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Data: Good

Caffeine

IMAGE SOURCE: PubChem

SEARCH PRODUCTS

Other Concerns

Persistence and bioaccumulation (moderate) and Non-reproductive organ system toxicity (low)

SYNONYMS

● 1H-PURINE-2,6-DIONE, 3,7-DIHYDRO-1,3,7-TRIMETHYL-
● 1HPURINE2,6DIONE, 3,7DIHYDRO1,3,7TRIMETHYL
● 3,7-DIHYDRO-1,3,7-TRIMETHYL- 1H-PURINE-2,6-DIONE
● 3,7-DIHYDRO-1,3,7-TRIMETHYL-1H-PURINE-2,6-DIONE
● 3,7-DIHYDRO-1,3,7-TRIMETHYL-1H-PYRINE-2,6-DIONE
● 7-METHYLTHEOPHYLLINE
● ANHYDROUS CAFFEINE
● CAFFEINE
● METHYLTHEOBROMINE

Restricted

Restricted: EWG VERIFIED products cannot contain this ingredient without adequate substantiation


Caffeine is a heterocyclic organic compound.

Common concerns

See how this product scores for common concerns.

  • LOW
    Cancer
  • LOW
    Allergies & Immunotoxicity
  • LOW
    Developmental and Reproductive Toxicity
  • LOW
    Use Restrictions

Ingredient concerns

  • CONCERNS
  • DATA SOURCES

Products with this Ingredient

Expand content Collapse content
concealer221 products
around-eye cream186 products
foundation128 products
facial moisturizer/treatment63 products
serums & essences55 products
antiperspirant/deodorant50 products
mask49 products
shampoo39 products
conditioner34 products
hair treatment/serum24 products
daily use with SPF21 products
makeup primer19 products
eye shadow18 products
facial cleanser18 products
moisturizer18 products
body wash/cleanser17 products
body firming lotion15 products
exfoliant/scrub14 products
setting powder/spray11 products
11 products
lip plumper10 products
hair-loss treatment10 products
recreational sunscreen8 products
sunless tanning8 products
hair styling aide7 products
anti-aging6 products
BB cream6 products
mascara6 products
lipstick5 products
beard cleanser5 products
bar soap4 products
blush3 products
toners/astringents3 products
fragrance for women3 products
after shave2 products
bronzer/highlighter2 products
beard care2 products
hair spray2 products
shaving cream2 products
liquid hand soap2 products
styling mousse/foam1 products
lip balm1 products
body oil1 products
body cleansing wipes1 products
tanning oil1 products
cuticle treatment1 products
antiperspirant/deodorant (men's)1 products
shaving cream (men's)1 products
makeup remover1 products
hand cream1 products
foot moisturizer1 products
other eye makeup1 products
facial powder1 products
skin fading/lightener1 products
styling gel/lotion1 products

Persistence and bioaccumulation

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CONCERN REFERENCE
Persistent, bioaccumulative in wildlifeEmerging PBTs from peer-reviewed literature
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List
Not suspected to be persistentEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

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CONCERN REFERENCE
Classified as toxic or harmful.Open scientific literature
One or more animal studies show any effects at high doses (low dose studies may be unavailable for this ingredient)Open scientific literature
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Developmental/reproductive toxicity

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CONCERN REFERENCE
One or more animal studies show any effects at moderate dosesOpen scientific literature

Cancer

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CONCERN REFERENCE
One or more in vitro tests non-mammalian cells show positive mutation resultsOpen scientific literature
Mutagen - limited evidenceOpen scientific literature
One or more in vitro tests on microorganisms show positive mutation resultsOpen scientific literature
Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gapsInt'l Agency for Research on Cancer (IARC) - Carcinogens
Not likely to be carcinogenic in humansOpen scientific literature

Ecotoxicology

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CONCERN REFERENCE
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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CONCERN REFERENCE
27683 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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CONCERN REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyOpen scientific literature

Multiple, additive exposure sources

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CONCERN REFERENCE
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
  • Emerging PBTs from peer-reviewed literature
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Open scientific/peer reviewed literature
  • IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED® mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST
Low Availability
Moderate Availability
High Availability

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