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ALUMINUM CHLORIDE

Score:

Data: Fair

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (moderate), Persistence and bioaccumulation (moderate), Non-reproductive organ system toxicity (moderate), and Ecotoxicology (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is MODERATE

Products with this Ingredient

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antiperspirant/deodorant1 products
serums & essences1 products

Allergies/immunotoxicity

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Concern Reference
Asthmagen sensitizer [Asthmagen, sensitizer induced according to Review by the Association of Occupational and Environmental Clinics (AOEC)] AOEC (Association of Occupational and Environmental Clinics) 2012. Asthmagen compilation - AEOC exposures codes.

Persistence and bioaccumulation

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Concern Reference
Persistent or bioaccumulative and moderate to high toxicity concern in humansEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Use restrictions

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Concern Reference
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - Use is restricted in Canadian cosmeticsCanada - Prohibited and Restricted Cosmetics Ingredients

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as expected to be toxic or harmfulEnvironment Canada Domestic Substance List
Limited evidence of any toxicityKlaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull
Classified as a low human health priorityEnvironment Canada Domestic Substance List

Cancer

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Concern Reference
This study found a relationship between use of antiperspirant product use, breast cancer risk, and aluminum concentration in breast tissue in women.Caroline Linhart, Nicole Concin, Michael Hubalek, Daniel Egle, Susanne Taucher, Herbert H Lindner, Christopher Exley, Evi M. Morandi, Heribert Talasz & Hanno Ulmer. 2017. Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study. EBioMedicine 21, 79-85.
This study found that treating mouse mammary cells with aluminum chloride, at concentrations observed in human breast tissue, formed large metastatic tumors when implanted back into mice.Stefano J Mandriota, Mirna Tenan, Paolo Ferrari & André-Pascal Sappino. 2016. Aluminium chloride promotes tumorigenesis and metastasis in normal murine mammary gland epithelial cells. International journal of cancer 139(12), 2781-2790.
This small (n = 54) epidemiological study found no link between breast cancer and antiperspirant use in women.Dana K Mirick, Scott Davis & David B. Thomas. 2002. Antiperspirant use and the risk of breast cancer. Journal of the National Cancer Institute 94(20), 1578-80.

Occupational hazards

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Concern Reference
Single case study detailing occupational hazardsJankovic, J A Screening Method for Occupational Reproductive Health Risk. American Industrial Hygiene Association Journal. 57: 641-649. 1996.

Ecotoxicology

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Concern Reference
Suspected to be an environmental toxin and be persistent or bioaccumulativeEnvironment Canada Domestic Substance List
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Miscellaneous

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Concern Reference
Occupational hazards related to handlingCPS&Q - Classification & Labelling

Data gaps

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Concern Reference
1509 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Data Sources

  • AOEC (Association of Occupational and Environmental Clinics) 2012. Asthmagen compilation - AEOC exposures codes.
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
  • Klaassen, C, M. Amdur and J. Doull (eds.). Casarett and Doull
  • Caroline Linhart, Nicole Concin, Michael Hubalek, Daniel Egle, Susanne Taucher, Herbert H Lindner, Christopher Exley, Evi M. Morandi, Heribert Talasz & Hanno Ulmer. 2017. Use of Underarm Cosmetic Products in Relation to Risk of Breast Cancer: A Case-Control Study. EBioMedicine 21, 79-85.
  • Stefano J Mandriota, Mirna Tenan, Paolo Ferrari & André-Pascal Sappino. 2016. Aluminium chloride promotes tumorigenesis and metastasis in normal murine mammary gland epithelial cells. International journal of cancer 139(12), 2781-2790.
  • Dana K Mirick, Scott Davis & David B. Thomas. 2002. Antiperspirant use and the risk of breast cancer. Journal of the National Cancer Institute 94(20), 1578-80.
  • Jankovic, J A Screening Method for Occupational Reproductive Health Risk. American Industrial Hygiene Association Journal. 57: 641-649. 1996.
  • CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About this Ingredient's Score Range

  • This ingredient’s score is higher if used in products that are inhalable (e.g., sprays, powders) because of respiratory concerns.
  • Products with the EWG VERIFIED mark have met use restrictions and warnings based on EWG review of company data.

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