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Data: Good

Caffeine

IMAGE SOURCE: PubChem

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Other Concerns

Persistence and bioaccumulation (moderate)

SYNONYMS

1H-PURINE-2,6-DIONE, 3,7-DIHYDRO-1,3,7-TRIMETHYL-, 1HPURINE2,6DIONE, 3,7DIHYDRO1,3,7TRIMETHYL, 3,7-DIHYDRO-1,3,7-TRIMETHYL- 1H-PURINE-2,6-DIONE, 3,7-DIHYDRO-1,3,7-TRIMETHYL-1H-PURINE-2,6-DIONE, 3,7-DIHYDRO-1,3,7-TRIMETHYL-1H-PYRINE-2,6-DIONE, 7-METHYLTHEOPHYLLINE, ANHYDROUS CAFFEINE, CAFFEINE, and METHYLTHEOBROMINE

This ingredient is not currently on EWG's Restricted or Unacceptable Lists.


Caffeine is a heterocyclic organic compound.

Common concerns

See how this product scores for common concerns.

  • LOW
    Cancer
  • LOW
    Allergies & Immunotoxicity
  • LOW
    Developmental and Reproductive Toxicity
  • LOW
    Use Restrictions

Ingredient concerns

  • CONCERNS
  • DATA SOURCES

Products with this Ingredient

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around-eye cream121 products
facial moisturizer/treatment70 products
concealer69 products
mask59 products
daily use with SPF46 products
serums & essences46 products
shampoo45 products
conditioner34 products
foundation19 products
hair treatment/serum18 products
makeup primer18 products
BB cream16 products
recreational sunscreen15 products
facial cleanser15 products
moisturizer15 products
antiperspirant/deodorant15 products
body firming lotion14 products
body wash/cleanser13 products
exfoliant/scrub11 products
lip plumper10 products
hair styling aide10 products
lip liner10 products
hair-loss treatment9 products
sunless tanning9 products
anti-aging8 products
setting powder/spray8 products
8 products
lipstick4 products
toners/astringents4 products
oil controller3 products
lip balm3 products
beard care3 products
shaving cream3 products
after shave3 products
muscle/joint soreness2 products
beard cleanser2 products
bar soap2 products
shaving cream (men's)2 products
skin fading/lightener2 products
facial powder2 products
depilatory1 products
tanning oil1 products
antiperspirant/deodorant (men's)1 products
body oil1 products
CC cream1 products
eye shadow1 products
hand cream1 products
hair spray1 products
eye liner1 products
blush1 products
bronzer/highlighter1 products
foot moisturizer1 products
after sun product1 products
styling gel/lotion1 products

Persistence and bioaccumulation

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CONCERN REFERENCE
Persistent, bioaccumulative in wildlifeEmerging PBTs from peer-reviewed literature
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data gaps

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CONCERN REFERENCE
27683 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Multiple, additive exposure sources

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CONCERN REFERENCE
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food
Designated as safe for general or specific, limited use in foodFDA Food Additive Status

Cancer

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CONCERN REFERENCE
Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gapsInt'l Agency for Research on Cancer (IARC) - Carcinogens

Ecotoxicology

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CONCERN REFERENCE
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

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CONCERN REFERENCE
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List
  • Emerging PBTs from peer-reviewed literature
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.

Score legend

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST
Low Availability
Moderate Availability
High Availability

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