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ALUMINUM ZIRCONIUM TETRACHLOROHYDREX GLYCINE COMPLEX
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (high) and Non-reproductive organ system toxicity (low)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| antiperspirant/deodorant | 57 products |
| antiperspirant/deodorant (men's) | 38 products |
| 1 products |
Use restrictions
| Concern | Reference |
|---|---|
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | U.S. - Ingredients Prohibited and Restricted in Cosmetics by FDA Regulations |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmetics | Canada - Prohibited and Restricted Cosmetics Ingredients |
| Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any | CosIng |
| Use is restricted in Canadian cosmetics. | Health Canada 2011. List of Prohibited and Restricted Cosmetic Ingredients. Canada |
Cancer
| Concern | Reference |
|---|---|
| This study found a relationship between use of antiperspirant product use, breast cancer risk, and aluminum concentration in breast tissue in women. | Caroline Linhart, Nicole Concin, Michael Hubalek, Daniel Egle, Susanne Taucher, Herbert H Lindner, Christopher Exley, Evi M. Morandi, Heribert Talasz & Hanno Ulmer. 2017. Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study. EBioMedicine 21, 79-85. |
| This study found that treating mouse mammary cells with aluminum chloride, at concentrations observed in human breast tissue, formed large metastatic tumors when implanted back into mice. | Stefano J Mandriota, Mirna Tenan, Paolo Ferrari & André-Pascal Sappino. 2016. Aluminium chloride promotes tumorigenesis and metastasis in normal murine mammary gland epithelial cells. International journal of cancer 139(12), 2781-2790. |
| This small (n = 54) epidemiological study found no link between breast cancer and antiperspirant use in women. | Dana K Mirick, Scott Davis & David B. Thomas. 2002. Antiperspirant use and the risk of breast cancer. Journal of the National Cancer Institute 94(20), 1578-80. |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Limited evidence of any toxicity | Klaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull |
Data gaps
| Concern | Reference |
|---|---|
| 0 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Data Sources
- FDA (U.S. Food and Drug Administration), 2006. Ingredients Prohibited and Restricted by FDA Regulations. FDA Center for Food Safety and Applied Nutrition, Office of Cosmetics and Colors. Downloaded from http://www.cfsan.fda.gov/~dms/cos-210.html.
- Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
- European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
- Health Canada 2011. List of Prohibited and Restricted Cosmetic Ingredients. Canada
- Caroline Linhart, Nicole Concin, Michael Hubalek, Daniel Egle, Susanne Taucher, Herbert H Lindner, Christopher Exley, Evi M. Morandi, Heribert Talasz & Hanno Ulmer. 2017. Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study. EBioMedicine 21, 79-85.
- Stefano J Mandriota, Mirna Tenan, Paolo Ferrari & André-Pascal Sappino. 2016. Aluminium chloride promotes tumorigenesis and metastasis in normal murine mammary gland epithelial cells. International journal of cancer 139(12), 2781-2790.
- Dana K Mirick, Scott Davis & David B. Thomas. 2002. Antiperspirant use and the risk of breast cancer. Journal of the National Cancer Institute 94(20), 1578-80.
- Klaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- This ingredient’s score is higher if used in products that are inhalable (e.g., sprays, powders) because of respiratory concerns.
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