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CI 45380 (D&C Red No. 21 or 22) Lake

Score:

Data: None

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Endocrine disruption (low), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lipstick446 products
lip gloss89 products
lip balm50 products
lip liner44 products
blush28 products
bronzer/highlighter1 products
exfoliant/scrub1 products

Use restrictions

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Concern Reference
Prohibited in European cosmetics: must not form part of the composition of hair dye productsEU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-31631; Chemical_Name: ACID RED 87; ; CAS: 17372-87-1
Color additive not approved by FDA for cosmetics used around eyesUS. Food and Drug Administration (FDA). 2015. Color Additive Status. Appears as: listid: COLOR-119; Chemical_Name: D&C Red 22; ;
Determined safe for use in cosmetics, subject to concentration or use limitations - anyFDA Color Additive Status

Organ system toxicity (non-reproductive)

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Concern Reference
This chemical was flagged for further attention by CEPA due to suspected aquatic toxicity, persistence and bioaccumulationEnvironment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-08589; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-; ; CAS: 15086-94-9
Limited evidence of any toxicityKlaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull
This chemical was NOT flagged by CEPA for further attention. Flagged for suspected persistence.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-02943; Chemical_Name: CI 45380; ; CAS: 548-26-5

Allergies/immunotoxicity

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Concern Reference
May cause an allergic skin reaction.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate; disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate; -; 2-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl); C.I. ACID RED 87; disodium 2-(2,4,5,7-tetrabromo-3-oxido; cas_numbers: 17372-87-1
A peer-reviewed article reports this substance caused allergic contact dermatitis in humans.R Tomb. 1991. Allergic contact dermatitis from eosin. Contact dermatitis 24(1), 27-9.

Irritation (skin, eyes, or lungs)

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Concern Reference
Causes serious eye irritation.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate; disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate; -; 2-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl); C.I. ACID RED 87; disodium 2-(2,4,5,7-tetrabromo-3-oxido; cas_numbers: 17372-87-1

Ecotoxicology

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Concern Reference
This chemical was flagged for further attention by CEPA due to suspected aquatic toxicity, persistence and bioaccumulation.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-08589; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-; ; CAS: 15086-94-9
This chemical was flagged for further attention by CEPA due to suspected aquatic toxicity, persistence and bioaccumulation.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-08589; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-; ; CAS: 15086-94-9
This chemical was NOT flagged by CEPA for further attention. Flagged for suspected persistence.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-02943; Chemical_Name: CI 45380; ; CAS: 548-26-5

Endocrine disruption

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Concern Reference
Evidence of endocrine activity from cellular assays and models.National Toxicology Program (NTP) 2015. EWG Toxcast Analysis. Appears as: CAS: 17372-87-1; Chemical_Name: Eosin

Cancer

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Concern Reference
IARC Group 3 (no cancer link)International Agency for Research on Cancer (IARC) 2012. Agents classified by the IARC Monographs (through Volume 127). Appears as: CAS: 15086-94-9; Name: Eosin

Data gaps

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Concern Reference
0 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives Lakes - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook

Persistence and bioaccumulation

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Concern Reference
his chemical was NOT flagged by CEPA for further attention. Flagged for suspected persistence.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-02943; Chemical_Name: CI 45380; ; CAS: 548-26-5

Data Sources

  • EU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-31631; Chemical_Name: ACID RED 87; ; CAS: 17372-87-1
  • US. Food and Drug Administration (FDA). 2015. Color Additive Status. Appears as: listid: COLOR-119; Chemical_Name: D&C Red 22; ;
  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-08589; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-; ; CAS: 15086-94-9
  • Klaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull
  • Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-02943; Chemical_Name: CI 45380; ; CAS: 548-26-5
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate; disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate; -; 2-(2,4,5,7-tetrabromo-6-oxido-3-oxo-3H-xanthen-9-yl); C.I. ACID RED 87; disodium 2-(2,4,5,7-tetrabromo-3-oxido; cas_numbers: 17372-87-1
  • R Tomb. 1991. Allergic contact dermatitis from eosin. Contact dermatitis 24(1), 27-9.
  • Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-08589; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 2',4',5',7'-tetrabromo-3',6'-dihydroxy-; ; CAS: 15086-94-9
  • Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-02943; Chemical_Name: CI 45380; ; CAS: 548-26-5
  • National Toxicology Program (NTP) 2015. EWG Toxcast Analysis. Appears as: CAS: 17372-87-1; Chemical_Name: Eosin
  • International Agency for Research on Cancer (IARC) 2012. Agents classified by the IARC Monographs (through Volume 127). Appears as: CAS: 15086-94-9; Name: Eosin
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
  • Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-02943; Chemical_Name: CI 45380; ; CAS: 548-26-5

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products that are inhalable (e.g., sprays, powders) because of respiratory concerns.

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