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Data: None

Ci 45380 (D&C Red No. 21 Or 22) Lake

Other Concerns

Use restrictions (high), Endocrine disruption (low), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (low)

SYNONYMS

CI 45380 (D&C RED NO. 21 OR 22) LAKE, D&C RED 21 AL LAKE, D&C RED 21 ALUMINUM LAKE, D&C RED 21 LAKE, D&C RED 21 ZR LAKE, D&C RED 22 AL LAKE, D&C RED 22 ALUMINUM LAKE, D&C RED NO. 21 AL LAKE, D&C RED NO. 21 ALUMINUM LAKE, D&C RED NO. 21 ZIRCONIUM LAKE, D&C RED NO. 21 ZR LAKE, D&C RED NO. 22 AL LAKE, D&C RED NO. 22 ALUMINUM LAKE, DC RED #21-ALUMINUM BENZOATE LAKE, RED 21 ALUMINUM LAKE, RED 21 LAKE, RED 22 ALUMINUM LAKE, and RED 22 LAKE

Restricted

Restricted: EWG VERIFIED products cannot contain this ingredient without adequate substantiation


In industrial production of colorants, the term 'lake' is applied to pigments or dyes that are precipitated with metal salts such as aluminum, calcium, barium, or others. Most lake pigments are synthetically produced from coal tar or petroleum.

Common concerns

See how this product scores for common concerns.

  • LOW
    Cancer
  • LOW
    Allergies & Immunotoxicity
  • LOW
    Developmental and Reproductive Toxicity
  • HIGH
    Use Restrictions

Ingredient concerns

  • CONCERNS
  • DATA SOURCES

Products with this Ingredient

Expand content Collapse content
lipstick382 products
lip balm133 products
lip gloss110 products
blush27 products
lip liner26 products
body oil9 products
lip plumper6 products
bronzer/highlighter6 products
eye shadow4 products
2 products
lip balm with SPF1 products
makeup primer1 products

Use restrictions

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CONCERN REFERENCE
Violation of government restrictions - Banned or found unsafe for use in cosmeticsOpen scientific literature
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - anyOpen scientific literature
Determined safe for use in cosmetics, subject to concentration or use limitations - anyFDA Color Additive Status

Organ system toxicity (non-reproductive)

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CONCERN REFERENCE
Classified as expected to be toxic or harmfulOpen scientific literature
Limited evidence of any toxicityScorecard.org Toxicity Information
Classified as not expected to be potentially toxic or harmfulOpen scientific literature

Irritation (skin, eyes, or lungs)

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CONCERN REFERENCE
Limited evidence of any irritationOpen scientific literature

Allergies/immunotoxicity

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CONCERN REFERENCE
Limited evidence of any toxicity or allergiesOpen scientific literature
One or more human case studies show equivocal any or allergenic effectsOpen scientific literature

Endocrine disruption

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CONCERN REFERENCE
Associated with endocrine disruptionOpen scientific literature

Ecotoxicology

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CONCERN REFERENCE
Suspected to be an environmental toxin and be persistent or bioaccumulativeOpen scientific literature
Suspected to be an environmental toxinOpen scientific literature
Not suspected to be an environmental toxinOpen scientific literature

Cancer

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CONCERN REFERENCE
Not likely to be carcinogenic in humansOpen scientific literature

Persistence and bioaccumulation

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CONCERN REFERENCE
Not suspected to be bioaccumulativeOpen scientific literature

Informational

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CONCERN REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives Lakes - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook

Data gaps

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CONCERN REFERENCE
0 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed
  • Open scientific/peer reviewed literature
  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST
Low Availability
Moderate Availability
High Availability

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