CAFFEINE
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Persistence and bioaccumulation (moderate)
Cancer 

Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity 

Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity 

Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
serums & essences | 61 products |
around-eye cream | 60 products |
mask | 50 products |
facial moisturizer/treatment | 49 products |
daily use with SPF | 41 products |
concealer | 39 products |
shampoo | 31 products |
conditioner | 22 products |
recreational sunscreen | 21 products |
facial cleanser | 14 products |
moisturizer | 14 products |
BB cream | 13 products |
body firming lotion | 13 products |
hair treatment/serum | 10 products |
lip liner | 10 products |
makeup primer | 10 products |
antiperspirant/deodorant | 9 products |
bronzer/highlighter | 8 products |
sunless tanning | 7 products |
eye shadow | 7 products |
anti-aging | 7 products |
exfoliant/scrub | 7 products |
toners/astringents | 6 products |
foundation | 6 products |
lip gloss | 6 products |
hair styling aide | 6 products |
body wash/cleanser | 6 products |
after shave | 4 products |
after sun product | 4 products |
setting powder/spray | 4 products |
oil controller | 3 products |
tanning oil | 3 products |
body spray | 3 products |
hair spray | 2 products |
lip plumper | 2 products |
shaving cream (men's) | 2 products |
brow liner | 2 products |
2 products | |
shaving cream | 2 products |
CC cream | 1 products |
beard cleanser | 1 products |
depilatory | 1 products |
beard care | 1 products |
hair-loss treatment | 1 products |
styling gel/lotion | 1 products |
facial powder | 1 products |
hand cream | 1 products |
mascara | 1 products |
other eye makeup | 1 products |
Persistence and bioaccumulation
Concern | Reference |
---|---|
Persistent, bioaccumulative in wildlife | Emerging PBTs from peer-reviewed literature |
Not suspected to be persistent | Environment Canada Domestic Substance List |
Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Cancer
Concern | Reference |
---|---|
Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gaps | World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 51;1991 |
Data gaps
Concern | Reference |
---|---|
27683 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
Concern | Reference |
---|---|
Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Multiple, additive exposure sources
Concern | Reference |
---|---|
Designated as safe for general or specific, limited use in food | FDA Food Additive Status |
Designated as safe for general or specific, limited use in food | FDA Everything Added to Food |
Organ system toxicity (non-reproductive)
Concern | Reference |
---|---|
Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Data Sources
- Emerging PBTs from peer-reviewed literature
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 51;1991
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
- FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
ABOUT THE SKIN DEEP® RATINGS
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
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Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer