BUTOXYETHANOL
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (moderate), Non-reproductive organ system toxicity (low), Irritation (skin, eyes, or lungs) (high), and Occupational hazards (high)
Cancer 

Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity 

Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity 

Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
Irritation (skin, eyes, or lungs)
Concern | Reference |
---|---|
Classified as irritant | CPS&Q - Classification & Labelling |
Human any irritant - strong evidence | JACT 15(6):462-526, 1996 confirmed 02/02 IJT 24(S1):18-20, 2005 |
Occupational hazards
Concern | Reference |
---|---|
Allowed workplace exposures restricted to low doses | CPS&Q - Classification & Labelling |
Use restrictions
Concern | Reference |
---|---|
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | Canada - Prohibited and Restricted Cosmetics Ingredients |
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any | CosIng |
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | JACT 15(6):462-526, 1996 confirmed 02/02 IJT 24(S1):18-20, 2005 |
Cancer
Concern | Reference |
---|---|
Limited evidence of carcinogenicity | Amer Conf of Gov't Industrial Hygienists - Carcinogens |
Limited evidence of carcinogenicity | EPA (US. Environmental Protection Agency). Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986 guidelines. |
Limited or incomplete evidence of cancer according to safety/hazard data – government assessment cannot classify as human carcinogen due to data gaps | World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 88;2006 |
A 2010 EPA re-evaluation found that ethylene glycol monobutyl ether is not likely to be carcinogenic to humans for exposures at or below reference concentrations or doses and in the absence of critical noncancer effects. | US. Environmental Protection Agency. 2010. Toxicological Review of Ethylene Glycol Monobutyl Ether (EGBE) (CAS No. 111-76-2) In Support of Summary Information on the Integrated Risk Information System (IRIS). EPA/635/R-08/006F. |
Developmental/reproductive toxicity
Concern | Reference |
---|---|
Limited evidence of reproductive toxicity | National Library of Medicine HazMap |
Organ system toxicity (non-reproductive)
Concern | Reference |
---|---|
Classified as toxic or harmful | CPS&Q - Classification & Labelling |
Limited evidence of gastrointestinal or liver toxicity | National Library of Medicine HazMap |
Limited evidence of cardiovascular or blood toxicity | Agency for Toxic Substances and Disease Registry Minimal risk Levels for Hazardous Substances. January 2004. http://www.atsdr.cdc.gov/mrls.html, LaDou, J. (ed.). Occupational Medicine. Appleton & Lange, Norwalk, CN. 1990., Malachowsky, M.J. Health Effects of Toxic Substances. Government Institutes. Rockville, MD 1995., California EPA, Office of Environmental Health Hazard Assessment. Air Toxics Hot Spots Program Risk Assessment Guidelines, Part III: Technical Support Document 'Determination of Noncancer Chronic Reference Exposure Levels'. Includes all Chronic Reference Exposure Levels (CRELs) adopted by OEHHA as of August 2003 (http://www.oehha.ca.gov/air/chronic_rels/AllChrels.html, plus draft CRELS proposed through March 2004 (http://www.oehha.ca.gov/air/chronic_rels/index.html., National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation. |
One or more animal studies show any effects at moderate doses (low dose studies may be unavailable for this ingredient) | EPA Categorized List of Inert Pesticide Ingredients |
reproductive - weight of evidence unknown/unassessed/unreview: published lit review or major tox study | National Library of Medicine HazMap |
Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Classified as a low human health priority | Environment Canada Domestic Substance List |
Data gaps
Concern | Reference |
---|---|
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | JACT 15(6):462-526, 1996 confirmed 02/02 IJT 24(S1):18-20, 2005 |
311 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
Concern | Reference |
---|---|
Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Multiple, additive exposure sources
Concern | Reference |
---|---|
Designated as safe for general or specific, limited use in food | FDA Food Additive Status |
Designated as safe for general or specific, limited use in food | FDA Everything Added to Food |
Informational
Concern | Reference |
---|---|
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Determined safe for use in cosmetics up to a specified concentration limit | JACT 15(6):462-526, 1996 confirmed 02/02 IJT 24(S1):18-20, 2005 |
Neurotoxicity
Concern | Reference |
---|---|
nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study | National Library of Medicine HazMap |
Persistence and bioaccumulation
Concern | Reference |
---|---|
Not suspected to be persistent | Environment Canada Domestic Substance List |
Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
- CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
- JACT 15(6):462-526, 1996 confirmed 02/02 IJT 24(S1):18-20, 2005
- Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
- European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
- ACGIH (American Conference of Governmental Industrial Hygienists) 2008. ACGIH cancer classification system. www.acgih.org.
- EPA (US. Environmental Protection Agency). Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986 guidelines.
- World Health Organization, International Agency for Research on Cancer IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans. Lists of Group 1, 2a, and 2b substances can be obtained. http://monographs.iarc.fr/ENG/Classification/index.php; Vol 88;2006
- US. Environmental Protection Agency. 2010. Toxicological Review of Ethylene Glycol Monobutyl Ether (EGBE) (CAS No. 111-76-2) In Support of Summary Information on the Integrated Risk Information System (IRIS). EPA/635/R-08/006F.
- NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
- Agency for Toxic Substances and Disease Registry Minimal risk Levels for Hazardous Substances. January 2004. http://www.atsdr.cdc.gov/mrls.html, LaDou, J. (ed.). Occupational Medicine. Appleton & Lange, Norwalk, CN. 1990., Malachowsky, M.J. Health Effects of Toxic Substances. Government Institutes. Rockville, MD 1995., California EPA, Office of Environmental Health Hazard Assessment. Air Toxics Hot Spots Program Risk Assessment Guidelines, Part III: Technical Support Document 'Determination of Noncancer Chronic Reference Exposure Levels'. Includes all Chronic Reference Exposure Levels (CRELs) adopted by OEHHA as of August 2003 (http://www.oehha.ca.gov/air/chronic_rels/AllChrels.html, plus draft CRELS proposed through March 2004 (http://www.oehha.ca.gov/air/chronic_rels/index.html., National Institute for Occupational Safety and Health's Registry of Toxic Effects of Chemical Substances. See Environmental Defense's Suspect Hazard Identification documentation.
- EPA (U.S. Environmental Protection Agency). 1987 & 2005. Office of Pesticide Programs. Inert (other) Pesticide Ingredients in Pesticide Products - Categorized List of Inert (other) Pesticide Ingredients.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
- FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
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