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ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption, Use restrictions (low), Neurotoxicity (low), Non-reproductive organ system toxicity (low), and Irritation (skin, eyes, or lungs) (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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facial moisturizer/treatment47 products
moisturizer24 products
facial cleanser22 products
serums & essences21 products
body wash/cleanser14 products
shampoo13 products
moisturizer with SPF12 products
baby lotion12 products
body oil11 products
anti-aging9 products
baby soap9 products
bath oil/salts/soak8 products
baby oil8 products
conditioner7 products
baby shampoo7 products
mask7 products
exfoliant/scrub7 products
toners/astringents6 products
body spray5 products
beach & sport sunscreen5 products
fragrance for women4 products
diaper cream4 products
bubble bath4 products
baby sunscreen4 products
lip balm4 products
makeup remover4 products
vapor rubs4 products
baby bubble bath3 products
hair treatment/serum3 products
CC cream3 products
antiperspirant/deodorant3 products
bar soap2 products
baby powder2 products
liquid hand soap2 products
around-eye cream2 products
body firming lotion2 products
facial powder2 products
makeup primer2 products
hair spray1 products
shaving cream1 products
fragrance for men1 products
mouthwash1 products
hand cream1 products
body powder1 products
styling gel/lotion1 products
toothpaste1 products

Enhanced skin absorption

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Concern Reference
Penetration enhancerIJT 18(S3):33-40, 1999

Developmental/reproductive toxicity

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Concern Reference
Weak evidence of possible pregnancy/birth effects associated with chamomile consumption.Laura Cuzzolin, Francesco Francini-Pesenti, Giovanna Verlato, Marco Joppi, Paola Baldelli & Giuseppina Benoni 2010. Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome. Pharmacoepidemiology and drug safety 19(11), 1151-8.

Allergies/immunotoxicity

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Concern Reference
Safe for use when formulated to be non-sensitizingCosmetic Ingredient Review (CIR) 2019. CIR Assessments. Appears as: listid: CIR-3041; Chemical_Name: Anthemis nobilis flower oil; ; ; Classification: QQQ02, QQQ54; Notes1: safe for use in cosmetics when formulated to be non-sensitizing
Allergic skin reaction observed in human case study.B C. McGeorge & M. C. Steele. 1991. Allergic contact dermatitis of the nipple from Roman chamomile ointment. Contact dermatitis 24(2), 139-40.
May cause an allergic skin reaction.European Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7

Irritation (skin, eyes, or lungs)

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Concern Reference
Causes skin irritationEuropean Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7

Organ system toxicity (non-reproductive)

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Concern Reference
May be fatal if swallowed and enters airwaysEuropean Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Use restrictions

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Concern Reference
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsIJT 36(Suppl 1):57-66, 2017

Neurotoxicity

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Concern Reference
Inhalation of A. nobilis oil or one of its components elicited behavioral changes in rats.Yingying Kong, Ting Wang, Rong Wang, Yichuan Ma, Shanshan Song, Juan Liu, Weiwei Hu & Shengtian Li 2017. Inhalation of Roman chamomile essential oil attenuates depressive-like behaviors in Wistar Kyoto rats. Science China. Life sciences 60(6), 647-655.

Ecotoxicology

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Concern Reference
toxic to aquatic life with long lasting effectsEuropean Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7
Not suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productIJT 18(S3):33-40, 1999
7 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Everything Added to Food

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - anyIJT 18(S3):33-40, 1999

Persistence and bioaccumulation

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Concern Reference
Not suspected to be persistentEnvironment Canada Domestic Substance List

Data Sources

  • IJT 18(S3):33-40, 1999
  • Laura Cuzzolin, Francesco Francini-Pesenti, Giovanna Verlato, Marco Joppi, Paola Baldelli & Giuseppina Benoni 2010. Use of herbal products among 392 Italian pregnant women: focus on pregnancy outcome. Pharmacoepidemiology and drug safety 19(11), 1151-8.
  • Cosmetic Ingredient Review (CIR) 2019. CIR Assessments. Appears as: listid: CIR-3041; Chemical_Name: Anthemis nobilis flower oil; ; ; Classification: QQQ02, QQQ54; Notes1: safe for use in cosmetics when formulated to be non-sensitizing
  • B C. McGeorge & M. C. Steele. 1991. Allergic contact dermatitis of the nipple from Roman chamomile ointment. Contact dermatitis 24(2), 139-40.
  • European Chemicals Agency (ECHA) 2020. GHS Data from ECHA Website. Appears as: chemical_names: ANTHEMIS NOBILIS (CHAMOMILE) FLOWER OIL; cas_numbers: 8015-92-7
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • IJT 36(Suppl 1):57-66, 2017
  • Yingying Kong, Ting Wang, Rong Wang, Yichuan Ma, Shanshan Song, Juan Liu, Weiwei Hu & Shengtian Li 2017. Inhalation of Roman chamomile essential oil attenuates depressive-like behaviors in Wistar Kyoto rats. Science China. Life sciences 60(6), 647-655.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.

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