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BHT

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Endocrine disruption (low), Non-reproductive organ system toxicity (moderate), and Irritation (skin, eyes, or lungs) (moderate)

Cancer

Cancer concern is LOW_MODERATE

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW_MODERATE

Products with this Ingredient

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lipstick406 products
foundation267 products
lip gloss210 products
eye liner191 products
antiperspirant/deodorant163 products
eye shadow145 products
concealer133 products
body wash/cleanser132 products
moisturizer105 products
fragrance for women97 products
facial moisturizer/treatment95 products
mascara95 products
daily use with SPF92 products
fragrance for men83 products
recreational sunscreen71 products
serums & essences67 products
antiperspirant/deodorant (men's)65 products
bronzer/highlighter61 products
hair treatment/serum60 products
lip balm55 products
brow liner54 products
lip liner52 products
lip balm with SPF44 products
conditioner42 products
shampoo39 products
blush38 products
body firming lotion37 products
facial cleanser36 products
shaving cream35 products
facial powder33 products
makeup primer31 products
body oil28 products
hand cream24 products
exfoliant/scrub24 products
mask23 products
liquid hand soap23 products
body spray22 products
hair styling aide22 products
anti-aging20 products
hair spray20 products
sunless tanning19 products
around-eye cream18 products
lip plumper16 products
shaving cream (men's)15 products
toothpaste15 products
BB cream12 products
after shave11 products
setting powder/spray11 products
nail glue11 products
styling gel/lotion10 products
hair color and bleaching10 products
hair-loss treatment10 products
bath oil/salts/soak8 products
8 products
bar soap7 products
other eye makeup7 products
toners/astringents6 products
makeup remover6 products
CC cream6 products
baby sunscreen6 products
bubble bath5 products
nail polish4 products
hand sanitizer4 products
beard oil4 products
skin fading/lightener3 products
cuticle treatment3 products
foot moisturizer3 products
polish remover3 products
baby shampoo3 products
depilatory2 products
nail treatment2 products
detangler2 products
baby soap2 products
foot odor control1 products
baby lotion1 products
tanning oil1 products
oil controller1 products
styling mousse/foam1 products
damaged skin treatment1 products
beard care1 products
beard cleanser1 products

Cancer

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Concern Reference
The European Food Safety Authority reports that this substance can cause liver cancer in animals.European Food Safety Authority 2012. EFSA. 2012. Panel on Food Additives and Nutrient Sources added to Food (ANS); Scientific Opinion on the re-evaluation of Butylated hydroxytoluene BHT (E 321) as a food additive. EFSA Journal 10(3), 2588.
This peer-reviewed study reports this substance is a tumor promoter.Vikism, Haris G, Alexander S. Krupnick, Jay W. Tichelaar, Pengyuan Liu, Jihong Zhu, Amy Rymaszewski, Lauren Stein, Andrew Franklin, Andrew E. Gelman & Ming You. 2011. Neutrophils are required for 3-methylcholanthrene-initiated, butylated hydroxytoluene-promoted lung carcinogenesis. Molecular carcinogenesis.
This peer-reviewed study reports this substance is a tumor promoter.Shearn, Colin T, Kristofer S. Fritz & John A. Thompson. 2011. Protein damage from electrophiles and oxidants in lungs of mice chronically exposed to the tumor promoter butylated hydroxytoluene. Chemico-biological interactions 192(3), 278-86.

Allergies/immunotoxicity

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Concern Reference
One or more human case studies show significant any or allergenic effectsNational Library of Medicine HazMap

Irritation (skin, eyes, or lungs)

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Concern Reference
Upper respiratory tract irritationAmerican Conference of Governmental Industrial Hygienists (ACGIH) 2010. Threshold Limit Values for Chemical Substances.

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List

Endocrine disruption

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Concern Reference
The European Food Safety Authority reports that this substance can cause allergies in people.European Food Safety Authority 2012. EFSA. 2012. Panel on Food Additives and Nutrient Sources added to Food (ANS); Scientific Opinion on the re-evaluation of Butylated hydroxytoluene BHT (E 321) as a food additive. EFSA Journal 10(3), 2588.

Developmental/reproductive toxicity

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Concern Reference
A peer-reviewed study found this substance caused adverse developmental effects in rats.Vorhees, C, R. E. Butcher, R. L. Brunner & T. J. Sobotka. 1981. Developmental neurobehavioural toxicity of butylated hydroxytoluene in rats. Food and cosmetics toxicology 19(2), 153-62.

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productIJT 21(S2):19-94, 2002
5406 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyIJT 21(S2):19-94, 2002

Data Sources

  • European Food Safety Authority 2012. EFSA. 2012. Panel on Food Additives and Nutrient Sources added to Food (ANS); Scientific Opinion on the re-evaluation of Butylated hydroxytoluene BHT (E 321) as a food additive. EFSA Journal 10(3), 2588.
  • Vikism, Haris G, Alexander S. Krupnick, Jay W. Tichelaar, Pengyuan Liu, Jihong Zhu, Amy Rymaszewski, Lauren Stein, Andrew Franklin, Andrew E. Gelman & Ming You. 2011. Neutrophils are required for 3-methylcholanthrene-initiated, butylated hydroxytoluene-promoted lung carcinogenesis. Molecular carcinogenesis.
  • Shearn, Colin T, Kristofer S. Fritz & John A. Thompson. 2011. Protein damage from electrophiles and oxidants in lungs of mice chronically exposed to the tumor promoter butylated hydroxytoluene. Chemico-biological interactions 192(3), 278-86.
  • NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
  • American Conference of Governmental Industrial Hygienists (ACGIH) 2010. Threshold Limit Values for Chemical Substances.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Vorhees, C, R. E. Butcher, R. L. Brunner & T. J. Sobotka. 1981. Developmental neurobehavioural toxicity of butylated hydroxytoluene in rats. Food and cosmetics toxicology 19(2), 153-62.
  • IJT 21(S2):19-94, 2002
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

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