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CYCLOPENTASILOXANE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Neurotoxicity (low), Endocrine disruption (low), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), and Ecotoxicology (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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foundation909 products
lipstick542 products
concealer420 products
eye shadow238 products
eye liner206 products
moisturizer with SPF171 products
antiperspirant/deodorant134 products
hair treatment/serum114 products
conditioner110 products
lip liner99 products
makeup primer98 products
beach & sport sunscreen79 products
serums & essences77 products
blush74 products
facial moisturizer/treatment70 products
antiperspirant/deodorant (men's)69 products
moisturizer63 products
brow liner54 products
BB cream41 products
mask40 products
hair spray34 products
bronzer/highlighter32 products
mascara32 products
hair styling aide32 products
CC cream31 products
shampoo30 products
makeup remover24 products
body firming lotion22 products
around-eye cream21 products
lip gloss21 products
lip balm with SPF20 products
hand cream17 products
15 products
detangler10 products
facial cleanser9 products
styling gel/lotion9 products
eye makeup remover9 products
facial powder8 products
other eye makeup7 products
anti-aging6 products
styling mousse/foam5 products
baby oil5 products
after shave4 products
body oil4 products
hair color and bleaching3 products
body wash/cleanser3 products
baby sunscreen3 products
hair relaxer3 products
body spray2 products
beard care2 products
oil controller2 products
sunless tanning2 products
toners/astringents1 products
lip balm1 products
tanning oil1 products
fragrance for men1 products
shaving cream (men's)1 products
beard oil1 products

Persistence and bioaccumulation

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Concern Reference
Persistent, bioaccumulative in wildlifeCanada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List

Cancer

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Concern Reference
Uterine tumors in female ratsDow Corning Corporation 2005. Decamethylcyclopentasiloxane: A 24-month combined chronic toxicity and oncogenicity whole body vapor inhalation study in Fischer-344 rats. Dow Corning Report No. 2005-1000-54953. 4062.

Endocrine disruption

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Concern Reference
Increased anogenital distance observed in rats at a moderate dose.Siddiqui WH, Stump DG, Reynolds VL, Plotzke KP, Holson JF, Meeks RG 2007. A two- generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation. Reprod Toxicol. 23(2):216-25.

Neurotoxicity

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Concern Reference
Moderate dose in rate suggested dopamine D2-receptor behavior on pituitary cells.Jean PA, McCracken KA, Arthurton JA, Plotzke KP 2005b. Investigation of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) as dopamine D2- receptor agonists. Toxicologist 84(S-1):370.

Ecotoxicology

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Concern Reference
Suspected to be an environmental toxin and be persistent or bioaccumulativeEnvironment Canada Domestic Substance List
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
119 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Data Sources

  • EC (Environment Canada). 1994. Accelerated Reduction/Elimination of Toxics (ARET). ARET substance list of persistent, bioaccumulative and toxic chemicals.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Dow Corning Corporation 2005. Decamethylcyclopentasiloxane: A 24-month combined chronic toxicity and oncogenicity whole body vapor inhalation study in Fischer-344 rats. Dow Corning Report No. 2005-1000-54953. 4062.
  • Siddiqui WH, Stump DG, Reynolds VL, Plotzke KP, Holson JF, Meeks RG 2007. A two- generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation. Reprod Toxicol. 23(2):216-25.
  • Jean PA, McCracken KA, Arthurton JA, Plotzke KP 2005b. Investigation of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) as dopamine D2- receptor agonists. Toxicologist 84(S-1):370.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.

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