CHLORPHENESIN
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (moderate), Non-reproductive organ system toxicity (low), and Irritation (skin, eyes, or lungs) (moderate)
Cancer 

Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity 

Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity 

Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
foundation | 150 products |
mask | 120 products |
beach & sport sunscreen | 96 products |
moisturizer with SPF | 85 products |
facial moisturizer/treatment | 69 products |
eye shadow | 63 products |
concealer | 55 products |
serums & essences | 54 products |
moisturizer | 50 products |
bronzer/highlighter | 38 products |
blush | 35 products |
body firming lotion | 26 products |
around-eye cream | 25 products |
makeup primer | 24 products |
shampoo | 20 products |
facial cleanser | 18 products |
facial powder | 17 products |
BB cream | 16 products |
mascara | 14 products |
conditioner | 14 products |
eye liner | 12 products |
hair styling aide | 12 products |
toners/astringents | 10 products |
body wash/cleanser | 10 products |
exfoliant/scrub | 9 products |
setting powder/spray | 9 products |
hair treatment/serum | 9 products |
foot moisturizer | 7 products |
anti-aging | 7 products |
styling gel/lotion | 7 products |
hand cream | 6 products |
baby sunscreen | 6 products |
brow liner | 5 products |
after shave | 4 products |
CC cream | 4 products |
bath oil/salts/soak | 4 products |
sunless tanning | 3 products |
makeup remover | 3 products |
bubble bath | 3 products |
bar soap | 2 products |
shaving cream (men's) | 2 products |
hair spray | 2 products |
detangler | 2 products |
liquid hand soap | 1 products |
other eye makeup | 1 products |
body spray | 1 products |
styling mousse/foam | 1 products |
glitter | 1 products |
after sun product | 1 products |
baby soap | 1 products |
beard cleanser | 1 products |
shaving cream | 1 products |
oil controller | 1 products |
skin fading/lightener | 1 products |
hair color and bleaching | 1 products |
1 products | |
lip plumper | 1 products |
baby shampoo | 1 products |
Use restrictions
Concern | Reference |
---|---|
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in some types of cosmetics (concentration limit) | Japan's Standards for Cosmetics |
Allergies/immunotoxicity
Concern | Reference |
---|---|
Allergic dermatitis reported in multiple human case studies. | Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01; |
This substance is an immunosuppressant, according to animal and in vitro testing. | Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01; |
Irritation (skin, eyes, or lungs)
Concern | Reference |
---|---|
Skin irritation reported at low concentrations in human patch testing. | Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01; |
Classified as a weak eye irritant. | Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01; |
REACH registration: this substance causes skin irritation. | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0 |
CLP notifications: this substance may cause respiratory irritation. | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0 |
Organ system toxicity (non-reproductive)
Concern | Reference |
---|---|
LP notification: this substance is harmful if swallowed and is harmful if inhaled. | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0 |
Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Data gaps
Concern | Reference |
---|---|
114 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
Concern | Reference |
---|---|
Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Persistence and bioaccumulation
Concern | Reference |
---|---|
Not suspected to be persistent | Environment Canada Domestic Substance List |
Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
- Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
- Cosmetic Ingredient Review (CIR) 2020. CIR Assessments. Appears as: ; Chemical_Name: CHLORPHENESIN; ; CAS: 104-29-0; Classification: QQQ01;
- European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Chlorphenesin; 3-(4-chlorophenoxy)propane-1,2-diol; -; 1,2-propanediol, 3-(4-chlorophenoxy)-; 3-(4-Chlorophenoxy)-1,2-propanediol; 3-(4-Chlorophenoxy)-1,2-propanediole; 3-(4-chlorophenoxy)propane-1,2-diol; Chlorphenesin; Chlorphenesin; Cosvat; DEKABEN; cas_numbers: 104-29-0
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
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EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
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