Menu Close Menu

Menu

CYCLOPENTASILOXANE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Neurotoxicity (low), Endocrine disruption (low), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), and Ecotoxicology (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

Expand content Collapse content
foundation613 products
lipstick348 products
concealer294 products
eye liner132 products
moisturizer with SPF123 products
eye shadow84 products
antiperspirant/deodorant78 products
lip liner71 products
beach & sport sunscreen63 products
serums & essences61 products
conditioner58 products
makeup primer56 products
hair treatment/serum47 products
facial moisturizer/treatment41 products
blush41 products
brow liner39 products
antiperspirant/deodorant (men's)39 products
moisturizer34 products
BB cream29 products
mask28 products
CC cream27 products
mascara20 products
lip balm with SPF20 products
around-eye cream19 products
bronzer/highlighter19 products
makeup remover19 products
shampoo16 products
hair spray14 products
hair styling aide12 products
body firming lotion9 products
other eye makeup7 products
hand cream7 products
eye makeup remover6 products
styling gel/lotion6 products
detangler6 products
body spray4 products
anti-aging4 products
after shave3 products
baby sunscreen3 products
lip gloss3 products
facial cleanser3 products
facial powder3 products
hair color and bleaching2 products
makeup with SPF2 products
oil controller2 products
styling mousse/foam1 products
toners/astringents1 products
body wash/cleanser1 products
hair relaxer1 products
shaving cream (men's)1 products
baby oil1 products
fragrance for men1 products
body oil1 products
beard oil1 products
beard care1 products

Persistence and bioaccumulation

Expand content Collapse content
Concern Reference
Persistent, bioaccumulative in wildlifeCanada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)

Organ system toxicity (non-reproductive)

Expand content Collapse content
Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List

Cancer

Expand content Collapse content
Concern Reference
Uterine tumors in female ratsDow Corning Corporation 2005. Decamethylcyclopentasiloxane: A 24-month combined chronic toxicity and oncogenicity whole body vapor inhalation study in Fischer-344 rats. Dow Corning Report No. 2005-1000-54953. 4062.

Endocrine disruption

Expand content Collapse content
Concern Reference
Increased anogenital distance observed in rats at a moderate dose.Siddiqui WH, Stump DG, Reynolds VL, Plotzke KP, Holson JF, Meeks RG 2007. A two- generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation. Reprod Toxicol. 23(2):216-25.

Neurotoxicity

Expand content Collapse content
Concern Reference
Moderate dose in rate suggested dopamine D2-receptor behavior on pituitary cells.Jean PA, McCracken KA, Arthurton JA, Plotzke KP 2005b. Investigation of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) as dopamine D2- receptor agonists. Toxicologist 84(S-1):370.

Ecotoxicology

Expand content Collapse content
Concern Reference
Suspected to be an environmental toxin and be persistent or bioaccumulativeEnvironment Canada Domestic Substance List
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

Expand content Collapse content
Concern Reference
119 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

Expand content Collapse content
Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Data Sources

  • EC (Environment Canada). 1994. Accelerated Reduction/Elimination of Toxics (ARET). ARET substance list of persistent, bioaccumulative and toxic chemicals.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Dow Corning Corporation 2005. Decamethylcyclopentasiloxane: A 24-month combined chronic toxicity and oncogenicity whole body vapor inhalation study in Fischer-344 rats. Dow Corning Report No. 2005-1000-54953. 4062.
  • Siddiqui WH, Stump DG, Reynolds VL, Plotzke KP, Holson JF, Meeks RG 2007. A two- generation reproductive toxicity study of decamethylcyclopentasiloxane (D5) in rats exposed by whole-body vapor inhalation. Reprod Toxicol. 23(2):216-25.
  • Jean PA, McCracken KA, Arthurton JA, Plotzke KP 2005b. Investigation of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) as dopamine D2- receptor agonists. Toxicologist 84(S-1):370.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

ABOUT EWG VERIFIED™

Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer