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Data: Fair

Ci 45410 (D&C Red No. 27 Or 28)

IMAGE SOURCE: PubChem

SEARCH PRODUCTS

Other Concerns

Use restrictions (high), Endocrine disruption (low), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (low)

SYNONYMS

● 2',4',5',7'-TETRABROMO-4,5 ,6,7-TETRACHLORO-3',6'-DIHYDROXYSPIRO[ISOBENZOFURAN-1(3H),9'-[9H]XANTHEN]-3-ONE
● 2',4',5',7'-TETRABROMO-4,5,6,7-TETRACHLORO-3',6'-DIHYDROXY-
● 2',4',5',7'-TETRABROMO-4,5,6,7-TETRACHLORO-3',6'-DIHYDROXYSPIRO[ISO BENZOFURAN-1(3H),9'-[9H]XANTHEN]-3-ONE
● 2',4',5',7'-TETRABROMO-4,5,6,7-TETRACHLORO-3',6'-DIHYDROXYSPIRO[ISOBENZOFURAN-1(3H), 9'-[9H]XANTH EN]-3-ONE
● 2',4',5',7'-TETRABROMO-4,5,6,7-TETRACHLORO-3',6'-DIHYDROXYSPIRO[ISOBENZOFURAN-1(3H),9'-[9H]XANTHEN]-3-ONE, DISODIUM SALT
● 3,4,5,6-TETRACHLORO-2-(1,4,5,8-TETRABROMO-6-HYDROXY-3-OXOXANTHEN-9-YL)BENZOIC ACID
● 9'-[9H]XANTH EN]-3-ONE 2',4',5',7'-TETRABROMO-4,5,6,7-TETRACHLORO-3',6'-DIHYDROXYSPIRO[ISOBENZOFURAN-1(3H)
● ACID RED 92, DIPOTASSIUM SALT
● ACID RED 92, POTASSIUM SALT
● AKA104(1) AKA104(1)
● AKA218
● AKA231
● BENZOIC ACID, 2,3,4,5TETRACHLORO6(2,4,5,7TETRABROMO6HYDROXY3OXO3HXANTHEN9YL)
● CI 45410 (D&C RED NO. 27 OR 28)
● CI 45410 [CAS: 84473-86-9]
● CI 45410:1
● D&C RED 27
● D&C RED 28
● D&C RED NO. 27
● D&C RED NO. 28
● DIPOTASSIUM SALT ACID RED 92
● FD&C RED 28
● PHLOXINE B K SALT
● POTASSIUM SALT ACID RED 92
● RED 27
● RED 28
● SPIRO[ISOBENZOFURAN-1(3H),9'-[9H]XANTHEN]-3-ONE, 2',4',5',7'-TETRABROMO-4,5,6,7-TETRACHLORO-3',6'-DIHYDROXY-, DISODIUM SALT

Unacceptable

Unacceptable: EWG VERIFIED products cannot contain this ingredient


D&C Red 27 is a synthetic dye produced from petroleum or coal tar sources; this dye is FDA-approved for use in pharmaceuticals and cosmetics.

Common concerns

See how this product scores for common concerns.

  • LOW
    Cancer
  • LOW
    Allergies & Immunotoxicity
  • LOW
    Developmental and Reproductive Toxicity
  • HIGH
    Use Restrictions

Ingredient concerns

  • CONCERNS
  • DATA SOURCES

Products with this Ingredient

Expand content Collapse content
lipstick477 products
lip gloss128 products
blush107 products
nail polish105 products
lip balm81 products
lip liner51 products
eye liner47 products
bath oil/salts/soak34 products
bronzer/highlighter33 products
lip balm with SPF24 products
eye shadow19 products
foundation15 products
body oil9 products
setting powder/spray8 products
hair color and bleaching6 products
glitter5 products
liquid hand soap4 products
lip plumper4 products
body wash/cleanser4 products
mask3 products
exfoliant/scrub2 products
baby toothpaste2 products
hair styling aide2 products
2 products
facial powder2 products
makeup primer2 products
serums & essences2 products
toothpaste2 products
body powder2 products
fragrance for women2 products
mascara1 products
conditioner1 products
shampoo1 products
baby powder1 products
hair treatment/serum1 products
fragrance for men1 products
body art1 products
facial moisturizer/treatment1 products
facial cleanser1 products
nail glue1 products

Use restrictions

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CONCERN REFERENCE
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - anyOpen scientific literature
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyesFDA Color Additive Status

Persistence and bioaccumulation

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CONCERN REFERENCE
Persistent or bioaccumulative and moderate to high toxicity concern in humansOpen scientific literature
Persistent, bioaccumulative in wildlifeOpen scientific literature
Persistent, bioaccumulative in wildlifeCanada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)

Organ system toxicity (non-reproductive)

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CONCERN REFERENCE
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Classified as expected to be toxic or harmfulOpen scientific literature
Limited evidence of any toxicityScorecard.org Toxicity Information
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Irritation (skin, eyes, or lungs)

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CONCERN REFERENCE
Limited evidence of eye irritationOpen scientific literature
One or more animal studies show any irritation at high dosesOpen scientific literature

Cancer

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CONCERN REFERENCE
Cancer - weight of evidence unknown/unassessedOpen scientific literature

Developmental/reproductive toxicity

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CONCERN REFERENCE
any - weight of evidence unknown/unassessedOpen scientific literature

Endocrine disruption

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CONCERN REFERENCE
Associated with endocrine disruptionOpen scientific literature

Ecotoxicology

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CONCERN REFERENCE
Suspected to be an environmental toxin and be persistent or bioaccumulativeOpen scientific literature
Suspected to be an environmental toxin and be persistent or bioaccumulativeEnvironment Canada Domestic Substance List
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List
Wildlife and environmental toxicityOpen scientific literature
Suspected to be an environmental toxin and be persistent or bioaccumulative (uncertainty in environmental toxicity or persistence/bioaccumulation)Environment Canada Domestic Substance List
Suspected to be an environmental toxinOpen scientific literature
Uncertain environmental toxin and uncertain persistent or bioaccumulativeEnvironment Canada Domestic Substance List

Informational

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CONCERN REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyOpen scientific literature
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmeticsFDA Color Additive Status

Data gaps

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CONCERN REFERENCE
110 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed
  • Open scientific/peer reviewed literature
  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • EC (Environment Canada). 1994. Accelerated Reduction/Elimination of Toxics (ARET). ARET substance list of persistent, bioaccumulative and toxic chemicals.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED® mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST
Low Availability
Moderate Availability
High Availability

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