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CHLORPHENESIN

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (moderate), Non-reproductive organ system toxicity (low), and Irritation (skin, eyes, or lungs) (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

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foundation150 products
mask120 products
beach & sport sunscreen96 products
moisturizer with SPF85 products
facial moisturizer/treatment69 products
eye shadow63 products
concealer55 products
serums & essences54 products
moisturizer50 products
bronzer/highlighter38 products
blush35 products
body firming lotion26 products
around-eye cream25 products
makeup primer24 products
shampoo20 products
facial cleanser18 products
facial powder17 products
BB cream16 products
mascara14 products
conditioner14 products
eye liner12 products
hair styling aide12 products
toners/astringents10 products
body wash/cleanser10 products
exfoliant/scrub9 products
setting powder/spray9 products
hair treatment/serum9 products
foot moisturizer7 products
anti-aging7 products
styling gel/lotion7 products
hand cream6 products
baby sunscreen6 products
brow liner5 products
after shave4 products
CC cream4 products
bath oil/salts/soak4 products
sunless tanning3 products
makeup remover3 products
bubble bath3 products
bar soap2 products
shaving cream (men's)2 products
hair spray2 products
detangler2 products
liquid hand soap1 products
other eye makeup1 products
body spray1 products
styling mousse/foam1 products
glitter1 products
after sun product1 products
baby soap1 products
beard cleanser1 products
shaving cream1 products
oil controller1 products
skin fading/lightener1 products
hair color and bleaching1 products
1 products
lip plumper1 products
baby shampoo1 products

Use restrictions

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Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit)Japan's Standards for Cosmetics

Allergies/immunotoxicity

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Concern Reference
Allergic dermatitis reported in multiple human case studies.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;
This substance is an immunosuppressant, according to animal and in vitro testing.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;

Irritation (skin, eyes, or lungs)

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Concern Reference
Skin irritation reported at low concentrations in human patch testing.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;
Classified as a weak eye irritant.Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;
REACH registration: this substance causes skin irritation. European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0
CLP notifications: this substance may cause respiratory irritation.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0

Organ system toxicity (non-reproductive)

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Concern Reference
LP notification: this substance is harmful if swallowed and is harmful if inhaled.European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
114 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
  • Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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