EWG Skin Deep® | What is D&C Red No. 33 (CI 17200)

HOW WE DETERMINE SCORES Learn more About EWG VERIFIED™

Data: Limited

D&C Red No. 33 (Ci 17200)

This ingredient’s score is higher if used in products intended for use around the eyes due to increased risk of absorption.

IMAGE SOURCE: PubChem

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Other Concerns

Use restrictions (high) and Contamination concerns (high)

SYNONYMS

● 2,7-NAPHTHALENEDISULFONI C ACID, 5-AMINO-4-HYDROXY-3-(PHENYLAZO)-, DISODIUM SALT

● 2,7NAPHTHALENEDISULFONIC ACID, 5AMINO4HYDROXY3(PHENYLAZO), DISODIUM SALT

● 5-AMINO-4-HYDROXY-3-(PHENYLAZO)- DISODIUM SALT 2,7-NAPHTHALENEDISULFONI C ACID

● CI 17200

● D&C RED 33

● D&C RED NO. 33

● D&C RED NO. 33 (CI 17200)

● DISODIUM 5-AMINO-4-HYDROXY-3-(PHENYLAZO)NAPHTHALENE-2,7-DISULPHONATE

● DISODIUM SALT 2,7-NAPHTHALENEDISULFONI C ACID, 5-AMINO-4-HYDROXY-3-(PHENYLAZO)-

● FD&C RED 33

● RED 33

Unacceptable

Unacceptable: EWG VERIFIED products cannot contain this ingredient

D&C Red 33 is a synthetic dye produced from petroleum or coal tar sources; this dye is FDA-approved for use in pharmaceuticals and cosmetics.

Common concerns

See how this product scores for common concerns.

MODERATE

Cancer
LOW

Allergies & Immunotoxicity
LOW

Developmental and Reproductive Toxicity
HIGH

Use Restrictions

Ingredient concerns

CONCERNS
DATA SOURCES

Products with this Ingredient

body wash/cleanser	288 products
liquid hand soap	245 products
shampoo	138 products
bath oil/salts/soak	123 products
lipstick	101 products
conditioner	94 products
fragrance for women	83 products
exfoliant/scrub	46 products
lip gloss	44 products
bar soap	41 products
hand sanitizer	40 products
mask	35 products
sunless tanning	33 products
facial cleanser	31 products
body spray	30 products
lip balm	25 products
moisturizer	24 products
hair treatment/serum	22 products
hair styling aide	21 products
bubble bath	20 products
fragrance for men	18 products
eye liner	18 products
brow liner	16 products
mouthwash	15 products
facial moisturizer/treatment	15 products
blush	13 products
shaving cream	12 products
polish remover	11 products
styling gel/lotion	11 products
serums & essences	8 products
eye shadow	8 products
hand cream	7 products
hair color and bleaching	7 products
toners/astringents	5 products
body firming lotion	5 products
foot moisturizer	5 products
baby bubble bath	5 products
makeup primer	5 products
daily use with SPF	5 products
nail treatment	4 products
nail polish	3 products
bronzer/highlighter	3 products
	3 products
around-eye cream	2 products
baby lotion	2 products
hair spray	2 products
lip plumper	2 products
after sun product	2 products
setting powder/spray	2 products
antiperspirant/deodorant	1 products
baby soap	1 products
toothpaste	1 products
styling mousse/foam	1 products
antiperspirant/deodorant (men's)	1 products
eye makeup remover	1 products
shaving cream (men's)	1 products
hair relaxer	1 products
baby shampoo	1 products
recreational sunscreen	1 products
foundation	1 products

Contamination concerns

Chemical
BIPHENYL-2-YLAMINE

Use restrictions

CONCERN	REFERENCE
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyes	FDA Color Additive Status
Determined safe for use in cosmetics, subject to concentration or use limitations - Color additive approved by FDA for limited uses in cosmetics	FDA Color Additive Status

Cancer

CONCERN	REFERENCE
Limited evidence of carcinogenicity	Open scientific literature
Not likely to be mutagenic in humans	Open scientific literature
Not likely to be carcinogenic in humans	Open scientific literature

Allergies/immunotoxicity

CONCERN	REFERENCE
One or more animal studies show any or allergenic effects at moderate doses	Open scientific literature

Data gaps

CONCERN	REFERENCE
47 studies in PubMed science library may include information on the toxicity of this chemical	NLM PubMed

Ecotoxicology

CONCERN	REFERENCE
Not suspected to be an environmental toxin	Environment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

CONCERN	REFERENCE
Classified as not expected to be potentially toxic or harmful	Environment Canada Domestic Substance List

Persistence and bioaccumulation

CONCERN	REFERENCE
Not suspected to be bioaccumulative	Environment Canada Domestic Substance List

Informational

CONCERN	REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug Administration	CTFA International Cosmetic Ingredient Dictionary and Handbook
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive not approved by FDA for cosmetics used around eyes	FDA Color Additive Status

Developmental/reproductive toxicity

CONCERN	REFERENCE
Not likely to be a any toxicant in humans	Open scientific literature

FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
Open scientific/peer reviewed literature
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST

Low Availability

Moderate Availability

High Availability