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CYCLOPENTASILOXANE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Neurotoxicity (low), Endocrine disruption (low), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), and Ecotoxicology (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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foundation722 products
lipstick508 products
concealer384 products
eye shadow175 products
eye liner167 products
moisturizer with SPF123 products
lip liner86 products
antiperspirant/deodorant80 products
blush74 products
makeup primer70 products
serums & essences64 products
beach & sport sunscreen63 products
conditioner62 products
hair treatment/serum57 products
brow liner50 products
facial moisturizer/treatment46 products
antiperspirant/deodorant (men's)43 products
moisturizer40 products
BB cream32 products
mask30 products
CC cream27 products
hair spray24 products
mascara24 products
bronzer/highlighter24 products
makeup remover21 products
lip gloss20 products
lip balm with SPF20 products
shampoo18 products
hair styling aide16 products
around-eye cream11 products
body firming lotion9 products
facial powder8 products
styling gel/lotion8 products
eye makeup remover8 products
detangler7 products
other eye makeup7 products
hand cream6 products
makeup with SPF5 products
facial cleanser4 products
body spray4 products
baby sunscreen3 products
anti-aging3 products
after shave3 products
hair color and bleaching2 products
beard care2 products
oil controller2 products
beard oil1 products
1 products
styling mousse/foam1 products
shaving cream (men's)1 products
baby oil1 products
body oil1 products
hair relaxer1 products
fragrance for men1 products
toners/astringents1 products
body wash/cleanser1 products

Persistence and bioaccumulation

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Concern Reference
Persistent, bioaccumulative in wildlifeCanada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List

Cancer

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Concern Reference
Uterine tumors in female ratsDow Corning Corporation 2005. Decamethylcyclopentasiloxane: A 24-month combined chronic toxicity and oncogenicity whole body vapor inhalation study in Fischer-344 rats. Dow Corning Report No. 2005-1000-54953. 4062.

Endocrine disruption

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Concern Reference
Increased anogenital distance observed in rats at a moderate dose.Siddiqui WH, Stump DG, Reynolds VL, Plotzke KP, Holson JF, Meeks RG 2007. A two- generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation. Reprod Toxicol. 23(2):216-25.

Neurotoxicity

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Concern Reference
Moderate dose in rate suggested dopamine D2-receptor behavior on pituitary cells.Jean PA, McCracken KA, Arthurton JA, Plotzke KP 2005b. Investigation of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) as dopamine D2- receptor agonists. Toxicologist 84(S-1):370.

Ecotoxicology

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Concern Reference
Suspected to be an environmental toxin and be persistent or bioaccumulativeEnvironment Canada Domestic Substance List
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
119 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Data Sources

  • EC (Environment Canada). 1994. Accelerated Reduction/Elimination of Toxics (ARET). ARET substance list of persistent, bioaccumulative and toxic chemicals.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Dow Corning Corporation 2005. Decamethylcyclopentasiloxane: A 24-month combined chronic toxicity and oncogenicity whole body vapor inhalation study in Fischer-344 rats. Dow Corning Report No. 2005-1000-54953. 4062.
  • Siddiqui WH, Stump DG, Reynolds VL, Plotzke KP, Holson JF, Meeks RG 2007. A two- generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation. Reprod Toxicol. 23(2):216-25.
  • Jean PA, McCracken KA, Arthurton JA, Plotzke KP 2005b. Investigation of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) as dopamine D2- receptor agonists. Toxicologist 84(S-1):370.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.

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