EWG Skin Deep® | What is CI 45380 (D&C Red No. 21 or 22) Lake

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Data: None

Ci 45380 (D&C Red No. 21 Or 22) Lake

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Other Concerns

Use restrictions (high), Endocrine disruption (low), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (low)

SYNONYMS

● CI 45380 (D&C RED NO. 21 OR 22) LAKE

● D&C RED 21 AL LAKE

● D&C RED 21 ALUMINUM LAKE

● D&C RED 21 LAKE

● D&C RED 21 ZR LAKE

● D&C RED 22 AL LAKE

● D&C RED 22 ALUMINUM LAKE

● D&C RED NO. 21 AL LAKE

● D&C RED NO. 21 ALUMINUM LAKE

● D&C RED NO. 21 ZIRCONIUM LAKE

● D&C RED NO. 21 ZR LAKE

● D&C RED NO. 22 AL LAKE

● D&C RED NO. 22 ALUMINUM LAKE

● DC RED #21-ALUMINUM BENZOATE LAKE

● RED 21 ALUMINUM LAKE

● RED 21 LAKE

● RED 22 ALUMINUM LAKE

● RED 22 LAKE

Unacceptable

Unacceptable: EWG VERIFIED products cannot contain this ingredient

In industrial production of colorants, the term 'lake' is applied to pigments or dyes that are precipitated with metal salts such as aluminum, calcium, barium, or others. Most lake pigments are synthetically produced from coal tar or petroleum.

Common concerns

See how this product scores for common concerns.

LOW

Cancer
LOW

Allergies & Immunotoxicity
LOW

Developmental and Reproductive Toxicity
HIGH

Use Restrictions

Ingredient concerns

CONCERNS
DATA SOURCES

Products with this Ingredient

lipstick	401 products
lip gloss	156 products
lip balm	67 products
lip liner	49 products
blush	41 products
lip plumper	10 products
body oil	9 products
bronzer/highlighter	7 products
eye shadow	4 products
nail polish	1 products
makeup primer	1 products

Use restrictions

CONCERN	REFERENCE
Violation of government restrictions - Banned or found unsafe for use in cosmetics	Open scientific literature
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - any	Open scientific literature
Determined safe for use in cosmetics, subject to concentration or use limitations - any	FDA Color Additive Status

Organ system toxicity (non-reproductive)

CONCERN	REFERENCE
Classified as expected to be toxic or harmful	Open scientific literature
Limited evidence of any toxicity	Scorecard.org Toxicity Information
Classified as not expected to be potentially toxic or harmful	Open scientific literature

Irritation (skin, eyes, or lungs)

CONCERN	REFERENCE
Limited evidence of any irritation	Open scientific literature

Allergies/immunotoxicity

CONCERN	REFERENCE
Limited evidence of any toxicity or allergies	Open scientific literature
One or more human case studies show equivocal any or allergenic effects	Open scientific literature

Endocrine disruption

CONCERN	REFERENCE
Associated with endocrine disruption	Open scientific literature

Ecotoxicology

CONCERN	REFERENCE
Suspected to be an environmental toxin and be persistent or bioaccumulative	Open scientific literature
Suspected to be an environmental toxin	Open scientific literature
Not suspected to be an environmental toxin	Open scientific literature

Cancer

CONCERN	REFERENCE
Not likely to be carcinogenic in humans	Open scientific literature

Persistence and bioaccumulation

CONCERN	REFERENCE
Not suspected to be bioaccumulative	Open scientific literature

Informational

CONCERN	REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives Lakes - Batch Certified by the U.S. Food and Drug Administration	CTFA International Cosmetic Ingredient Dictionary and Handbook

Data gaps

CONCERN	REFERENCE
0 studies in PubMed science library may include information on the toxicity of this chemical	NLM PubMed

Open scientific/peer reviewed literature
FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED^® mark means a product meets EWG’s strictest criteria for transparency and health.

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST

Low Availability

Moderate Availability

High Availability