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BUTYLPARABEN

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (moderate), Endocrine disruption (high), and Biochemical or cellular level changes (moderate)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is MODERATE

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is MODERATE

Products with this Ingredient

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foundation140 products
concealer58 products
eye liner42 products
facial powder23 products
lipstick23 products
blush20 products
bronzer/highlighter18 products
brow liner17 products
mascara16 products
eye shadow11 products
facial cleanser8 products
facial moisturizer/treatment7 products
lip liner7 products
setting powder/spray7 products
moisturizer6 products
mask6 products
sunless tanning5 products
conditioner5 products
styling gel/lotion4 products
anti-aging3 products
styling mousse/foam3 products
daily use with SPF3 products
body wash/cleanser3 products
other eye makeup3 products
hair treatment/serum3 products
hair styling aide3 products
hair color and bleaching2 products
makeup remover2 products
lip gloss2 products
makeup primer2 products
recreational sunscreen2 products
damaged skin treatment2 products
hair-loss treatment2 products
hair spray1 products
around-eye cream1 products
baby lotion1 products
fragrance for women1 products
eye makeup remover1 products
exfoliant/scrub1 products
toners/astringents1 products
shaving cream1 products
after shave1 products
body powder1 products
hair relaxer1 products
baby sunscreen1 products
polish remover1 products

Endocrine disruption

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Concern Reference
Known human any disruptorOpen scientific literature
Human endocrine disruptor - strong evidenceEuropean Commission on Endocrine Disruption
Limited evidence of endocrine disruptionOpen scientific literature
One or more studies show significant wildlife and the environment disruptionEuropean Commission on Endocrine Disruption
One or more studies show weak endocrine disruptionOpen scientific literature
One or more studies show weak endocrine disruptionEWG Assessment of Open Scientific Literature

Developmental/reproductive toxicity

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Concern Reference
Possible human reproductive or developmental toxinOpen scientific literature
One or more animal studies show any effects at very low dosesOpen scientific literature
One or more animal studies show any effects at low dosesOpen scientific literature

Allergies/immunotoxicity

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Concern Reference
Human skin toxicant or allergen - strong evidenceEWG Assessment of Open Scientific Literature
One or more human case studies show possible immune or allergenic effectsOpen scientific literature

Use restrictions

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Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - anyOpen scientific literature
Determined safe for use in cosmetics, subject to concentration or use limitations - anyCosmetic Ingredient Review Assessments
Determined safe for use in cosmetics, subject to concentration or use limitations - anyOpen scientific literature

Biochemical or cellular level changes

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Concern Reference
Interferes with gene expresionOpen scientific literature

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productCosmetic Ingredient Review Assessments
Safety assessment was based on related chemicalCosmetic Ingredient Review Assessments
308 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List
Not suspected to be persistentEnvironment Canada Domestic Substance List

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyCosmetic Ingredient Review Assessments

Data Sources

  • Open scientific/peer reviewed literature
  • EU (European Union)- Strategy for Endocrine Disrupters 2007. Commision on endocrin disruption requested by the European Parliament in 1998.
  • EWG Assessment of Open Scientific Literature
  • CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

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