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CI 45380 (D&C Red No. 21 or 22) Lake
Score:
Data: None
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (high), Endocrine disruption (low), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (low)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| lipstick | 446 products |
| lip gloss | 89 products |
| lip balm | 50 products |
| lip liner | 44 products |
| blush | 28 products |
| bronzer/highlighter | 1 products |
| exfoliant/scrub | 1 products |
Use restrictions
| Concern | Reference |
|---|---|
| Prohibited in European cosmetics: must not form part of the composition of hair dye products | EU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-31631; Chemical_Name: ACID RED 87; ; CAS: 17372-87-1 |
| Color additive not approved by FDA for cosmetics used around eyes | US. Food and Drug Administration (FDA). 2015. Color Additive Status. Appears as: listid: COLOR-119; Chemical_Name: D&C Red 22; ; |
| Determined safe for use in cosmetics, subject to concentration or use limitations - any | FDA Color Additive Status |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| This chemical was flagged for further attention by CEPA due to suspected aquatic toxicity, persistence and bioaccumulation | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-08589; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-; ; CAS: 15086-94-9 |
| Limited evidence of any toxicity | Klaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull |
| This chemical was NOT flagged by CEPA for further attention. Flagged for suspected persistence. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-02943; Chemical_Name: CI 45380; ; CAS: 548-26-5 |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| May cause an allergic skin reaction. | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate; disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate; -; 2-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl); C.I. ACID RED 87; disodium 2-(2,4,5,7-tetrabromo-3-oxido; cas_numbers: 17372-87-1 |
| A peer-reviewed article reports this substance caused allergic contact dermatitis in humans. | R Tomb. 1991. Allergic contact dermatitis from eosin. Contact dermatitis 24(1), 27-9. |
Irritation (skin, eyes, or lungs)
| Concern | Reference |
|---|---|
| Causes serious eye irritation. | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate; disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate; -; 2-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl); C.I. ACID RED 87; disodium 2-(2,4,5,7-tetrabromo-3-oxido; cas_numbers: 17372-87-1 |
Ecotoxicology
| Concern | Reference |
|---|---|
| This chemical was flagged for further attention by CEPA due to suspected aquatic toxicity, persistence and bioaccumulation. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-08589; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-; ; CAS: 15086-94-9 |
| This chemical was flagged for further attention by CEPA due to suspected aquatic toxicity, persistence and bioaccumulation. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-08589; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-; ; CAS: 15086-94-9 |
| This chemical was NOT flagged by CEPA for further attention. Flagged for suspected persistence. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-02943; Chemical_Name: CI 45380; ; CAS: 548-26-5 |
Endocrine disruption
| Concern | Reference |
|---|---|
| Evidence of endocrine activity from cellular assays and models. | National Toxicology Program (NTP) 2015. EWG Toxcast Analysis. Appears as: CAS: 17372-87-1; Chemical_Name: Eosin |
Cancer
| Concern | Reference |
|---|---|
| IARC Group 3 (no cancer link) | International Agency for Research on Cancer (IARC) 2012. Agents classified by the IARC Monographs (through Volume 127). Appears as: CAS: 15086-94-9; Name: Eosin |
Data gaps
| Concern | Reference |
|---|---|
| 0 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Informational
| Concern | Reference |
|---|---|
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives Lakes - Batch Certified by the U.S. Food and Drug Administration | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| his chemical was NOT flagged by CEPA for further attention. Flagged for suspected persistence. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-02943; Chemical_Name: CI 45380; ; CAS: 548-26-5 |
Data Sources
- EU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-31631; Chemical_Name: ACID RED 87; ; CAS: 17372-87-1
- US. Food and Drug Administration (FDA). 2015. Color Additive Status. Appears as: listid: COLOR-119; Chemical_Name: D&C Red 22; ;
- FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
- Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-08589; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-; ; CAS: 15086-94-9
- Klaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull
- Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-02943; Chemical_Name: CI 45380; ; CAS: 548-26-5
- European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate; disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate; -; 2-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl); C.I. ACID RED 87; disodium 2-(2,4,5,7-tetrabromo-3-oxido; cas_numbers: 17372-87-1
- R Tomb. 1991. Allergic contact dermatitis from eosin. Contact dermatitis 24(1), 27-9.
- Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-08589; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-; ; CAS: 15086-94-9
- Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-02943; Chemical_Name: CI 45380; ; CAS: 548-26-5
- National Toxicology Program (NTP) 2015. EWG Toxcast Analysis. Appears as: CAS: 17372-87-1; Chemical_Name: Eosin
- International Agency for Research on Cancer (IARC) 2012. Agents classified by the IARC Monographs (through Volume 127). Appears as: CAS: 15086-94-9; Name: Eosin
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
- Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-02943; Chemical_Name: CI 45380; ; CAS: 548-26-5
- This ingredient’s score is higher if used in products that are inhalable (e.g., sprays, powders) because of respiratory concerns.
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