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ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL
Score:
Data: Limited
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Enhanced skin absorption, Use restrictions (low), Neurotoxicity (low), Non-reproductive organ system toxicity (low), and Irritation (skin, eyes, or lungs) (low)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| facial moisturizer/treatment | 47 products |
| moisturizer | 24 products |
| facial cleanser | 22 products |
| serums & essences | 21 products |
| body wash/cleanser | 14 products |
| shampoo | 13 products |
| moisturizer with SPF | 12 products |
| baby lotion | 12 products |
| body oil | 11 products |
| anti-aging | 9 products |
| baby soap | 9 products |
| bath oil/salts/soak | 8 products |
| baby oil | 8 products |
| conditioner | 7 products |
| baby shampoo | 7 products |
| mask | 7 products |
| exfoliant/scrub | 7 products |
| toners/astringents | 6 products |
| body spray | 5 products |
| beach & sport sunscreen | 5 products |
| fragrance for women | 4 products |
| diaper cream | 4 products |
| bubble bath | 4 products |
| baby sunscreen | 4 products |
| lip balm | 4 products |
| makeup remover | 4 products |
| vapor rubs | 4 products |
| baby bubble bath | 3 products |
| hair treatment/serum | 3 products |
| CC cream | 3 products |
| antiperspirant/deodorant | 3 products |
| bar soap | 2 products |
| baby powder | 2 products |
| liquid hand soap | 2 products |
| around-eye cream | 2 products |
| body firming lotion | 2 products |
| facial powder | 2 products |
| makeup primer | 2 products |
| hair spray | 1 products |
| shaving cream | 1 products |
| fragrance for men | 1 products |
| mouthwash | 1 products |
| hand cream | 1 products |
| body powder | 1 products |
| styling gel/lotion | 1 products |
| toothpaste | 1 products |
Enhanced skin absorption
| Concern | Reference |
|---|---|
| Penetration enhancer | IJT 18(S3):33-40, 1999 |
Developmental/reproductive toxicity
| Concern | Reference |
|---|---|
| Weak evidence of possible pregnancy/birth effects associated with chamomile consumption. | Laura Cuzzolin, Francesco Francini-Pesenti, Giovanna Verlato, Marco Joppi, Paola Baldelli & Giuseppina Benoni 2010. Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome. Pharmacoepidemiology and drug safety 19(11), 1151-8. |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| Safe for use when formulated to be non-sensitizing | Cosmetic Ingredient Review (CIR) 2019. CIR Assessments. Appears as: listid: CIR-3041; Chemical_Name: Anthemis nobilis flower oil; ; ; Classification: QQQ02, QQQ54; Notes1: safe for use in cosmetics when formulated to be non-sensitizing |
| Allergic skin reaction observed in human case study. | B C. McGeorge & M. C. Steele. 1991. Allergic contact dermatitis of the nipple from Roman chamomile ointment. Contact dermatitis 24(2), 139-40. |
| May cause an allergic skin reaction. | European Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7 |
Irritation (skin, eyes, or lungs)
| Concern | Reference |
|---|---|
| Causes skin irritation | European Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7 |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| May be fatal if swallowed and enters airways | European Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7 |
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Use restrictions
| Concern | Reference |
|---|---|
| Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | IJT 36(Suppl 1):57-66, 2017 |
Neurotoxicity
| Concern | Reference |
|---|---|
| Inhalation of A. nobilis oil or one of its components elicited behavioral changes in rats. | Yingying Kong, Ting Wang, Rong Wang, Yichuan Ma, Shanshan Song, Juan Liu, Weiwei Hu & Shengtian Li 2017. Inhalation of Roman chamomile essential oil attenuates depressive-like behaviors in Wistar Kyoto rats. Science China. Life sciences 60(6), 647-655. |
Ecotoxicology
| Concern | Reference |
|---|---|
| toxic to aquatic life with long lasting effects | European Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7 |
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Data gaps
| Concern | Reference |
|---|---|
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | IJT 18(S3):33-40, 1999 |
| 7 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Multiple, additive exposure sources
| Concern | Reference |
|---|---|
| Designated as safe for general or specific, limited use in food | FDA Everything Added to Food |
Informational
| Concern | Reference |
|---|---|
| Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - any | IJT 18(S3):33-40, 1999 |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Not suspected to be persistent | Environment Canada Domestic Substance List |
Data Sources
- IJT 18(S3):33-40, 1999
- Laura Cuzzolin, Francesco Francini-Pesenti, Giovanna Verlato, Marco Joppi, Paola Baldelli & Giuseppina Benoni 2010. Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome. Pharmacoepidemiology and drug safety 19(11), 1151-8.
- Cosmetic Ingredient Review (CIR) 2019. CIR Assessments. Appears as: listid: CIR-3041; Chemical_Name: Anthemis nobilis flower oil; ; ; Classification: QQQ02, QQQ54; Notes1: safe for use in cosmetics when formulated to be non-sensitizing
- B C. McGeorge & M. C. Steele. 1991. Allergic contact dermatitis of the nipple from Roman chamomile ointment. Contact dermatitis 24(2), 139-40.
- European Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- IJT 36(Suppl 1):57-66, 2017
- Yingying Kong, Ting Wang, Rong Wang, Yichuan Ma, Shanshan Song, Juan Liu, Weiwei Hu & Shengtian Li 2017. Inhalation of Roman chamomile essential oil attenuates depressive-like behaviors in Wistar Kyoto rats. Science China. Life sciences 60(6), 647-655.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
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