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ALUMINUM ZIRCONIUM TETRACHLOROHYDREX GLYCINE COMPLEX
Score:
Data: Limited
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (moderate) and Non-reproductive organ system toxicity (low)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| antiperspirant/deodorant | 35 products |
| antiperspirant/deodorant (men's) | 32 products |
Use restrictions
| Concern | Reference |
|---|---|
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | Canada - Prohibited and Restricted Cosmetics Ingredients |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any | CosIng |
| Use is restricted in Canadian cosmetics. | Health Canada 2011. List of Prohibited and Restricted Cosmetic Ingredients. Canada |
Cancer
| Concern | Reference |
|---|---|
| This study found a relationship between use of antiperspirant product use, breast cancer risk, and aluminum concentration in breast tissue in women. | Caroline Linhart, Nicole Concin, Michael Hubalek, Daniel Egle, Susanne Taucher, Herbert H Lindner, Christopher Exley, Evi M. Morandi, Heribert Talasz & Hanno Ulmer. 2017. Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study. EBioMedicine 21, 79-85. |
| This study found that treating mouse mammary cells with aluminum chloride, at concentrations observed in human breast tissue, formed large metastatic tumors when implanted back into mice. | Stefano J Mandriota, Mirna Tenan, Paolo Ferrari & André-Pascal Sappino. 2016. Aluminium chloride promotes tumorigenesis and metastasis in normal murine mammary gland epithelial cells. International journal of cancer 139(12), 2781-2790. |
| This small (n = 54) epidemiological study found no link between breast cancer and antiperspirant use in women. | Dana K Mirick, Scott Davis & David B. Thomas. 2002. Antiperspirant use and the risk of breast cancer. Journal of the National Cancer Institute 94(20), 1578-80. |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Limited evidence of any toxicity | Klaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull |
Data gaps
| Concern | Reference |
|---|---|
| 0 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Data Sources
- Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
- European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
- Health Canada 2011. List of Prohibited and Restricted Cosmetic Ingredients. Canada
- Caroline Linhart, Nicole Concin, Michael Hubalek, Daniel Egle, Susanne Taucher, Herbert H Lindner, Christopher Exley, Evi M. Morandi, Heribert Talasz & Hanno Ulmer. 2017. Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study. EBioMedicine 21, 79-85.
- Stefano J Mandriota, Mirna Tenan, Paolo Ferrari & André-Pascal Sappino. 2016. Aluminium chloride promotes tumorigenesis and metastasis in normal murine mammary gland epithelial cells. International journal of cancer 139(12), 2781-2790.
- Dana K Mirick, Scott Davis & David B. Thomas. 2002. Antiperspirant use and the risk of breast cancer. Journal of the National Cancer Institute 94(20), 1578-80.
- Klaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
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EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
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