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CHLOROXYLENOL

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (low), Irritation (skin, eyes, or lungs) (high), and Occupational hazards (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

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foot moisturizer1 products

Irritation (skin, eyes, or lungs)

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Concern Reference
Classified as irritantCPS&Q - Classification & Labelling
Human any irritant - strong evidenceJACT 4(5):147-69, 1985 confirmed 02/04 IJT 25(S2), 2006

Occupational hazards

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Concern Reference
Allowed workplace exposures restricted to low dosesCPS&Q - Classification & Labelling

Persistence and bioaccumulation

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Concern Reference
Persistent, bioaccumulative in wildlifeEmerging PBTs from peer-reviewed literature
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Allergies/immunotoxicity

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Concern Reference
Limited evidence of immune system toxicity or allergiesCPS&Q - Classification & Labelling
Limited evidence of immune system toxicity or allergiesA Relational Database of Hazardous Chemicals and Occupational Diseases Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html, Nordic Council of Ministers (Nordic Allergy Project). Kriteriedokumenter fra nordisk allergiprojekt - vurdering af 50 kemiske stoffers evne til at forarsage allergi, en litteraturgennemgang. Nord 1991:51. Copenhagen, 1991.

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as toxic or harmfulCPS&Q - Classification & Labelling
Limited evidence of sense organ toxicityA Relational Database of Hazardous Chemicals and Occupational Diseases Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html, Klaassen, C., M. Amdur and J. Doull (eds.). Casarett and Doull's Toxicology. The Basic Science of Poisons, 5th Ed. Pergamon Press, NY. 1996.
One or more animal studies show any effects at moderate doses (low dose studies may be unavailable for this ingredient)EPA Categorized List of Inert Pesticide Ingredients
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Ecotoxicology

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Concern Reference
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productJACT 4(5):147-69, 1985 confirmed 02/04 IJT 25(S2), 2006
191 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyJACT 4(5):147-69, 1985 confirmed 02/04 IJT 25(S2), 2006

Data Sources

  • CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
  • JACT 4(5):147-69, 1985 confirmed 02/04 IJT 25(S2), 2006
  • Emerging PBTs from peer-reviewed literature
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • A Relational Database of Hazardous Chemicals and Occupational Diseases Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html, Nordic Council of Ministers (Nordic Allergy Project). Kriteriedokumenter fra nordisk allergiprojekt - vurdering af 50 kemiske stoffers evne til at forarsage allergi, en litteraturgennemgang. Nord 1991:51. Copenhagen, 1991.
  • A Relational Database of Hazardous Chemicals and Occupational Diseases Browse Haz-Map by Adverse Effects http://hazmap.nlm.nih.gov/hazmapadv.html, Klaassen, C., M. Amdur and J. Doull (eds.). Casarett and Doull's Toxicology. The Basic Science of Poisons, 5th Ed. Pergamon Press, NY. 1996.
  • EPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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