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COUMARIN
Score:
Data: Fair
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| fragrance for women | 75 products |
| moisturizer | 58 products |
| shampoo | 54 products |
| body wash/cleanser | 45 products |
| conditioner | 35 products |
| foundation | 31 products |
| fragrance for men | 30 products |
| hair treatment/serum | 29 products |
| mask | 17 products |
| moisturizer with SPF | 16 products |
| body firming lotion | 15 products |
| hair styling aide | 15 products |
| facial moisturizer/treatment | 14 products |
| hand cream | 13 products |
| bronzer/highlighter | 13 products |
| bath oil/salts/soak | 13 products |
| serums & essences | 12 products |
| eye shadow | 12 products |
| body spray | 11 products |
| styling gel/lotion | 11 products |
| lipstick | 10 products |
| facial cleanser | 10 products |
| hair spray | 10 products |
| antiperspirant/deodorant | 9 products |
| liquid hand soap | 9 products |
| sunless tanning | 8 products |
| detangler | 7 products |
| body oil | 5 products |
| antiperspirant/deodorant (men's) | 5 products |
| bar soap | 5 products |
| styling mousse/foam | 5 products |
| beach & sport sunscreen | 4 products |
| exfoliant/scrub | 3 products |
| after shave | 3 products |
| blush | 3 products |
| beard oil | 3 products |
| toners/astringents | 3 products |
| shaving cream | 3 products |
| hair color and bleaching | 2 products |
| makeup remover | 2 products |
| lip balm | 2 products |
| baby soap | 2 products |
| baby lotion | 2 products |
| diaper cream | 2 products |
| makeup primer | 2 products |
| after sun product | 2 products |
| BB cream | 2 products |
| baby shampoo | 2 products |
| anti-aging | 1 products |
| bubble bath | 1 products |
| makeup with SPF | 1 products |
| vapor rubs | 1 products |
| beard care | 1 products |
| hair relaxer | 1 products |
| around-eye cream | 1 products |
| baby oil | 1 products |
| Facial Sun Care | 1 products |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| Known human immune system toxicant or allergen | SCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999. |
| Limited evidence of [[system]] toxicity or allergies | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Coumarin; 2H-chromen-2-one; (2H)-1-Benzopyran-2-one; -; - chromen-2-one; 1,2-benzopyran-2-one; 1,2-benzopyrone; 1-Benzopyran-2-one; 2H Chromen-2-one; 2H-1-Benzopyran-2-on; 2H-1-Benzopyran-2-one; 2H-Chromen-2-one; Chromen-2-one; COUMARIN; Coumarin; 2H-; cas_numbers: 91-64-5 |
Cancer
| Concern | Reference |
|---|---|
| Cancer - limited evidence | Carcinogenic Potency Database http://potency.berkeley.edu/app14.html Environmental Defense reviewed this compilation of results on carcinogenicity in rats and mice covering 1298 chemicals and added any chemical with positive results in at least two species by a relevant route of exposure to its list of suspect carcinogens. |
| Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gaps | World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 77;2000 |
Miscellaneous
| Concern | Reference |
|---|---|
| Prohibited for use in food | FDA Food Additive Status |
Data gaps
| Concern | Reference |
|---|---|
| 8313 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
| Concern | Reference |
|---|---|
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Informational
| Concern | Reference |
|---|---|
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - The substance was formerly approved as a food additive but is now banned; there may be some toxicology data available. | FDA Everything Added to Food |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Not suspected to be persistent | Environment Canada Domestic Substance List |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Use restrictions
| Concern | Reference |
|---|---|
| Restricted in cosmetics - labeling requirement for allergens | CosIng |
Data Sources
- SCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999.
- European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Coumarin; 2H-chromen-2-one; (2H)-1-Benzopyran-2-one; -; - chromen-2-one; 1,2-benzopyran-2-one; 1,2-benzopyrone; 1-Benzopyran-2-one; 2H Chromen-2-one; 2H-1-Benzopyran-2-on; 2H-1-Benzopyran-2-one; 2H-Chromen-2-one; Chromen-2-one; COUMARIN; Coumarin; 2H-; cas_numbers: 91-64-5
- Carcinogenic Potency Database http://potency.berkeley.edu/app14.html Environmental Defense reviewed this compilation of results on carcinogenicity in rats and mice covering 1298 chemicals and added any chemical with positive results in at least two species by a relevant route of exposure to its list of suspect carcinogens.
- World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 77;2000
- FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
- European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
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