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D&C Red No. 33 (CI 17200)

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high) and Contamination concerns (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lipstick153 products
body wash/cleanser96 products
liquid hand soap55 products
bath oil/salts/soak54 products
shampoo45 products
conditioner43 products
lip gloss26 products
fragrance for women24 products
mask17 products
moisturizer14 products
exfoliant/scrub14 products
bar soap13 products
bubble bath13 products
facial moisturizer/treatment8 products
facial cleanser8 products
foundation8 products
mouthwash6 products
moisturizer with SPF6 products
lip liner6 products
serums & essences6 products
body spray6 products
fragrance for men5 products
hair styling aide4 products
foot moisturizer3 products
beach & sport sunscreen3 products
polish remover3 products
hand sanitizer3 products
sunless tanning3 products
detangler2 products
baby bubble bath2 products
toners/astringents2 products
bronzer/highlighter2 products
blush2 products
makeup remover2 products
hair treatment/serum2 products
anti-aging1 products
nail polish1 products
body firming lotion1 products
antiperspirant/deodorant1 products
eye liner1 products
makeup primer1 products
hair relaxer1 products
hand cream1 products
toothpaste1 products
shaving cream1 products
foot cleansing1 products
after sun product1 products
body art1 products

Contamination concerns

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Use restrictions

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Concern Reference
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyesFDA Color Additive Status
Determined safe for use in cosmetics, subject to concentration or use limitations - Color additive approved by FDA for limited uses in cosmeticsFDA Color Additive Status

Allergies/immunotoxicity

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Concern Reference
Changes in immune endpoints were observed in an animal dosing study.European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n° C22.

Cancer

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Concern Reference
No evidence of carcinogenicity from animal testing.European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n� C22.
Not considered genotoxic based on in vivo and in vitro testing.European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n° C22.

Data gaps

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Concern Reference
47 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Developmental/reproductive toxicity

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Concern Reference
No reproductive/developmentl toxicity reported from animal testing.European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n° C22.

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive not approved by FDA for cosmetics used around eyesFDA Color Additive Status
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n° C22.
  • European Commission, Scientific Committee on Consumer Products (SCCP) 2007. Opinion on Acid Red 33C OLIPA n� C22.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products intended for use around the eyes due to increased risk of absorption.
  • Products with the EWG VERIFIED mark have met the program’s impurity and use restrictions based on EWG's review of the company's data.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

ABOUT EWG VERIFIED™

Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer