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CHLORPHENESIN
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (moderate), Non-reproductive organ system toxicity (low), and Irritation (skin, eyes, or lungs) (moderate)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| foundation | 150 products |
| mask | 120 products |
| beach & sport sunscreen | 96 products |
| moisturizer with SPF | 85 products |
| facial moisturizer/treatment | 69 products |
| eye shadow | 63 products |
| concealer | 55 products |
| serums & essences | 54 products |
| moisturizer | 50 products |
| bronzer/highlighter | 38 products |
| blush | 35 products |
| body firming lotion | 26 products |
| around-eye cream | 25 products |
| makeup primer | 24 products |
| shampoo | 20 products |
| facial cleanser | 18 products |
| facial powder | 17 products |
| BB cream | 16 products |
| mascara | 14 products |
| conditioner | 14 products |
| eye liner | 12 products |
| hair styling aide | 12 products |
| toners/astringents | 10 products |
| body wash/cleanser | 10 products |
| exfoliant/scrub | 9 products |
| setting powder/spray | 9 products |
| hair treatment/serum | 9 products |
| foot moisturizer | 7 products |
| anti-aging | 7 products |
| styling gel/lotion | 7 products |
| hand cream | 6 products |
| baby sunscreen | 6 products |
| brow liner | 5 products |
| after shave | 4 products |
| CC cream | 4 products |
| bath oil/salts/soak | 4 products |
| sunless tanning | 3 products |
| makeup remover | 3 products |
| bubble bath | 3 products |
| bar soap | 2 products |
| shaving cream (men's) | 2 products |
| hair spray | 2 products |
| detangler | 2 products |
| liquid hand soap | 1 products |
| other eye makeup | 1 products |
| body spray | 1 products |
| styling mousse/foam | 1 products |
| glitter | 1 products |
| after sun product | 1 products |
| baby soap | 1 products |
| beard cleanser | 1 products |
| shaving cream | 1 products |
| oil controller | 1 products |
| skin fading/lightener | 1 products |
| hair color and bleaching | 1 products |
| 1 products | |
| lip plumper | 1 products |
| baby shampoo | 1 products |
Use restrictions
| Concern | Reference |
|---|---|
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit) | Japan's Standards for Cosmetics |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| Allergic dermatitis reported in multiple human case studies. | Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01; |
| This substance is an immunosuppressant, according to animal and in vitro testing. | Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01; |
Irritation (skin, eyes, or lungs)
| Concern | Reference |
|---|---|
| Skin irritation reported at low concentrations in human patch testing. | Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01; |
| Classified as a weak eye irritant. | Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01; |
| REACH registration: this substance causes skin irritation. | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0 |
| CLP notifications: this substance may cause respiratory irritation. | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0 |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| LP notification: this substance is harmful if swallowed and is harmful if inhaled. | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0 |
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Data gaps
| Concern | Reference |
|---|---|
| 114 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
| Concern | Reference |
|---|---|
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Not suspected to be persistent | Environment Canada Domestic Substance List |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
- Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
- Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;
- European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
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