EWG Skin Deep® | What is CI 45410 (D&C Red No. 27 or 28)

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Data: Fair

Ci 45410 (D&C Red No. 27 Or 28)

IMAGE SOURCE: PubChem

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Other Concerns

Use restrictions (high), Endocrine disruption (low), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (low)

SYNONYMS

● 2',4',5',7'-TETRABROMO-4,5 ,6,7-TETRACHLORO-3',6'-DIHYDROXYSPIRO[ISOBENZOFURAN-1(3H),9'-[9H]XANTHEN]-3-ONE

● 2',4',5',7'-TETRABROMO-4,5,6,7-TETRACHLORO-3',6'-DIHYDROXY-

● 2',4',5',7'-TETRABROMO-4,5,6,7-TETRACHLORO-3',6'-DIHYDROXYSPIRO[ISO BENZOFURAN-1(3H),9'-[9H]XANTHEN]-3-ONE

● 2',4',5',7'-TETRABROMO-4,5,6,7-TETRACHLORO-3',6'-DIHYDROXYSPIRO[ISOBENZOFURAN-1(3H), 9'-[9H]XANTH EN]-3-ONE

● 2',4',5',7'-TETRABROMO-4,5,6,7-TETRACHLORO-3',6'-DIHYDROXYSPIRO[ISOBENZOFURAN-1(3H),9'-[9H]XANTHEN]-3-ONE, DISODIUM SALT

● 3,4,5,6-TETRACHLORO-2-(1,4,5,8-TETRABROMO-6-HYDROXY-3-OXOXANTHEN-9-YL)BENZOIC ACID

● 9'-[9H]XANTH EN]-3-ONE 2',4',5',7'-TETRABROMO-4,5,6,7-TETRACHLORO-3',6'-DIHYDROXYSPIRO[ISOBENZOFURAN-1(3H)

● ACID RED 92, DIPOTASSIUM SALT

● ACID RED 92, POTASSIUM SALT

● AKA104(1) AKA104(1)

● AKA218

● AKA231

● BENZOIC ACID, 2,3,4,5TETRACHLORO6(2,4,5,7TETRABROMO6HYDROXY3OXO3HXANTHEN9YL)

● CI 45410 (D&C RED NO. 27 OR 28)

● CI 45410 [CAS: 84473-86-9]

● CI 45410:1

● D&C RED 27

● D&C RED 28

● D&C RED NO. 27

● D&C RED NO. 28

● DIPOTASSIUM SALT ACID RED 92

● FD&C RED 28

● PHLOXINE B K SALT

● POTASSIUM SALT ACID RED 92

● RED 27

● RED 28

● SPIRO[ISOBENZOFURAN-1(3H),9'-[9H]XANTHEN]-3-ONE, 2',4',5',7'-TETRABROMO-4,5,6,7-TETRACHLORO-3',6'-DIHYDROXY-, DISODIUM SALT

Unacceptable

Unacceptable: EWG VERIFIED products cannot contain this ingredient

D&C Red 27 is a synthetic dye produced from petroleum or coal tar sources; this dye is FDA-approved for use in pharmaceuticals and cosmetics.

Common concerns

See how this product scores for common concerns.

LOW

Cancer
LOW

Allergies & Immunotoxicity
LOW

Developmental and Reproductive Toxicity
HIGH

Use Restrictions

Ingredient concerns

CONCERNS
DATA SOURCES

Products with this Ingredient

lipstick	656 products
lip gloss	185 products
nail polish	103 products
blush	86 products
lip balm	84 products
eye liner	59 products
lip liner	51 products
bath oil/salts/soak	35 products
bronzer/highlighter	26 products
lip balm with SPF	24 products
eye shadow	14 products
foundation	12 products
body oil	9 products
setting powder/spray	8 products
hair color and bleaching	6 products
lip plumper	6 products
body wash/cleanser	5 products
glitter	5 products
bar soap	3 products
liquid hand soap	3 products
hair styling aide	3 products
facial powder	2 products
mask	2 products
toothpaste	2 products
exfoliant/scrub	2 products
fragrance for women	2 products
baby toothpaste	2 products
facial moisturizer/treatment	2 products
	2 products
body powder	1 products
conditioner	1 products
shampoo	1 products
brow liner	1 products
facial cleanser	1 products
polish remover	1 products

Use restrictions

CONCERN	REFERENCE
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyes	FDA Color Additive Status
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - any	Open scientific literature

Persistence and bioaccumulation

CONCERN	REFERENCE
Persistent or bioaccumulative and moderate to high toxicity concern in humans	Open scientific literature
Persistent, bioaccumulative in wildlife	Open scientific literature
Persistent, bioaccumulative in wildlife	Canada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)

Organ system toxicity (non-reproductive)

CONCERN	REFERENCE
Classified as expected to be toxic or harmful	Environment Canada Domestic Substance List
Classified as expected to be toxic or harmful	Open scientific literature
Limited evidence of any toxicity	Scorecard.org Toxicity Information
Classified as not expected to be potentially toxic or harmful	Environment Canada Domestic Substance List

Irritation (skin, eyes, or lungs)

CONCERN	REFERENCE
Limited evidence of eye irritation	Open scientific literature
One or more animal studies show any irritation at high doses	Open scientific literature

Cancer

CONCERN	REFERENCE
Cancer - weight of evidence unknown/unassessed	Open scientific literature

Developmental/reproductive toxicity

CONCERN	REFERENCE
any - weight of evidence unknown/unassessed	Open scientific literature

Ecotoxicology

CONCERN	REFERENCE
Suspected to be an environmental toxin and be persistent or bioaccumulative	Open scientific literature
Suspected to be an environmental toxin and be persistent or bioaccumulative	Environment Canada Domestic Substance List
Wildlife and environmental toxicity	Open scientific literature
Suspected to be an environmental toxin	Open scientific literature
Suspected to be an environmental toxin and be persistent or bioaccumulative (uncertainty in environmental toxicity or persistence/bioaccumulation)	Environment Canada Domestic Substance List
Suspected to be an environmental toxin	Environment Canada Domestic Substance List
Uncertain environmental toxin and uncertain persistent or bioaccumulative	Environment Canada Domestic Substance List

Endocrine disruption

CONCERN	REFERENCE
Associated with endocrine disruption	Open scientific literature

Informational

CONCERN	REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug Administration	CTFA International Cosmetic Ingredient Dictionary and Handbook
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmetics	FDA Color Additive Status
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any	Open scientific literature

Data gaps

CONCERN	REFERENCE
110 studies in PubMed science library may include information on the toxicity of this chemical	NLM PubMed

FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
Open scientific/peer reviewed literature
EC (Environment Canada). 1994. Accelerated Reduction/Elimination of Toxics (ARET). ARET substance list of persistent, bioaccumulative and toxic chemicals.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

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