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CITRUS AURANTIUM DULCIS (SWEET ORANGE) OIL

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), Ecotoxicology (low), and Irritation (skin, eyes, or lungs) (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is HIGH

Products with this Ingredient

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moisturizer106 products
facial moisturizer/treatment88 products
shampoo80 products
body wash/cleanser71 products
beach & sport sunscreen66 products
moisturizer with SPF56 products
facial cleanser55 products
exfoliant/scrub51 products
liquid hand soap49 products
conditioner43 products
lip balm38 products
serums & essences37 products
bar soap37 products
mask28 products
body oil26 products
bath oil/salts/soak25 products
antiperspirant/deodorant22 products
foundation21 products
hair treatment/serum18 products
hand cream15 products
hand sanitizer13 products
toners/astringents11 products
makeup remover11 products
lip gloss11 products
baby soap10 products
fragrance for women10 products
bubble bath10 products
shaving cream10 products
anti-aging9 products
baby shampoo9 products
body spray8 products
hair styling aide8 products
styling gel/lotion7 products
baby lotion6 products
toothpaste6 products
beard oil6 products
lip balm with SPF6 products
shaving cream (men's)5 products
baby oil5 products
baby bubble bath5 products
detangler5 products
BB cream5 products
lipstick5 products
body firming lotion5 products
makeup primer5 products
around-eye cream4 products
CC cream4 products
hair spray4 products
antiperspirant/deodorant (men's)4 products
foot cleansing3 products
fragrance for men3 products
eye makeup remover2 products
baby sunscreen2 products
sunless tanning2 products
after sun product2 products
cuticle treatment2 products
foot odor control2 products
lip plumper1 products
body powder1 products
after shave1 products
nail treatment1 products
mouthwash1 products
baby powder1 products
vapor rubs1 products
Facial Sun Care1 products
foot moisturizer1 products
baby wipes1 products
facial powder1 products
makeup with SPF1 products

Allergies/immunotoxicity

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Concern Reference
Known human skin toxicant or allergenOpinion on Frangrance allergens in cosmetics (2011), EU Cosmetics Directive
Possible human any toxicant or allergenEuropean Union 2015. Banned and Restricted Fragrances. Appears as: listid: EUFRAG-046; Chemical_Name: Limonene; Synonyms: d-Limonene;
Human any toxicant or allergen - strong evidenceSafer Chemical Ingredients List (2018-02-28), Environmental Protection Agency (EPA)
Limited evidence of any toxicity or allergiesEU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5
Limited evidence of any toxicity or allergiesUS. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0695-1; Chemical_Name: d-Limonene; ; CAS: 5989-27-5
Limited evidence of any toxicity or allergiesEuropean Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Orange, sweet, ext.; (2E,6E)-2,6-dimethyl-10-methylidenedodeca-2,6,11-trienal; (2E,6E,9E)-2,6,10-trimethyldodeca-2,6,9,11-tetraenal; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; 3,7-dimethylocta-1,6-dien-3-ol; 7-methyl-3-methylideneocta-1,6-diene; ; cas_numbers: 8028-48-6, 68647-72-3

Irritation (skin, eyes, or lungs)

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Concern Reference
Classified as any irritantEU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5
Human any irritant - moderate evidenceInternational Fragrance Association (IFRA) 2015. IFRA Codes & Standards. Appears as: listid: IFRA-029-01; Chemical_Name: Bitter Orange Peel Oil Expressed; Synonyms: Orange Peel Oil, Bitter (Citrus aurantium L. subsp amara L.)Bitter orange oil (Citrus aurantium L. subsp. amara L.)Citrus aurantium peel oil Curacao peel oil (Citrus aurantium L.) Daidai peel oil (Citrus aurantium L.); CAS: 72968-50-4; Classification: Restricted
Limited evidence of any irritationEuropean Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Orange, sweet, ext.; (2E,6E)-2,6-dimethyl-10-methylidenedodeca-2,6,11-trienal; (2E,6E,9E)-2,6,10-trimethyldodeca-2,6,9,11-tetraenal; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; 3,7-dimethylocta-1,6-dien-3-ol; 7-methyl-3-methylideneocta-1,6-diene; ; cas_numbers: 8028-48-6, 68647-72-3

Persistence and bioaccumulation

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Concern Reference
Persistent, bioaccumulative in wildlifeOSPAR Comission 2015. OSPAR PBTs - Substances of Possible Concern. Appears as: listid: PBT-OSPAR-249; Chemical_Name: (4R)-CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-; Synonyms: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-; CAS: 5989-27-5
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Classified as medium human health priorityEnvironment Canada Domestic Substance List
Classified as toxic or harmful.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Orange, sweet, ext.; (2E,6E)-2,6-dimethyl-10-methylidenedodeca-2,6,11-trienal; (2E,6E,9E)-2,6,10-trimethyldodeca-2,6,9,11-tetraenal; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; 3,7-dimethylocta-1,6-dien-3-ol; 7-methyl-3-methylideneocta-1,6-diene; ; cas_numbers: 8028-48-6, 68647-72-3
Classified as not expected to be potentially toxic or harmfulEnvironment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5

Developmental/reproductive toxicity

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Concern Reference
One or more animal studies show any effects at high doses1977 Studies on d-limonene as a gallstone solubilizer (VII) Effects on development of mouse fetuses and offsprings. Oyo Yakuri 13(6), 863-873.

Ecotoxicology

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Concern Reference
Wildlife and environmental toxicityEU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List
Wildlife and environmental toxicityEuropean Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Orange, sweet, ext.; (2E,6E)-2,6-dimethyl-10-methylidenedodeca-2,6,11-trienal; (2E,6E,9E)-2,6,10-trimethyldodeca-2,6,9,11-tetraenal; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; 3,7-dimethylocta-1,6-dien-3-ol; 7-methyl-3-methylideneocta-1,6-diene; ; cas_numbers: 8028-48-6, 68647-72-3

Data gaps

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Concern Reference
Insufficient data to determine safetyCosmetic Ingredient Review (CIR) 2017. CIR Assessments. Appears as: ; Chemical_Name: Citrus Aurantium Dulcis (Orange) Oil; ; ; Classification: QQQ03;
171 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Miscellaneous

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Concern Reference
Occupational hazards related to handlingEU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5

Cancer

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Concern Reference
Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gapsIARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-653; Chemical_Name: d-Limonene; ; CAS: 5989-27-5

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Use restrictions

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Concern Reference
Restricted in cosmetics - labeling requirement for allergensEU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-27937; Chemical_Name: d-Limonene (CAS No 5989-27-5); ; CAS: 5989-27-5

Data Sources

  • Opinion on Frangrance allergens in cosmetics (2011), EU Cosmetics Directive
  • European Union 2015. Banned and Restricted Fragrances. Appears as: listid: EUFRAG-046; Chemical_Name: Limonene; Synonyms: d-Limonene;
  • Safer Chemical Ingredients List (2018-02-28), Environmental Protection Agency (EPA)
  • EU GHS Hazard Labeling Codes 2015. Classification & Labelling (Skin Deep®). Appears as: listid: 601-029-00-7-61; Chemical_Name: DIPENTENE; Synonyms: limonene; [1] ; (R)-p-mentha-1,8-diene; ; d-limonene; [2] ; (S)-p-mentha-1,8-diene; ; l-limonene; [3] ; trans-1-methyl-4-(1-methylvinyl)cyclohexene; [4] ; (±)-1-methyl-4-(1-methylvinyl)cyclohexene [5]; CAS: 5989-27-5
  • US. National Library of Medicine,. 2015. Haz-Map®. Appears as: listid: HMAP-0695-1; Chemical_Name: d-Limonene; ; CAS: 5989-27-5
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Orange, sweet, ext.; (2E,6E)-2,6-dimethyl-10-methylidenedodeca-2,6,11-trienal; (2E,6E,9E)-2,6,10-trimethyldodeca-2,6,9,11-tetraenal; (4R)-1-methyl-4-(prop-1-en-2-yl)cyclohex-1-ene; 3,7-dimethylocta-1,6-dien-3-ol; 7-methyl-3-methylideneocta-1,6-diene; ; cas_numbers: 8028-48-6, 68647-72-3
  • International Fragrance Association (IFRA) 2015. IFRA Codes & Standards. Appears as: listid: IFRA-029-01; Chemical_Name: Bitter Orange Peel Oil Expressed; Synonyms: Orange Peel Oil, Bitter (Citrus aurantium L. subsp amara L.)Bitter orange oil (Citrus aurantium L. subsp. amara L.)Citrus aurantium peel oil Curacao peel oil (Citrus aurantium L.) Daidai peel oil (Citrus aurantium L.); CAS: 72968-50-4; Classification: Restricted
  • OSPAR Comission 2015. OSPAR PBTs - Substances of Possible Concern. Appears as: listid: PBT-OSPAR-249; Chemical_Name: (4R)-CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-; Synonyms: CYCLOHEXENE, 1-METHYL-4-(1-METHYLETHENYL)-, (4R)-; CAS: 5989-27-5
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Environment Canada 2015. Domestic Substance List. Appears as: listid: ECDSL-05949; Chemical_Name: Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (R)-; ; CAS: 5989-27-5
  • 1977 Studies on d-limonene as a gallstone solubilizer (VII) Effects on development of mouse fetuses and offsprings. Oyo Yakuri 13(6), 863-873.
  • Cosmetic Ingredient Review (CIR) 2017. CIR Assessments. Appears as: ; Chemical_Name: Citrus Aurantium Dulcis (Orange) Oil; ; ; Classification: QQQ03;
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • IARC 2015. IRAC Carcinogens (Skin Deep®). Appears as: listid: IARC-653; Chemical_Name: d-Limonene; ; CAS: 5989-27-5
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
  • EU Cosmetics Directive 2015. CosIng. Appears as: listid: COSING-27937; Chemical_Name: d-Limonene (CAS No 5989-27-5); ; CAS: 5989-27-5

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EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

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