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CI 45410 (D&C Red No. 27 or 28) Lake

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Endocrine disruption (low), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lipstick2244 products
lip gloss640 products
lip balm356 products
lip liner218 products
blush152 products
lip plumper44 products
eye shadow34 products
lip balm with SPF33 products
bronzer/highlighter24 products
foundation23 products
glitter21 products
bath oil/salts/soak19 products
facial powder17 products
nail polish11 products
setting powder/spray11 products
eye liner9 products
8 products
hair color and bleaching7 products
makeup primer5 products
exfoliant/scrub3 products
concealer2 products
mask2 products
body oil1 products
makeup remover1 products
oil controller1 products
fragrance for men1 products
BB cream1 products
body powder1 products

Use restrictions

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Concern Reference
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - anyOpen scientific literature
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyesFDA Color Additive Status
Determined safe for use in cosmetics, subject to concentration or use limitations - anyFDA Color Additive Status

Persistence and bioaccumulation

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Concern Reference
Persistent, bioaccumulative in wildlifeOpen scientific literature

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as expected to be toxic or harmfulOpen scientific literature
Limited evidence of any toxicityScorecard.org Toxicity Information
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Irritation (skin, eyes, or lungs)

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Concern Reference
Limited evidence of eye irritationOpen scientific literature
One or more animal studies show any irritation at high dosesOpen scientific literature

Cancer

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Concern Reference
Cancer - weight of evidence unknown/unassessedOpen scientific literature

Developmental/reproductive toxicity

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Concern Reference
any - weight of evidence unknown/unassessedOpen scientific literature

Ecotoxicology

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Concern Reference
Suspected to be an environmental toxin and be persistent or bioaccumulativeOpen scientific literature
Wildlife and environmental toxicityOpen scientific literature
Suspected to be an environmental toxinOpen scientific literature
Suspected to be an environmental toxin and be persistent or bioaccumulative (uncertainty in environmental toxicity or persistence/bioaccumulation)Environment Canada Domestic Substance List
Uncertain environmental toxin and uncertain persistent or bioaccumulativeEnvironment Canada Domestic Substance List

Endocrine disruption

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Concern Reference
Associated with endocrine disruptionOpen scientific literature

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives Lakes - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyOpen scientific literature
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmeticsFDA Color Additive Status

Data gaps

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Concern Reference
0 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Data Sources

  • Open scientific/peer reviewed literature
  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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