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COUMARIN

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is HIGH

Products with this Ingredient

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fragrance for women75 products
moisturizer58 products
shampoo54 products
body wash/cleanser45 products
conditioner35 products
foundation31 products
fragrance for men30 products
hair treatment/serum29 products
mask17 products
moisturizer with SPF16 products
body firming lotion15 products
hair styling aide15 products
facial moisturizer/treatment14 products
hand cream13 products
bronzer/highlighter13 products
bath oil/salts/soak13 products
serums & essences12 products
eye shadow12 products
body spray11 products
styling gel/lotion11 products
lipstick10 products
facial cleanser10 products
hair spray10 products
antiperspirant/deodorant9 products
liquid hand soap9 products
sunless tanning8 products
detangler7 products
body oil5 products
antiperspirant/deodorant (men's)5 products
bar soap5 products
styling mousse/foam5 products
beach & sport sunscreen4 products
exfoliant/scrub3 products
after shave3 products
blush3 products
beard oil3 products
toners/astringents3 products
shaving cream3 products
hair color and bleaching2 products
makeup remover2 products
lip balm2 products
baby soap2 products
baby lotion2 products
diaper cream2 products
makeup primer2 products
after sun product2 products
BB cream2 products
baby shampoo2 products
anti-aging1 products
bubble bath1 products
makeup with SPF1 products
vapor rubs1 products
beard care1 products
hair relaxer1 products
around-eye cream1 products
baby oil1 products
Facial Sun Care1 products

Allergies/immunotoxicity

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Concern Reference
Known human immune system toxicant or allergenSCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999.
Limited evidence of [[system]] toxicity or allergiesEuropean Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Coumarin; 2H-chromen-2-one; (2H)-1-Benzopyran-2-one; -; - chromen-2-one; 1,2-benzopyran-2-one; 1,2-benzopyrone; 1-Benzopyran-2-one; 2H Chromen-2-one; 2H-1-Benzopyran-2-on; 2H-1-Benzopyran-2-one; 2H-Chromen-2-one; Chromen-2-one; COUMARIN; Coumarin; 2H-; cas_numbers: 91-64-5

Cancer

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Concern Reference
Cancer - limited evidenceCarcinogenic Potency Database http://potency.berkeley.edu/app14.html Environmental Defense reviewed this compilation of results on carcinogenicity in rats and mice covering 1298 chemicals and added any chemical with positive results in at least two species by a relevant route of exposure to its list of suspect carcinogens.
Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gapsWorld Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 77;2000

Miscellaneous

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Concern Reference
Prohibited for use in foodFDA Food Additive Status

Data gaps

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Concern Reference
8313 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - The substance was formerly approved as a food additive but is now banned; there may be some toxicology data available.FDA Everything Added to Food

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Use restrictions

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Concern Reference
Restricted in cosmetics - labeling requirement for allergensCosIng

Data Sources

  • SCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999.
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Coumarin; 2H-chromen-2-one; (2H)-1-Benzopyran-2-one; -; - chromen-2-one; 1,2-benzopyran-2-one; 1,2-benzopyrone; 1-Benzopyran-2-one; 2H Chromen-2-one; 2H-1-Benzopyran-2-on; 2H-1-Benzopyran-2-one; 2H-Chromen-2-one; Chromen-2-one; COUMARIN; Coumarin; 2H-; cas_numbers: 91-64-5
  • Carcinogenic Potency Database http://potency.berkeley.edu/app14.html Environmental Defense reviewed this compilation of results on carcinogenicity in rats and mice covering 1298 chemicals and added any chemical with positive results in at least two species by a relevant route of exposure to its list of suspect carcinogens.
  • World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 77;2000
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
  • European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .

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