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AVOBENZONE

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (moderate) and Contamination concerns (high)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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beach & sport sunscreen411 products
moisturizer with SPF199 products
lip balm with SPF54 products
fragrance for women26 products
baby sunscreen15 products
fragrance for men9 products
blush6 products
bronzer/highlighter6 products
makeup with SPF3 products
after shave2 products
facial cleanser2 products
body wash/cleanser1 products
tanning oil1 products
bar soap1 products
facial moisturizer/treatment1 products
body spray1 products
serums & essences1 products
hair treatment/serum1 products

Contamination concerns

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Enhanced skin absorption

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Concern Reference
Absorbs into the skinKlinubol P, Asawanonda P, Wanichwecharungruang SP Transdermal penetration of UV filters. Skin Pharmacol Physiol 2008; 21 (1):23-9.

Decreased skin absorption

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Concern Reference
Limited potential to absorb into the skin.Hayden CGJ, Cross SE, Anderson C, Saunders NA, Roberts MS 2005. Sunscreen penetration of human skin and related keratinocyte toxicity after topical application. Skin Pharmacology and Physiology 18(4): 170-174.

Use restrictions

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Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Japan - restricted for use in cosmetics (concentration limit)Japan's Standards for Cosmetics

Cancer

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Concern Reference
One or more in vitro tests on mammalian cells show positive mutation resultsDamiani, E, L. Greci, et al. (1999). "Nitroxide radicals protect dna from damage when illuminated in vitro in the presence of dibenzoylmethane and a common sunscreen ingredient." Free Radical Biology and Medicine 26: 809-816.

Allergies/immunotoxicity

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Concern Reference
Associated with immunotoxicity or allergiesStitt WZD, Scott GA, Martin RE, Gaspari AA 1996. Multiple chemical sensitivities, including inatrogenic allergic contact dermatitis, in a patient with chronic actinic dermatitis: implication for management. American Journal of Contact Dermatitis 7(3): 166-170.; Buckley D, Wayte J, O

Data gaps

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Concern Reference
312 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Ecotoxicology

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Concern Reference
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Persistence and bioaccumulation

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Concern Reference
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Data Sources

  • Klinubol P, Asawanonda P, Wanichwecharungruang SP Transdermal penetration of UV filters. Skin Pharmacol Physiol 2008; 21 (1):23-9.
  • Hayden CGJ, Cross SE, Anderson C, Saunders NA, Roberts MS 2005. Sunscreen penetration of human skin and related keratinocyte toxicity after topical application. Skin Pharmacology and Physiology 18(4): 170-174.
  • Japan Ministry of Health, Labour and Welfare. 2006. Standards for Cosmetics. Evaluation and Licensing Division. Pharmaceutical and Food Safety Bureau.
  • Damiani, E, L. Greci, et al. (1999). "Nitroxide radicals protect dna from damage when illuminated in vitro in the presence of dibenzoylmethane and a common sunscreen ingredient." Free Radical Biology and Medicine 26: 809-816.
  • Stitt WZD, Scott GA, Martin RE, Gaspari AA 1996. Multiple chemical sensitivities, including inatrogenic allergic contact dermatitis, in a patient with chronic actinic dermatitis: implication for management. American Journal of Contact Dermatitis 7(3): 166-170.; Buckley D, Wayte J, O
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.

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