CI 45410 (D&C Red No. 27 or 28)
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
|lip gloss||102 products|
|eye liner||83 products|
|bath oil/salts/soak||70 products|
|lip balm||33 products|
|nail polish||23 products|
|eye shadow||9 products|
|body wash/cleanser||8 products|
|lip balm with SPF||7 products|
|hair color and bleaching||6 products|
|bar soap||4 products|
|hair styling aide||4 products|
|lip plumper||4 products|
|body art||3 products|
|bubble bath||3 products|
|lip liner||2 products|
|brow liner||1 products|
|baby toothpaste||1 products|
|shaving cream||1 products|
|body firming lotion||1 products|
|Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - any||Open scientific literature|
|Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyes||FDA Color Additive Status|
Persistence and bioaccumulation
|Persistent, bioaccumulative in wildlife||Open scientific literature|
|Persistent, bioaccumulative in wildlife||Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)|
Organ system toxicity (non-reproductive)
|Classified as expected to be toxic or harmful||Environment Canada Domestic Substance List|
|Classified as expected to be toxic or harmful||Open scientific literature|
|Limited evidence of any toxicity||Scorecard.org Toxicity Information|
|Classified as not expected to be potentially toxic or harmful||Environment Canada Domestic Substance List|
Irritation (skin, eyes, or lungs)
|Limited evidence of eye irritation||Open scientific literature|
|One or more animal studies show any irritation at high doses||Open scientific literature|
|Cancer - weight of evidence unknown/unassessed||Open scientific literature|
|any - weight of evidence unknown/unassessed||Open scientific literature|
|Suspected to be an environmental toxin and be persistent or bioaccumulative||Open scientific literature|
|Suspected to be an environmental toxin and be persistent or bioaccumulative||Environment Canada Domestic Substance List|
|Wildlife and environmental toxicity||Open scientific literature|
|Suspected to be an environmental toxin and be persistent or bioaccumulative (uncertainty in environmental toxicity or persistence/bioaccumulation)||Environment Canada Domestic Substance List|
|Suspected to be an environmental toxin||Open scientific literature|
|Suspected to be an environmental toxin||Environment Canada Domestic Substance List|
|Uncertain environmental toxin and uncertain persistent or bioaccumulative||Environment Canada Domestic Substance List|
|Associated with endocrine disruption||Open scientific literature|
|Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug Administration||CTFA International Cosmetic Ingredient Dictionary and Handbook|
|Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmetics||FDA Color Additive Status|
|Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any||Open scientific literature|
|110 studies in PubMed science library may include information on the toxicity of this chemical||NLM PubMed|
- Open scientific/peer reviewed literature
- FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
- EC (Environment Canada). 1994. Accelerated Reduction/Elimination of Toxics (ARET). ARET substance list of persistent, bioaccumulative and toxic chemicals.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
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