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Data: Fair

D&C Orange No. 4 (Ci 15510)

  • This ingredient’s score is higher if used in products intended for damaged skin due to increased risk of absorption.
  • This ingredient’s score is higher if used in products intended for use around mouth due to increased risk of ingestion and absorption.
  • This ingredient’s score is higher if used in products intended for use on lips due to increased risk of ingestion and absorption.
  • This ingredient’s score is higher if used in products intended for use around the eyes due to increased risk of absorption.
  • Products with the EWG VERIFIED mark have met use restrictions and warnings based on EWG review of company data.

IMAGE SOURCE: PubChem

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Other Concerns

Use restrictions (high), Endocrine disruption (low), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), and Irritation (skin, eyes, or lungs) (low)

SYNONYMS

● 4-((2-HYDROXY-1-NAPHTHALENYL)AZO)-BENZENESULFONIC ACID, MONOSODIUM SALT
● 4-[(2-HYDROXY-1-NAPHTHYL)AZO]BENZENESULFONIC ACID, SODIUM SALT
● ACID ORANGE 7, MONOSODIUM SALT
● BENZENESULFONIC ACID, 4[(2HYDROXY1NAPHTHALENYL)AZO], MONOSODIUM SALT
● CI 15510
● D&C ORANGE 4
● D&C ORANGE NO. 4
● D&C ORANGE NO. 4 (CI 15510)
● FD&C ORANGE 4
● MONOSODIUM SALT ACID ORANGE 7
● NAPHTHOL ORANGE
● ORANGE 2 SODIUM SALT
● ORANGE 4
● ORANGE N O. 205
● SODIUM 4-[(2-HYDROXY-1-NAPHTHYL)AZO]BENZENESULPHONATE

Restricted

Restricted: EWG VERIFIED products cannot contain this ingredient without adequate substantiation


Orange 4 is classed chemically as a monoazo color.

Common concerns

See how this product scores for common concerns.

  • LOW
    Cancer
  • LOW
    Allergies & Immunotoxicity
  • LOW
    Developmental and Reproductive Toxicity
  • HIGH
    Use Restrictions

Ingredient concerns

  • CONCERNS
  • DATA SOURCES

Products with this Ingredient

Expand content Collapse content
bar soap19 products
shampoo18 products
moisturizer16 products
conditioner12 products
hair styling aide8 products
hair color and bleaching8 products
lipstick7 products
body wash/cleanser7 products
liquid hand soap6 products
facial cleanser6 products
mask5 products
sunless tanning5 products
styling gel/lotion4 products
hair treatment/serum4 products
blush3 products
body spray3 products
exfoliant/scrub3 products
after shave3 products
fragrance for men3 products
fragrance for women2 products
serums & essences2 products
toners/astringents2 products
hand cream1 products
vapor rubs1 products
bubble bath1 products
hair spray1 products
shaving cream (men's)1 products
1 products
nail treatment1 products
facial moisturizer/treatment1 products
baby shampoo1 products
cuticle treatment1 products
bath oil/salts/soak1 products

Use restrictions

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CONCERN REFERENCE
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - Color additive approved by FDA for use in cosmetics: external use onlyFDA Color Additive Status
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - anyOpen scientific literature

Persistence and bioaccumulation

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CONCERN REFERENCE
Persistent or bioaccumulative and moderate to high toxicity concern in humansEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

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CONCERN REFERENCE
Classified as medium human health priorityEnvironment Canada Domestic Substance List
Classified as toxic or harmful.Open scientific literature
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Irritation (skin, eyes, or lungs)

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CONCERN REFERENCE
Limited evidence of any irritationOpen scientific literature

Endocrine disruption

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CONCERN REFERENCE
Associated with endocrine disruptionOpen scientific literature

Ecotoxicology

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CONCERN REFERENCE
Wildlife and environmental toxicityOpen scientific literature
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Informational

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CONCERN REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color Additives - Batch Certified by the U.S. Food and Drug AdministrationCTFA International Cosmetic Ingredient Dictionary and Handbook
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Color additive approved by FDA for use in cosmetics: external use onlyFDA Color Additive Status

Data gaps

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CONCERN REFERENCE
640 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed
  • FDA (U.S. Food and Drug Administration) 2006. Center for Food Safety and Applied Nutrition. Color Additive Status List. September 2006.
  • Open scientific/peer reviewed literature
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED® mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST
Low Availability
Moderate Availability
High Availability

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