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BENZYL SALICYLATE

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Endocrine disruption (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is HIGH

Products with this Ingredient

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fragrance for women72 products
shampoo50 products
conditioner45 products
foundation43 products
moisturizer30 products
body wash/cleanser28 products
hair treatment/serum28 products
moisturizer with SPF24 products
facial moisturizer/treatment24 products
fragrance for men20 products
concealer20 products
lipstick19 products
hair styling aide16 products
hair spray16 products
serums & essences15 products
styling gel/lotion14 products
facial cleanser13 products
bronzer/highlighter12 products
hand cream12 products
liquid hand soap12 products
body spray11 products
antiperspirant/deodorant10 products
hair color and bleaching9 products
blush9 products
bar soap8 products
lip liner8 products
mask7 products
body firming lotion7 products
lip balm7 products
bath oil/salts/soak6 products
exfoliant/scrub6 products
sunless tanning6 products
antiperspirant/deodorant (men's)5 products
body oil5 products
facial powder4 products
detangler4 products
CC cream4 products
styling mousse/foam3 products
lip gloss3 products
toners/astringents3 products
baby lotion3 products
after shave2 products
diaper cream2 products
makeup primer2 products
beach & sport sunscreen2 products
foot moisturizer2 products
nail treatment2 products
makeup remover1 products
shaving cream1 products
polish remover1 products
lip plumper1 products
hair relaxer1 products
bubble bath1 products
cuticle treatment1 products
around-eye cream1 products
BB cream1 products

Allergies/immunotoxicity

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Concern Reference
Known human immune system toxicant or allergenSCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999.
Human [[system]] toxicant or allergen - strong evidenceEnvironmental Protection Agency (EPA) 2018. Safer Chemical Ingredients List (2018-02-28). Appears as: CAS: 118-58-1; List Name: Benzyl salicylate; TSCA Chemical Name: Benzoic acid, 2-hydroxy-, phenylmethyl ester
Limited evidence of [[system]] toxicity or allergiesEuropean Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Benzyl salicylate; benzyl 2-hydroxybenzoate; -; 2-hydroxybenzoic acid phenylmethyl ester; Benzoic acid, 2-hydroxy-, phenylmethyl ester; benzyl 2-hydroxybenzoaat; Benzyl 2-hydroxybenzoate; Benzyl 2-hydroxybenzoateBenzyl salicylate; BENZYL SALICILATE; B; cas_numbers: 118-58-1

Endocrine disruption

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Concern Reference
Benzyl salicylate demonstrated estrogenic activity by increasing the proliferation of breast cancer cells in vitro.Charles AK, Darbre PD 2009. Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro. J Appl Toxicol. 29(5): 422-34.

Ecotoxicology

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Concern Reference
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
49 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Use restrictions

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Concern Reference
Restricted in cosmetics - labeling requirement for allergensCosIng

Data Sources

  • SCCPNFP, 1999 "Opinion Concerning Fragrance Allergy In Consumers," Scientific Committee On Cosmetic Products And Non-Food Products. SCCNFP/0017/98 Final, December 1999.
  • Environmental Protection Agency (EPA) 2018. Safer Chemical Ingredients List (2018-02-28). Appears as: CAS: 118-58-1; List Name: Benzyl salicylate; TSCA Chemical Name: Benzoic acid, 2-hydroxy-, phenylmethyl ester
  • European Chemicals Agency (ECHA) 2018. GHS Data from ECHA Website. Appears as: chemical_names: Benzyl salicylate; benzyl 2-hydroxybenzoate; -; 2-hydroxybenzoic acid phenylmethyl ester; Benzoic acid, 2-hydroxy-, phenylmethyl ester; benzyl 2-hydroxybenzoaat; Benzyl 2-hydroxybenzoate; Benzyl 2-hydroxybenzoateBenzyl salicylate; BENZYL SALICILATE; B; cas_numbers: 118-58-1
  • Charles AK, Darbre PD 2009. Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro. J Appl Toxicol. 29(5): 422-34.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
  • European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .

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