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CHLORPHENESIN

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (moderate), Non-reproductive organ system toxicity (low), and Irritation (skin, eyes, or lungs) (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

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foundation145 products
mask108 products
beach & sport sunscreen86 products
moisturizer with SPF75 products
serums & essences44 products
concealer41 products
facial moisturizer/treatment40 products
moisturizer36 products
blush34 products
eye shadow33 products
bronzer/highlighter24 products
around-eye cream17 products
facial powder16 products
BB cream14 products
facial cleanser13 products
mascara11 products
makeup primer10 products
shampoo10 products
body wash/cleanser9 products
body firming lotion9 products
eye liner8 products
conditioner7 products
hair styling aide7 products
styling gel/lotion6 products
exfoliant/scrub5 products
brow liner5 products
foot moisturizer5 products
makeup remover4 products
hand cream4 products
anti-aging4 products
toners/astringents4 products
baby sunscreen4 products
CC cream4 products
bath oil/salts/soak2 products
after shave2 products
hair treatment/serum2 products
sunless tanning2 products
hair spray2 products
skin fading/lightener1 products
other eye makeup1 products
shaving cream (men's)1 products
body spray1 products
liquid hand soap1 products
glitter1 products
shaving cream1 products
lip plumper1 products

Use restrictions

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Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)Japan's Standards for Cosmetics

Allergies/immunotoxicity

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Concern Reference
Allergic dermatitis reported in multiple human case studies.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;
This substance is an immunosuppressant, according to animal and in vitro testing.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;

Irritation (skin, eyes, or lungs)

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Concern Reference
Skin irritation reported at low concentrations in human patch testing.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;
Classified as a weak eye irritant.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;
REACH registration: this substance causes skin irritation. European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0
CLP notifications: this substance may cause respiratory irritation.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0

Organ system toxicity (non-reproductive)

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Concern Reference
LP notification: this substance is harmful if swallowed and is harmful if inhaled.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
114 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
  • Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About this Ingredient's Score Range

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