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CYCLOMETHICONE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption, Endocrine disruption (moderate), Persistence and bioaccumulation (high), Non-reproductive organ system toxicity (moderate), and Ecotoxicology (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW_MODERATE

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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foundation62 products
moisturizer with SPF18 products
bronzer/highlighter15 products
moisturizer14 products
serums & essences10 products
facial moisturizer/treatment10 products
lipstick10 products
eye shadow8 products
beach & sport sunscreen6 products
eye liner6 products
brow liner5 products
hair treatment/serum4 products
around-eye cream3 products
anti-aging3 products
makeup remover2 products
hair styling aide2 products
shampoo2 products
makeup primer2 products
antiperspirant/deodorant1 products
detangler1 products
styling gel/lotion1 products
styling mousse/foam1 products
mascara1 products
toners/astringents1 products
antiperspirant/deodorant (men's)1 products
facial powder1 products
body firming lotion1 products
blush1 products
beard care1 products

Enhanced skin absorption

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Concern Reference
A peer-reviewed publication disrupts hormones and interferes with ovulation in animals.Anne L Quinn, Abe Dalu, Linda S. Meeker, Paul A. Jean, Robert G. Meeks, James W. Crissman, Robert H. Gallavan & Kathleen P. Plotzke. 2007. Effects of octamethylcyclotetrasiloxane (D4) on the luteinizing hormone (LH) surge and levels of various reproductive hormones in female Sprague-Dawley rats. Reproductive toxicology (Elmsford, N.Y.) 23(4), 532-40.

Persistence and bioaccumulation

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Concern Reference
Persistent, bioaccumulative in wildlife and humans2018 ECHA Candidate List of substances of very high concern for Authorisation.
Persistent or bioaccumulative and moderate to high toxicity concern in humansEnvironment Canada Domestic Substance List
Persistent, bioaccumulative in wildlifeCanada PBTs - Accelerated Reduction/Elimination of Toxics (ARET)
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Endocrine disruption

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Concern Reference
Evidence of endocrine disrupting activity in at least one species using intact animals, high human health concern.European Union 2015. European Commission on Endocrine Disruption. Appears as: listid: EU-ENDO-691; Chemical_Name: Cyclotetrasiloxane; ; CAS: 556-67-2
This substance reduced thymus and ovarian weights in female rats at moderate doses.Danish Ministry of the Environment 2005. Siloxanes - Consumption, Toxicity and Alternatives.
Animal studies show this substance has weak estrogenic activity.California Environmental Protection Agency, Office of Environmental Health Hazard Assessment 2008. Cyclosiloxanes. Materials for the December 4-5, 2008 Meeting of the California Environmental Contaminant Biomonitoring Program (CECBP) Scientific Guidance Panel (SGP).

Organ system toxicity (non-reproductive)

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Concern Reference
Deemed a high human health priority and was flagged by CEPA for further attention. The chemical is suspected to be a developmental and reproductive toxin, persistent, bioaccumulate and toxic to aquatic organisms.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-02988; Chemical_Name: Cyclotetrasiloxane, octamethyl-; ; CAS: 556-67-2
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Classified as medium human health priorityEnvironment Canada Domestic Substance List
Limited evidence shows this substance is toxic to the liver.California Environmental Protection Agency, Office of Environmental Health Hazard Assessment 2008. Cyclosiloxanes. Materials for the December 4-5, 2008 Meeting of the California Environmental Contaminant Biomonitoring Program (CECBP) Scientific Guidance Panel (SGP).

Developmental/reproductive toxicity

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Concern Reference
Limited evidence of reproductive toxicityEU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 014-018-00-1; Chemical_Name: octamethylcyclotetrasiloxane; ; CAS: 556-67-2
Read-across data predicts this substance may be a reproductive toxicant.Krestine Greve, Elsa Nielsen & Ole Ladefoged 2008. Toxic effects of siloxanes: Group evaluation of D3, D4, D5, D6 and HMDS in order to set a health based quality criterion in ambient air. Toxicology Letters 180, Supplement, Pages S67.
Animals studies show this substance has adverse effects on reproductive health and function.California Environmental Protection Agency, Office of Environmental Health Hazard Assessment 2008. Cyclosiloxanes. Materials for the December 4-5, 2008 Meeting of the California Environmental Contaminant Biomonitoring Program (CECBP) Scientific Guidance Panel (SGP).

Ecotoxicology

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Concern Reference
Deemed a high human health priority and was flagged by CEPA for further attention. The chemical is suspected to be a developmental and reproductive toxin, persistent, bioaccumulate and toxic to aquatic organisms.Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-02988; Chemical_Name: Cyclotetrasiloxane, octamethyl-; ; CAS: 556-67-2
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
103 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Data Sources

  • Anne L Quinn, Abe Dalu, Linda S. Meeker, Paul A. Jean, Robert G. Meeks, James W. Crissman, Robert H. Gallavan & Kathleen P. Plotzke. 2007. Effects of octamethylcyclotetrasiloxane (D4) on the luteinizing hormone (LH) surge and levels of various reproductive hormones in female Sprague-Dawley rats. Reproductive toxicology (Elmsford, N.Y.) 23(4), 532-40.
  • 2018 ECHA Candidate List of substances of very high concern for Authorisation.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • EC (Environment Canada). 1994. Accelerated Reduction/Elimination of Toxics (ARET). ARET substance list of persistent, bioaccumulative and toxic chemicals.
  • European Union 2015. European Commission on Endocrine Disruption. Appears as: listid: EU-ENDO-691; Chemical_Name: Cyclotetrasiloxane; ; CAS: 556-67-2
  • Danish Ministry of the Environment 2005. Siloxanes - Consumption, Toxicity and Alternatives.
  • California Environmental Protection Agency, Office of Environmental Health Hazard Assessment 2008. Cyclosiloxanes. Materials for the December 4-5, 2008 Meeting of the California Environmental Contaminant Biomonitoring Program (CECBP) Scientific Guidance Panel (SGP).
  • Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-02988; Chemical_Name: Cyclotetrasiloxane, octamethyl-; ; CAS: 556-67-2
  • EU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 014-018-00-1; Chemical_Name: octamethylcyclotetrasiloxane; ; CAS: 556-67-2
  • Krestine Greve, Elsa Nielsen & Ole Ladefoged 2008. Toxic effects of siloxanes: Group evaluation of D3, D4, D5, D6 and HMDS in order to set a health based quality criterion in ambient air. Toxicology Letters 180, Supplement, Pages S67.
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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