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LILIAL

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (moderate), Endocrine disruption (low), Persistence and bioaccumulation (moderate), and Non-reproductive organ system toxicity (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW_MODERATE

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is HIGH

Products with this Ingredient

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fragrance for women51 products
foundation48 products
conditioner42 products
moisturizer41 products
shampoo39 products
hair spray32 products
body wash/cleanser31 products
hair styling aide23 products
hair treatment/serum21 products
styling gel/lotion20 products
fragrance for men19 products
facial moisturizer/treatment19 products
mask18 products
facial cleanser15 products
liquid hand soap14 products
hand cream12 products
bronzer/highlighter12 products
serums & essences11 products
body spray11 products
bath oil/salts/soak10 products
exfoliant/scrub9 products
bar soap8 products
detangler7 products
makeup remover6 products
makeup primer6 products
antiperspirant/deodorant (men's)5 products
body firming lotion5 products
hair color and bleaching5 products
sunless tanning5 products
styling mousse/foam4 products
blush4 products
shaving cream4 products
body oil4 products
hand sanitizer3 products
antiperspirant/deodorant3 products
hair relaxer3 products
concealer3 products
foot moisturizer3 products
toners/astringents2 products
facial powder2 products
moisturizer with SPF2 products
eye makeup remover1 products
beard cleanser1 products
after shave1 products
depilatory1 products
BB cream1 products
damaged skin treatment1 products
around-eye cream1 products
nail treatment1 products

Allergies/immunotoxicity

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Concern Reference
Known human any toxicant or allergenOpinion on Frangrance allergens in cosmetics (2011), EU Cosmetics Directive
Possible human immune system toxicant or allergenSCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999.
Limited evidence of [[system]] toxicity or allergiesEuropean Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: 2-(4-tert-butylbenzyl)propionaldehyde; 3-(4-tert-butylphenyl)-2-methylpropanal; -; - 3-(4-tert-butylphenyl)butanal; 2 - ( 4 - tert - butylbenzyl) propionaldehyde; 2-( 4-tert-butylbenzyl) prop ion aldehyde; 2-(4-tert-Butyl benzyl)propionaldehyde; 2-(4-; cas_numbers: 80-54-6

Persistence and bioaccumulation

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Concern Reference
Persistent or bioaccumulative and moderate to high toxicity concern in humansEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Use restrictions

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Concern Reference
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn)IFRA 1/2020
Restricted in cosmetics - labeling requirement for allergensCosIng

Developmental/reproductive toxicity

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Concern Reference
Suspected of damaging fertility or the unborn childEuropean Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: 2-(4-tert-butylbenzyl)propionaldehyde; 3-(4-tert-butylphenyl)-2-methylpropanal; -; - 3-(4-tert-butylphenyl)butanal; 2 - ( 4 - tert - butylbenzyl) propionaldehyde; 2-( 4-tert-butylbenzyl) prop ion aldehyde; 2-(4-tert-Butyl benzyl)propionaldehyde; 2-(4-; cas_numbers: 80-54-6

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as medium human health priorityEnvironment Canada Domestic Substance List
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Endocrine disruption

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Concern Reference
Butylphenylmethylpropional (Lilial) demonstrated estrogenic activity by increasing the proliferation of breast cancer cells in vitro.Charles AK, Darbre PD 2009. Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro. J Appl Toxicol. 29(5): 422-34.

Data gaps

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Concern Reference
39 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data Sources

  • Opinion on Frangrance allergens in cosmetics (2011), EU Cosmetics Directive
  • SCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999.
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: 2-(4-tert-butylbenzyl)propionaldehyde; 3-(4-tert-butylphenyl)-2-methylpropanal; -; - 3-(4-tert-butylphenyl)butanal; 2 - ( 4 - tert - butylbenzyl) propionaldehyde; 2-( 4-tert-butylbenzyl) prop ion aldehyde; 2-(4-tert-Butyl benzyl)propionaldehyde; 2-(4-; cas_numbers: 80-54-6
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • IFRA 1/2020
  • European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
  • Charles AK, Darbre PD 2009. Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro. J Appl Toxicol. 29(5): 422-34.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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