� C22. |
| Not considered genotoxic based on in vivo and in vitro testing. | European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n° C22. |
Data gaps
| Concern | Reference |
|---|---|
| 47 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Developmental/reproductive toxicity
| Concern | Reference |
|---|---|
| No reproductive/developmentl toxicity reported from animal testing. | European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n° C22. |
Ecotoxicology
| Concern | Reference |
|---|---|
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Informational
| Concern | Reference |
|---|---|
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive not approved by FDA for cosmetics used around eyes | FDA Color Additive Status |
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug Administration | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
- FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
- European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n° C22.
- European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n� C22.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
- This ingredient’s score is higher if used in products intended for use around the eyes due to increased risk of absorption.
ABOUT THE SKIN DEEP® RATINGS
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
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