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CHLORPHENESIN

image source: PubChem

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Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms

  • Use restrictions (moderate), Non-reproductive organ system toxicity (low), and Irritation (skin, eyes, or lungs) (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

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mask201 products
foundation190 products
recreational sunscreen133 products
concealer132 products
moisturizer110 products
facial moisturizer/treatment106 products
daily use with SPF85 products
eye shadow78 products
body firming lotion53 products
serums & essences52 products
bronzer/highlighter45 products
shampoo42 products
blush40 products
around-eye cream40 products
facial cleanser35 products
makeup primer28 products
hand cream28 products
exfoliant/scrub28 products
conditioner27 products
hair treatment/serum24 products
BB cream23 products
body wash/cleanser23 products
facial powder20 products
mascara20 products
hair styling aide17 products
eye liner16 products
setting powder/spray14 products
CC cream14 products
baby sunscreen14 products
toners/astringents12 products
foot moisturizer10 products
makeup remover10 products
anti-aging10 products
styling gel/lotion8 products
bubble bath8 products
liquid hand soap7 products
brow liner5 products
detangler4 products
bath oil/salts/soak4 products
after shave4 products
hair spray4 products
foot cleansing4 products
bar soap3 products
hair-loss treatment3 products
sunless tanning3 products
body spray2 products
foot odor control2 products
antiperspirant/deodorant2 products
shaving cream (men's)2 products
after sun product2 products
baby shampoo1 products
baby soap1 products
lip plumper1 products
damaged skin treatment1 products
beard cleanser1 products
lipstick1 products
glitter1 products
hair color and bleaching1 products
styling mousse/foam1 products
eyelash glue1 products
skin fading/lightener1 products
oil controller1 products
1 products
shaving cream1 products

Use restrictions

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Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)Japan's Standards for Cosmetics

Allergies/immunotoxicity

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Concern Reference
Allergic dermatitis reported in multiple human case studies.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;
This substance is an immunosuppressant, according to animal and in vitro testing.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;

Irritation (skin, eyes, or lungs)

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Concern Reference
Skin irritation reported at low concentrations in human patch testing.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;
Classified as a weak eye irritant.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;
REACH registration: this substance causes skin irritation. European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0
CLP notifications: this substance may cause respiratory irritation.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0

Organ system toxicity (non-reproductive)

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Concern Reference
LP notification: this substance is harmful if swallowed and is harmful if inhaled.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
114 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
  • Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

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