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LILIAL

image source: PubChem

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Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms

  • Use restrictions (moderate), Endocrine disruption (low), Persistence and bioaccumulation (moderate), and Non-reproductive organ system toxicity (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW_MODERATE

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is HIGH

Products with this Ingredient

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shampoo99 products
conditioner87 products
fragrance for women75 products
foundation74 products
hair treatment/serum61 products
hair spray53 products
moisturizer53 products
hair styling aide52 products
body wash/cleanser46 products
fragrance for men36 products
styling gel/lotion33 products
facial moisturizer/treatment32 products
facial cleanser28 products
liquid hand soap27 products
mask27 products
body firming lotion20 products
hand cream18 products
bar soap16 products
body spray16 products
exfoliant/scrub15 products
bath oil/salts/soak14 products
bronzer/highlighter12 products
serums & essences11 products
daily use with SPF10 products
9 products
hair color and bleaching9 products
makeup primer8 products
detangler8 products
styling mousse/foam7 products
antiperspirant/deodorant (men's)6 products
makeup remover6 products
body oil6 products
shaving cream6 products
sunless tanning5 products
setting powder/spray5 products
foot moisturizer5 products
blush4 products
concealer4 products
hair relaxer4 products
facial powder4 products
antiperspirant/deodorant4 products
toners/astringents4 products
hand sanitizer3 products
beard oil3 products
lip gloss3 products
BB cream3 products
after shave3 products
beard care2 products
anti-aging2 products
bubble bath2 products
nail treatment1 products
damaged skin treatment1 products
beard cleanser1 products
eye makeup remover1 products
depilatory1 products
baby lotion1 products
foot cleansing1 products
around-eye cream1 products
after sun product1 products
body powder1 products

Allergies/immunotoxicity

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Concern Reference
Known human any toxicant or allergenOpinion on Frangrance allergens in cosmetics (2011), EU Cosmetics Directive
Possible human immune system toxicant or allergenSCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999.
Limited evidence of [[system]] toxicity or allergiesEuropean Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: 2-(4-tert-butylbenzyl)propionaldehyde; 3-(4-tert-butylphenyl)-2-methylpropanal; -; - 3-(4-tert-butylphenyl)butanal; 2 - ( 4 - tert - butylbenzyl) propionaldehyde; 2-( 4-tert-butylbenzyl) prop ion aldehyde; 2-(4-tert-Butyl benzyl)propionaldehyde; 2-(4-; cas_numbers: 80-54-6

Persistence and bioaccumulation

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Concern Reference
Persistent or bioaccumulative and moderate to high toxicity concern in humansEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Use restrictions

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Concern Reference
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn)IFRA 1/2020
Restricted in cosmetics - labeling requirement for allergensCosIng

Developmental/reproductive toxicity

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Concern Reference
Suspected of damaging fertility or the unborn childEuropean Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: 2-(4-tert-butylbenzyl)propionaldehyde; 3-(4-tert-butylphenyl)-2-methylpropanal; -; - 3-(4-tert-butylphenyl)butanal; 2 - ( 4 - tert - butylbenzyl) propionaldehyde; 2-( 4-tert-butylbenzyl) prop ion aldehyde; 2-(4-tert-Butyl benzyl)propionaldehyde; 2-(4-; cas_numbers: 80-54-6

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as medium human health priorityEnvironment Canada Domestic Substance List
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Endocrine disruption

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Concern Reference
Butylphenylmethylpropional (Lilial) demonstrated estrogenic activity by increasing the proliferation of breast cancer cells in vitro.Charles AK, Darbre PD 2009. Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro. J Appl Toxicol. 29(5): 422-34.

Data gaps

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Concern Reference
39 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data Sources

  • Opinion on Frangrance allergens in cosmetics (2011), EU Cosmetics Directive
  • SCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999.
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: 2-(4-tert-butylbenzyl)propionaldehyde; 3-(4-tert-butylphenyl)-2-methylpropanal; -; - 3-(4-tert-butylphenyl)butanal; 2 - ( 4 - tert - butylbenzyl) propionaldehyde; 2-( 4-tert-butylbenzyl) prop ion aldehyde; 2-(4-tert-Butyl benzyl)propionaldehyde; 2-(4-; cas_numbers: 80-54-6
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • IFRA 1/2020
  • European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
  • Charles AK, Darbre PD 2009. Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro. J Appl Toxicol. 29(5): 422-34.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

ABOUT THE SKIN DEEP® RATINGS

EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer

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