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D&C ORANGE 5 (CI 45370) LAKE
Score:
Data: None
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (high), Endocrine disruption (low), Non-reproductive organ system toxicity (moderate), and Ecotoxicology (low)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| lipstick | 36 products |
| lip gloss | 4 products |
| blush | 1 products |
Use restrictions
| Concern | Reference |
|---|---|
| Color additive not approved by FDA for cosmetics used around eyes | US. Food and Drug Administration (FDA). 2015. Color Additive Status. Appears as: listid: COLOR-018; Chemical_Name: D&C Orange 5; ; |
| Determined safe for use in cosmetics, subject to concentration or use limitations - any | FDA Color Additive Status |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| This chemical was flagged for further attention by CEPA due to suspected aquatic toxicity and bioaccumulation. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-03140; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-; ; CAS: 596-03-2 |
| Limited evidence of any toxicity | Klaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull |
Ecotoxicology
| Concern | Reference |
|---|---|
| This chemical was flagged for further attention by CEPA due to suspected aquatic toxicity and bioaccumulation. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-03140; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-; ; CAS: 596-03-2 |
| This chemical was flagged for further attention by CEPA due to suspected aquatic toxicity and bioaccumulation. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-03140; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-; ; CAS: 596-03-2 |
Endocrine disruption
| Concern | Reference |
|---|---|
| Possible endocrine activity suggested by cellular assays and models. | National Toxicology Program (NTP) 2020. EWG Toxcast Analysis. Appears as: ; Chemical_Name: D&C Orange No. 5 |
Data gaps
| Concern | Reference |
|---|---|
| 0 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Informational
| Concern | Reference |
|---|---|
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives Lakes - Batch Certified by the U.S. Food and Drug Administration | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| This chemical was flagged for further attention by CEPA due to suspected aquatic toxicity and bioaccumulation. | Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-03140; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-; ; CAS: 596-03-2 |
Data Sources
- US. Food and Drug Administration (FDA). 2015. Color Additive Status. Appears as: listid: COLOR-018; Chemical_Name: D&C Orange 5; ;
- FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
- Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-03140; Chemical_Name: Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 4',5'-dibromo-3',6'-dihydroxy-; ; CAS: 596-03-2
- Klaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull
- National Toxicology Program (NTP) 2020. EWG Toxcast Analysis. Appears as: ; Chemical_Name: D&C Orange No. 5
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
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