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CYCLOPENTASILOXANE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Neurotoxicity (low), Endocrine disruption (low), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), and Ecotoxicology (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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foundation533 products
lipstick335 products
concealer228 products
moisturizer with SPF157 products
eye liner115 products
eye shadow80 products
beach & sport sunscreen77 products
lip liner64 products
serums & essences60 products
makeup primer47 products
antiperspirant/deodorant43 products
conditioner41 products
blush39 products
brow liner32 products
facial moisturizer/treatment30 products
moisturizer23 products
BB cream22 products
hair treatment/serum20 products
makeup remover17 products
around-eye cream16 products
CC cream16 products
mask14 products
antiperspirant/deodorant (men's)13 products
mascara13 products
lip balm with SPF12 products
bronzer/highlighter12 products
shampoo10 products
hair spray9 products
other eye makeup7 products
hair styling aide6 products
eye makeup remover5 products
styling gel/lotion5 products
detangler4 products
after shave4 products
anti-aging3 products
hand cream3 products
baby sunscreen3 products
hair color and bleaching2 products
lip gloss2 products
body firming lotion2 products
facial cleanser2 products
facial powder2 products
oil controller2 products
makeup with SPF1 products
baby oil1 products
tanning oil1 products
fragrance for men1 products
body oil1 products
beard oil1 products
toners/astringents1 products
body wash/cleanser1 products
body spray1 products
shaving cream (men's)1 products

Persistence and bioaccumulation

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Concern Reference
Persistent, bioaccumulative in wildlifeCanada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List

Cancer

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Concern Reference
One or more animal studies show tumor formation at moderate dosesDow Corning Corporation 2005. Decamethylcyclopentasiloxane: A 24-month combined chronic toxicity and oncogenicity whole body vapor inhalation study in Fischer-344 rats. Dow Corning Report No. 2005-1000-54953. 4062.

Endocrine disruption

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Concern Reference
One or more animal studies show endocrine disruption at moderate dosesSiddiqui WH, Stump DG, Reynolds VL, Plotzke KP, Holson JF, Meeks RG 2007. A two- generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation. Reprod Toxicol. 23(2):216-25.

Neurotoxicity

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Concern Reference
One or more animal studies show any effects at moderate dosesJean PA, McCracken KA, Arthurton JA, Plotzke KP 2005b. Investigation of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) as dopamine D2- receptor agonists. Toxicologist 84(S-1):370.

Ecotoxicology

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Concern Reference
Suspected to be an environmental toxin and be persistent or bioaccumulativeEnvironment Canada Domestic Substance List
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
119 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Data Sources

  • EC (Environment Canada). 1994. Accelerated Reduction/Elimination of Toxics (ARET). ARET substance list of persistent, bioaccumulative and toxic chemicals.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Dow Corning Corporation 2005. Decamethylcyclopentasiloxane: A 24-month combined chronic toxicity and oncogenicity whole body vapor inhalation study in Fischer-344 rats. Dow Corning Report No. 2005-1000-54953. 4062.
  • Siddiqui WH, Stump DG, Reynolds VL, Plotzke KP, Holson JF, Meeks RG 2007. A two- generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation. Reprod Toxicol. 23(2):216-25.
  • Jean PA, McCracken KA, Arthurton JA, Plotzke KP 2005b. Investigation of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) as dopamine D2- receptor agonists. Toxicologist 84(S-1):370.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.

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