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CAFFEINE
Score:
Data: Good
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Persistence and bioaccumulation (moderate)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| serums & essences | 59 products |
| around-eye cream | 56 products |
| mask | 48 products |
| facial moisturizer/treatment | 45 products |
| moisturizer with SPF | 42 products |
| concealer | 37 products |
| shampoo | 29 products |
| conditioner | 22 products |
| beach & sport sunscreen | 17 products |
| BB cream | 13 products |
| moisturizer | 13 products |
| facial cleanser | 12 products |
| makeup primer | 10 products |
| lip liner | 10 products |
| body firming lotion | 10 products |
| antiperspirant/deodorant | 9 products |
| exfoliant/scrub | 7 products |
| sunless tanning | 7 products |
| anti-aging | 7 products |
| eye shadow | 7 products |
| hair treatment/serum | 6 products |
| bronzer/highlighter | 6 products |
| body wash/cleanser | 6 products |
| lip gloss | 6 products |
| foundation | 6 products |
| toners/astringents | 5 products |
| hair styling aide | 5 products |
| setting powder/spray | 4 products |
| after sun product | 4 products |
| after shave | 3 products |
| oil controller | 3 products |
| 3 products | |
| lip plumper | 2 products |
| hair spray | 2 products |
| tanning oil | 2 products |
| shaving cream (men's) | 2 products |
| brow liner | 2 products |
| CC cream | 1 products |
| depilatory | 1 products |
| styling gel/lotion | 1 products |
| facial powder | 1 products |
| hair-loss treatment | 1 products |
| shaving cream | 1 products |
| other eye makeup | 1 products |
| mascara | 1 products |
| hand cream | 1 products |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Persistent, bioaccumulative in wildlife | Emerging PBTs from peer-reviewed literature |
| Not suspected to be persistent | Environment Canada Domestic Substance List |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Cancer
| Concern | Reference |
|---|---|
| Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gaps | World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 51;1991 |
Data gaps
| Concern | Reference |
|---|---|
| 27683 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
| Concern | Reference |
|---|---|
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Multiple, additive exposure sources
| Concern | Reference |
|---|---|
| Designated as safe for general or specific, limited use in food | FDA Food Additive Status |
| Designated as safe for general or specific, limited use in food | FDA Everything Added to Food |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Data Sources
- Emerging PBTs from peer-reviewed literature
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 51;1991
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
- FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
ABOUT THE SKIN DEEP® RATINGS
EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
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