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ANTHEMIS NOBILIS (CHAMOMILE) FLOWER EXTRACT

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption, Use restrictions (low), Neurotoxicity (low), Non-reproductive organ system toxicity (low), and Irritation (skin, eyes, or lungs) (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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foundation32 products
conditioner28 products
shampoo27 products
facial cleanser19 products
facial moisturizer/treatment18 products
moisturizer13 products
body firming lotion13 products
body wash/cleanser12 products
serums & essences11 products
exfoliant/scrub10 products
mask9 products
hand cream9 products
moisturizer with SPF9 products
hair treatment/serum8 products
BB cream7 products
hair styling aide7 products
hair spray6 products
makeup remover6 products
baby lotion5 products
concealer5 products
styling gel/lotion5 products
detangler4 products
baby shampoo4 products
toners/astringents3 products
eye liner3 products
baby wipes3 products
mascara3 products
bar soap2 products
makeup primer2 products
other eye makeup2 products
foot moisturizer2 products
anti-aging2 products
baby soap2 products
around-eye cream2 products
shaving cream (men's)1 products
bronzer/highlighter1 products
body spray1 products
nail treatment1 products
body oil1 products
bubble bath1 products
beach & sport sunscreen1 products
hair color and bleaching1 products
shaving cream1 products
beard cleanser1 products
baby toothpaste1 products
facial powder1 products
muscle/joint soreness1 products
setting powder/spray1 products
bath oil/salts/soak1 products
diaper cream1 products
liquid hand soap1 products
styling mousse/foam1 products
skin fading/lightener1 products

Enhanced skin absorption

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Concern Reference
Penetration enhancerIJT 18(S3):33-40, 1999

Developmental/reproductive toxicity

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Concern Reference
Weak evidence of possible pregnancy/birth effects associated with chamomile consumption.Laura Cuzzolin, Francesco Francini-Pesenti, Giovanna Verlato, Marco Joppi, Paola Baldelli & Giuseppina Benoni 2010. Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome. Pharmacoepidemiology and drug safety 19(11), 1151-8.

Allergies/immunotoxicity

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Concern Reference
Safe for use when formulated to be non-sensitizingCosmetic Ingredient Review (CIR) 2015. CIR Assessments. Appears as: listid: CIR-3040; Chemical_Name: Anthemis nobilis flower extract; ; ; Classification: QQQ02, QQQ54;
May cause an allergic skin reaction.European Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7

Irritation (skin, eyes, or lungs)

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Concern Reference
Causes skin irritationEuropean Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7

Organ system toxicity (non-reproductive)

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Concern Reference
May be fatal if swallowed and enters airwaysEuropean Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Use restrictions

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Concern Reference
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsIJT 36(Suppl 1):57-66, 2017

Neurotoxicity

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Concern Reference
Derivatives of this species demonstrate neuromuscular effects in animals.Zsolt Sándor, Loránd Barthó, Róbert Papp, Dezső Kelemen, Attila Horváth, Tímea Bencsik, Judit Hohmann, Katalin Veres, Javad Mottaghipisheh & Dezső Csupor 2018. Evidence Supports Tradition: The in Vitro Effects of Roman Chamomile on Smooth Muscles. Frontiers in pharmacology 9, 323

Ecotoxicology

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Concern Reference
toxic to aquatic life with long lasting effectsEuropean Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productIJT 18(S3):33-40, 1999
43 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyIJT 18(S3):33-40, 1999

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List

Data Sources

  • IJT 18(S3):33-40, 1999
  • Laura Cuzzolin, Francesco Francini-Pesenti, Giovanna Verlato, Marco Joppi, Paola Baldelli & Giuseppina Benoni 2010. Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome. Pharmacoepidemiology and drug safety 19(11), 1151-8.
  • Cosmetic Ingredient Review (CIR) 2015. CIR Assessments. Appears as: listid: CIR-3040; Chemical_Name: Anthemis nobilis flower extract; ; ; Classification: QQQ02, QQQ54;
  • European Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • IJT 36(Suppl 1):57-66, 2017
  • Zsolt Sándor, Loránd Barthó, Róbert Papp, DezsÅ‘ Kelemen, Attila Horváth, Tímea Bencsik, Judit Hohmann, Katalin Veres, Javad Mottaghipisheh & DezsÅ‘ Csupor 2018. Evidence Supports Tradition: The in Vitro Effects of Roman Chamomile on Smooth Muscles. Frontiers in pharmacology 9, 323
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

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