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CYCLOPENTASILOXANE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Neurotoxicity (low), Endocrine disruption (low), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), and Ecotoxicology (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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foundation1276 products
lipstick641 products
concealer608 products
eye shadow292 products
antiperspirant/deodorant291 products
eye liner260 products
daily use with SPF204 products
hair treatment/serum179 products
conditioner174 products
lip liner155 products
makeup primer122 products
facial moisturizer/treatment109 products
antiperspirant/deodorant (men's)108 products
moisturizer108 products
recreational sunscreen103 products
brow liner94 products
blush89 products
CC cream84 products
BB cream62 products
mask57 products
hair spray56 products
mascara52 products
hair styling aide48 products
bronzer/highlighter45 products
lip gloss41 products
shampoo39 products
serums & essences38 products
makeup remover37 products
around-eye cream33 products
body firming lotion31 products
hand cream26 products
26 products
styling gel/lotion22 products
anti-aging20 products
lip balm with SPF18 products
eye makeup remover17 products
facial powder16 products
detangler16 products
baby sunscreen10 products
styling mousse/foam9 products
sunless tanning9 products
facial cleanser8 products
other eye makeup7 products
hair color and bleaching6 products
body oil6 products
beard oil6 products
after shave5 products
baby oil5 products
toners/astringents5 products
body wash/cleanser5 products
lip balm4 products
hair relaxer4 products
bath oil/salts/soak4 products
foot moisturizer3 products
tanning oil3 products
skin fading/lightener2 products
body spray2 products
beard care2 products
body art2 products
oil controller1 products
exfoliant/scrub1 products
shaving cream (men's)1 products
nail treatment1 products
glitter1 products
after sun product1 products
baby lotion1 products
fragrance for women1 products
shaving cream1 products
fragrance for men1 products
setting powder/spray1 products

Persistence and bioaccumulation

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Concern Reference
Persistent, bioaccumulative in wildlifeCanada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List

Cancer

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Concern Reference
Uterine tumors in female ratsDow Corning Corporation 2005. Decamethylcyclopentasiloxane: A 24-month combined chronic toxicity and oncogenicity whole body vapor inhalation study in Fischer-344 rats. Dow Corning Report No. 2005-1000-54953. 4062.

Endocrine disruption

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Concern Reference
Increased anogenital distance observed in rats at a moderate dose.Siddiqui WH, Stump DG, Reynolds VL, Plotzke KP, Holson JF, Meeks RG 2007. A two- generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation. Reprod Toxicol. 23(2):216-25.

Neurotoxicity

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Concern Reference
Moderate dose in rate suggested dopamine D2-receptor behavior on pituitary cells.Jean PA, McCracken KA, Arthurton JA, Plotzke KP 2005b. Investigation of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) as dopamine D2- receptor agonists. Toxicologist 84(S-1):370.

Ecotoxicology

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Concern Reference
Suspected to be an environmental toxin and be persistent or bioaccumulativeEnvironment Canada Domestic Substance List
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
119 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Data Sources

  • EC (Environment Canada). 1994. Accelerated Reduction/Elimination of Toxics (ARET). ARET substance list of persistent, bioaccumulative and toxic chemicals.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Dow Corning Corporation 2005. Decamethylcyclopentasiloxane: A 24-month combined chronic toxicity and oncogenicity whole body vapor inhalation study in Fischer-344 rats. Dow Corning Report No. 2005-1000-54953. 4062.
  • Siddiqui WH, Stump DG, Reynolds VL, Plotzke KP, Holson JF, Meeks RG 2007. A two- generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation. Reprod Toxicol. 23(2):216-25.
  • Jean PA, McCracken KA, Arthurton JA, Plotzke KP 2005b. Investigation of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) as dopamine D2- receptor agonists. Toxicologist 84(S-1):370.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.

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