Menu
D&C ORANGE 5 (CI 45370) LAKE
Score:
Data: None
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (high), Endocrine disruption (low), Non-reproductive organ system toxicity (moderate), and Ecotoxicology (low)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| lipstick | 111 products |
| lip liner | 7 products |
| lip gloss | 6 products |
| blush | 1 products |
| bath oil/salts/soak | 1 products |
Use restrictions
| Concern | Reference |
|---|---|
| Color additive not approved by FDA for cosmetics used around eyes | US. Food and Drug Administration (FDA). 2015. Color Additive Status. Appears as: listid: COLOR-018; Chemical_Name: D&C Orange 5; ; |
| Determined safe for use in cosmetics, subject to concentration or use limitations - any | FDA Color Additive Status |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| This chemical was flagged for further attention by CEPA due to suspected aquatic toxicity and bioaccumulation. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-03140; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-; ; CAS: 596-03-2 |
| Limited evidence of any toxicity | Klaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull |
Ecotoxicology
| Concern | Reference |
|---|---|
| This chemical was flagged for further attention by CEPA due to suspected aquatic toxicity and bioaccumulation. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-03140; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-; ; CAS: 596-03-2 |
| This chemical was flagged for further attention by CEPA due to suspected aquatic toxicity and bioaccumulation. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-03140; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-; ; CAS: 596-03-2 |
Endocrine disruption
| Concern | Reference |
|---|---|
| Possible endocrine activity suggested by cellular assays and models. | National Toxicology Program (NTP) 2020. EWG Toxcast Analysis. Appears as: ; Chemical_Name: D&C Orange No. 5 |
Data gaps
| Concern | Reference |
|---|---|
| 0 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Informational
| Concern | Reference |
|---|---|
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives Lakes - Batch Certified by the U.S. Food and Drug Administration | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| This chemical was flagged for further attention by CEPA due to suspected aquatic toxicity and bioaccumulation. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-03140; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-; ; CAS: 596-03-2 |
Data Sources
- US. Food and Drug Administration (FDA). 2015. Color Additive Status. Appears as: listid: COLOR-018; Chemical_Name: D&C Orange 5; ;
- FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
- Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-03140; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-; ; CAS: 596-03-2
- Klaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull
- National Toxicology Program (NTP) 2020. EWG Toxcast Analysis. Appears as: ; Chemical_Name: D&C Orange No. 5
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
ABOUT THE SKIN DEEP® RATINGS
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
ABOUT EWG VERIFIED™
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer
