Menu Close Menu

Menu

D&C RED 27

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Endocrine disruption (low), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

Expand content Collapse content
lipstick73 products
eye liner70 products
lip balm19 products
bath oil/salts/soak18 products
lip gloss11 products
lip balm with SPF7 products
blush3 products
hair color and bleaching2 products
bar soap1 products
mask1 products
moisturizer1 products
bronzer/highlighter1 products
shaving cream1 products
shampoo1 products

Use restrictions

Expand content Collapse content
Concern Reference
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive not approved by FDA for cosmetics used around eyesFDA Color Additive Status

Persistence and bioaccumulation

Expand content Collapse content
Concern Reference
Persistent, bioaccumulative in wildlifeCanada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)

Organ system toxicity (non-reproductive)

Expand content Collapse content
Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List

Irritation (skin, eyes, or lungs)

Expand content Collapse content
Concern Reference
Limited evidence of eye irritationEuropean Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website
Irritating to the rabbit eye.Scientific Committee on Consumer Safety (SCCS) 2012. Opinion on Acid Red 92.

Cancer

Expand content Collapse content
Concern Reference
Increased incidence of pituitary tumors in mice. Mutagenicity observed in a bacerial cell assay but not mammalian tests (in vitro or in vivo).Scientific Committee on Consumer Safety (SCCS) 2012. Opinion on Acid Red 92.

Developmental/reproductive toxicity

Expand content Collapse content
Concern Reference
Limited evidence of teratogenicity in dietary exposure studies in mice.Scientific Committee on Consumer Safety (SCCS) 2012. Opinion on Acid Red 92.

Ecotoxicology

Expand content Collapse content
Concern Reference
Suspected to be an environmental toxin and be persistent or bioaccumulativeEnvironment Canada Domestic Substance List
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List
Wildlife and environmental toxicityEuropean Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website

Endocrine disruption

Expand content Collapse content
Concern Reference
Modeling suggests this substance may interact with the androgen receptor.National Toxicology Program (NTP) 2020. EWG Toxcast Analysis. Appears as: CAS: 13473-26-2; Chemical_Name: AKA218

Data gaps

Expand content Collapse content
Concern Reference
110 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

Expand content Collapse content
Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmeticsFDA Color Additive Status
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook

Data Sources

  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • EC (Environment Canada). 1994. Accelerated Reduction/Elimination of Toxics (ARET). ARET substance list of persistent, bioaccumulative and toxic chemicals.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website
  • Scientific Committee on Consumer Safety (SCCS) 2012. Opinion on Acid Red 92.
  • National Toxicology Program (NTP) 2020. EWG Toxcast Analysis. Appears as: CAS: 13473-26-2; Chemical_Name: AKA218
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products intended for use around the eyes due to increased risk of absorption.
  • Products with the EWG VERIFIED mark have met use restrictions and warnings based on EWG review of company data.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

ABOUT EWG VERIFIED™

Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer