EWG Skin Deep® | What is BIOTIN

HOW WE DETERMINE SCORES Learn more About EWG VERIFIED®

Data: Fair

Biotin

IMAGE SOURCE: PubChem

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Other Concerns

SYNONYMS

● 1H-THIENO[3,4-D]IMIDAZOLE-4-PENTANOIC ACID, HEXAHYDRO-2-OXO-, (3AS,4S,6AR)-

● 1H-THIENO[3,4-D]IMIDAZOLE-4-PENTANOIC ACID, HEXAHYDRO-2-OXO-, [3AS-(3AA ,4B,6AA)]-

● 1HTHIENO[3,4D]IMIDAZOLE4PENTANOIC ACID, HEXAHYDRO2OXO, [3AS(3AÃ ,4 ,6AÃ )]

● BIOTIN

● COENZYME R

● HEXAHYDRO-2-OXO- [3AS-(3AA ,4B,6AA)]- 1H-THIENO[3,4-D]IMIDAZOLE-4-PENTANOIC ACID

● VITAMIN B7

● VITAMIN H

● [3AS-(3AA ,4B,6AA )]-HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOLE-4-PENTANOIC ACID

● [3AS-(3AA ,4B,6AA)]- 1H-THIENO[3,4-D]IMIDAZOLE-4-PENTANOIC ACID, HEXAHYDRO-2-OXO-

Restricted

Restricted: EWG VERIFIED products cannot contain this ingredient without adequate substantiation

Common concerns

See how this product scores for common concerns.

LOW

Cancer
LOW

Allergies & Immunotoxicity
LOW

Developmental and Reproductive Toxicity
LOW

Use Restrictions

Ingredient concerns

CONCERNS
DATA SOURCES

Products with this Ingredient

shampoo	233 products
conditioner	223 products
hair treatment/serum	88 products
nail polish	68 products
hair styling aide	38 products
mascara	35 products
serums & essences	30 products
mask	27 products
around-eye cream	25 products
facial moisturizer/treatment	21 products
brow liner	19 products
hair color and bleaching	16 products
hair-loss treatment	15 products
concealer	14 products
styling gel/lotion	12 products
body wash/cleanser	11 products
moisturizer	9 products
toners/astringents	9 products
hair spray	9 products
foundation	9 products
nail treatment	6 products
eye liner	5 products
hand cream	5 products
eyelash glue	5 products
facial cleanser	5 products
detangler	4 products
other eye makeup	4 products
anti-aging	4 products
setting powder/spray	3 products
daily use with SPF	3 products
makeup primer	3 products
makeup remover	2 products
exfoliant/scrub	2 products
beard care	1 products
styling mousse/foam	1 products
facial powder	1 products
facial cleansing wipes	1 products
lip balm	1 products
skin fading/lightener	1 products
blush	1 products
bar soap	1 products
	1 products

Data gaps

CONCERN	REFERENCE
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product	Cosmetic Ingredient Review Assessments
37327 studies in PubMed science library may include information on the toxicity of this chemical	NLM PubMed

Informational

CONCERN	REFERENCE
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any	Cosmetic Ingredient Review Assessments

Ecotoxicology

CONCERN	REFERENCE
Not suspected to be an environmental toxin	Environment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

CONCERN	REFERENCE
Classified as not expected to be potentially toxic or harmful	Environment Canada Domestic Substance List

Persistence and bioaccumulation

CONCERN	REFERENCE
Not suspected to be persistent	Environment Canada Domestic Substance List
Not suspected to be bioaccumulative	Environment Canada Domestic Substance List

Multiple, additive exposure sources

CONCERN	REFERENCE
Designated as safe for general or specific, limited use in food	FDA Food Additive Status
Designated as safe for general or specific, limited use in food	FDA Everything Added to Food

CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

Understanding scores

Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.

Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.

HOW WE DETERMINE SCORES

Hazard score

The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED^® mark means a product meets EWG’s strictest criteria for transparency and health.

Data availability

The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.

NONE LIMITED FAIR GOOD ROBUST

Low Availability

Moderate Availability

High Availability