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CI 45410 (D&C Red No. 27 or 28)

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Endocrine disruption (low), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lipstick598 products
lip gloss102 products
eye liner83 products
bath oil/salts/soak70 products
lip balm33 products
blush25 products
nail polish23 products
bronzer/highlighter13 products
eye shadow9 products
body wash/cleanser8 products
lip balm with SPF7 products
hair color and bleaching6 products
toothpaste4 products
moisturizer4 products
bar soap4 products
hair styling aide4 products
lip plumper4 products
body art3 products
exfoliant/scrub3 products
bubble bath3 products
glitter2 products
2 products
mask2 products
toners/astringents2 products
lip liner2 products
shampoo1 products
brow liner1 products
baby toothpaste1 products
shaving cream1 products
body firming lotion1 products

Use restrictions

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Concern Reference
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - anyOpen scientific literature
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyesFDA Color Additive Status

Persistence and bioaccumulation

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Concern Reference
Persistent, bioaccumulative in wildlifeOpen scientific literature
Persistent, bioaccumulative in wildlifeCanada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Classified as expected to be toxic or harmfulOpen scientific literature
Limited evidence of any toxicityScorecard.org Toxicity Information
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Irritation (skin, eyes, or lungs)

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Concern Reference
Limited evidence of eye irritationOpen scientific literature
One or more animal studies show any irritation at high dosesOpen scientific literature

Cancer

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Concern Reference
Cancer - weight of evidence unknown/unassessedOpen scientific literature

Developmental/reproductive toxicity

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Concern Reference
any - weight of evidence unknown/unassessedOpen scientific literature

Ecotoxicology

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Concern Reference
Suspected to be an environmental toxin and be persistent or bioaccumulativeOpen scientific literature
Suspected to be an environmental toxin and be persistent or bioaccumulativeEnvironment Canada Domestic Substance List
Wildlife and environmental toxicityOpen scientific literature
Suspected to be an environmental toxin and be persistent or bioaccumulative (uncertainty in environmental toxicity or persistence/bioaccumulation)Environment Canada Domestic Substance List
Suspected to be an environmental toxinOpen scientific literature
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List
Uncertain environmental toxin and uncertain persistent or bioaccumulativeEnvironment Canada Domestic Substance List

Endocrine disruption

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Concern Reference
Associated with endocrine disruptionOpen scientific literature

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmeticsFDA Color Additive Status
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyOpen scientific literature

Data gaps

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Concern Reference
110 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Data Sources

  • Open scientific/peer reviewed literature
  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • EC (Environment Canada). 1994. Accelerated Reduction/Elimination of Toxics (ARET). ARET substance list of persistent, bioaccumulative and toxic chemicals.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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