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LILIAL
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (moderate), Endocrine disruption (low), Persistence and bioaccumulation (moderate), and Non-reproductive organ system toxicity (moderate)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| fragrance for women | 50 products |
| moisturizer | 41 products |
| conditioner | 41 products |
| shampoo | 35 products |
| hair spray | 31 products |
| body wash/cleanser | 29 products |
| hair styling aide | 21 products |
| styling gel/lotion | 19 products |
| mask | 18 products |
| hair treatment/serum | 18 products |
| fragrance for men | 17 products |
| facial cleanser | 15 products |
| facial moisturizer/treatment | 14 products |
| liquid hand soap | 13 products |
| bronzer/highlighter | 12 products |
| hand cream | 12 products |
| serums & essences | 11 products |
| bath oil/salts/soak | 10 products |
| body spray | 10 products |
| bar soap | 8 products |
| exfoliant/scrub | 7 products |
| detangler | 7 products |
| hair color and bleaching | 5 products |
| sunless tanning | 5 products |
| makeup remover | 5 products |
| makeup primer | 5 products |
| styling mousse/foam | 4 products |
| foundation | 4 products |
| body oil | 4 products |
| shaving cream | 4 products |
| body firming lotion | 4 products |
| antiperspirant/deodorant (men's) | 4 products |
| blush | 4 products |
| concealer | 3 products |
| antiperspirant/deodorant | 3 products |
| hand sanitizer | 3 products |
| hair relaxer | 3 products |
| foot moisturizer | 3 products |
| moisturizer with SPF | 2 products |
| toners/astringents | 2 products |
| facial powder | 2 products |
| nail treatment | 1 products |
| after shave | 1 products |
| BB cream | 1 products |
| damaged skin treatment | 1 products |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| Known human any toxicant or allergen | Opinion on Frangrance allergens in cosmetics (2011), EU Cosmetics Directive |
| Possible human immune system toxicant or allergen | SCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999. |
| Limited evidence of [[system]] toxicity or allergies | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: 2-(4-tert-butylbenzyl)propionaldehyde; 3-(4-tert-butylphenyl)-2-methylpropanal; -; - 3-(4-tert-butylphenyl)butanal; 2 - ( 4 - tert - butylbenzyl) propionaldehyde; 2-( 4-tert-butylbenzyl) prop ion aldehyde; 2-(4-tert-Butyl benzyl)propionaldehyde; 2-(4-; cas_numbers: 80-54-6 |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Persistent or bioaccumulative and moderate to high toxicity concern in humans | Environment Canada Domestic Substance List |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Use restrictions
| Concern | Reference |
|---|---|
| Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Fragrance subject to restrictions: safe only within recommended use or concentration limitsn) | IFRA 1/2020 |
| Restricted in cosmetics - labeling requirement for allergens | CosIng |
Developmental/reproductive toxicity
| Concern | Reference |
|---|---|
| Suspected of damaging fertility or the unborn child | European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: 2-(4-tert-butylbenzyl)propionaldehyde; 3-(4-tert-butylphenyl)-2-methylpropanal; -; - 3-(4-tert-butylphenyl)butanal; 2 - ( 4 - tert - butylbenzyl) propionaldehyde; 2-( 4-tert-butylbenzyl) prop ion aldehyde; 2-(4-tert-Butyl benzyl)propionaldehyde; 2-(4-; cas_numbers: 80-54-6 |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as medium human health priority | Environment Canada Domestic Substance List |
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Endocrine disruption
| Concern | Reference |
|---|---|
| Butylphenylmethylpropional (Lilial) demonstrated estrogenic activity by increasing the proliferation of breast cancer cells in vitro. | Charles AK, Darbre PD 2009. Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro. J Appl Toxicol. 29(5): 422-34. |
Data gaps
| Concern | Reference |
|---|---|
| 39 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
| Concern | Reference |
|---|---|
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Data Sources
- Opinion on Frangrance allergens in cosmetics (2011), EU Cosmetics Directive
- SCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999.
- European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: 2-(4-tert-butylbenzyl)propionaldehyde; 3-(4-tert-butylphenyl)-2-methylpropanal; -; - 3-(4-tert-butylphenyl)butanal; 2 - ( 4 - tert - butylbenzyl) propionaldehyde; 2-( 4-tert-butylbenzyl) prop ion aldehyde; 2-(4-tert-Butyl benzyl)propionaldehyde; 2-(4-; cas_numbers: 80-54-6
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- IFRA 1/2020
- European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
- Charles AK, Darbre PD 2009. Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro. J Appl Toxicol. 29(5): 422-34.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
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