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CI 45380 (D&C Red No. 21 or 22) Lake

Score:

Data: None

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (high), Endocrine disruption (low), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lipstick477 products
lip gloss106 products
lip balm79 products
lip liner36 products
blush33 products
eye shadow4 products
1 products
bath oil/salts/soak1 products
hair color and bleaching1 products
exfoliant/scrub1 products
bronzer/highlighter1 products

Use restrictions

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Concern Reference
Violation of government restrictions - Banned or found unsafe for use in cosmeticsOpen scientific literature
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - anyOpen scientific literature
Determined safe for use in cosmetics, subject to concentration or use limitations - anyFDA Color Additive Status

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as expected to be toxic or harmfulOpen scientific literature
Limited evidence of any toxicityScorecard.org Toxicity Information
Classified as not expected to be potentially toxic or harmfulOpen scientific literature

Irritation (skin, eyes, or lungs)

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Concern Reference
Limited evidence of any irritationOpen scientific literature

Allergies/immunotoxicity

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Concern Reference
Limited evidence of any toxicity or allergiesOpen scientific literature
One or more human case studies show equivocal any or allergenic effectsOpen scientific literature

Endocrine disruption

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Concern Reference
Associated with endocrine disruptionOpen scientific literature

Ecotoxicology

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Concern Reference
Suspected to be an environmental toxin and be persistent or bioaccumulativeOpen scientific literature
Suspected to be an environmental toxinOpen scientific literature
Not suspected to be an environmental toxinOpen scientific literature

Cancer

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Concern Reference
Not likely to be carcinogenic in humansOpen scientific literature

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeOpen scientific literature

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives Lakes - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook

Data gaps

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Concern Reference
0 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Data Sources

  • Open scientific/peer reviewed literature
  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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