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CHLORPHENESIN
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (moderate), Non-reproductive organ system toxicity (low), and Irritation (skin, eyes, or lungs) (moderate)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| foundation | 149 products |
| mask | 113 products |
| beach & sport sunscreen | 86 products |
| moisturizer with SPF | 76 products |
| eye shadow | 56 products |
| concealer | 53 products |
| serums & essences | 47 products |
| facial moisturizer/treatment | 46 products |
| moisturizer | 39 products |
| blush | 35 products |
| bronzer/highlighter | 35 products |
| around-eye cream | 21 products |
| makeup primer | 17 products |
| facial powder | 17 products |
| facial cleanser | 14 products |
| BB cream | 14 products |
| eye liner | 12 products |
| shampoo | 11 products |
| mascara | 10 products |
| body wash/cleanser | 10 products |
| hair styling aide | 9 products |
| body firming lotion | 9 products |
| toners/astringents | 8 products |
| conditioner | 7 products |
| foot moisturizer | 7 products |
| exfoliant/scrub | 6 products |
| styling gel/lotion | 6 products |
| hand cream | 5 products |
| brow liner | 5 products |
| hair treatment/serum | 4 products |
| baby sunscreen | 4 products |
| makeup remover | 4 products |
| anti-aging | 4 products |
| CC cream | 4 products |
| sunless tanning | 2 products |
| hair spray | 2 products |
| after shave | 2 products |
| bath oil/salts/soak | 2 products |
| bubble bath | 2 products |
| shaving cream | 1 products |
| skin fading/lightener | 1 products |
| bar soap | 1 products |
| shaving cream (men's) | 1 products |
| liquid hand soap | 1 products |
| other eye makeup | 1 products |
| body spray | 1 products |
| glitter | 1 products |
| lip plumper | 1 products |
Use restrictions
| Concern | Reference |
|---|---|
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit) | Japan's Standards for Cosmetics |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| Allergic dermatitis reported in multiple human case studies. | Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01; |
| This substance is an immunosuppressant, according to animal and in vitro testing. | Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01; |
Irritation (skin, eyes, or lungs)
| Concern | Reference |
|---|---|
| Skin irritation reported at low concentrations in human patch testing. | Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01; |
| Classified as a weak eye irritant. | Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01; |
| REACH registration: this substance causes skin irritation. | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0 |
| CLP notifications: this substance may cause respiratory irritation. | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0 |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| LP notification: this substance is harmful if swallowed and is harmful if inhaled. | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0 |
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Data gaps
| Concern | Reference |
|---|---|
| 114 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
| Concern | Reference |
|---|---|
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Not suspected to be persistent | Environment Canada Domestic Substance List |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
- Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
- Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;
- European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
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EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
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