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ALOE BARBADENSIS (ALOE VERA) LEAF EXTRACT

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (low)

Cancer

Cancer concern is MODERATE

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lipstick213 products
beach & sport sunscreen81 products
facial moisturizer/treatment53 products
foundation53 products
conditioner46 products
lip balm46 products
moisturizer45 products
shampoo42 products
body wash/cleanser36 products
mask34 products
concealer34 products
moisturizer with SPF33 products
baby wipes32 products
lip balm with SPF29 products
serums & essences29 products
eye shadow27 products
makeup remover26 products
facial cleanser24 products
mascara23 products
lip gloss22 products
toners/astringents20 products
bar soap18 products
hair treatment/serum17 products
bronzer/highlighter15 products
lip liner13 products
hand cream12 products
antiperspirant/deodorant12 products
CC cream11 products
hair color and bleaching11 products
makeup primer11 products
exfoliant/scrub10 products
around-eye cream10 products
blush9 products
BB cream9 products
after sun product8 products
hair spray8 products
liquid hand soap8 products
body firming lotion8 products
hair styling aide8 products
baby oil7 products
baby shampoo6 products
baby sunscreen6 products
eye makeup remover6 products
toothpaste5 products
baby powder5 products
antiperspirant/deodorant (men's)5 products
hand sanitizer5 products
beard care5 products
baby lotion4 products
diaper cream4 products
body spray4 products
lip plumper4 products
styling gel/lotion3 products
body oil3 products
facial powder3 products
baby soap3 products
eye liner3 products
shaving cream (men's)3 products
shaving cream3 products
detangler3 products
anti-aging2 products
fragrance for women2 products
glitter2 products
mouthwash2 products
pore strips2 products
1 products
after shave1 products
baby bubble bath1 products
damaged skin treatment1 products
body powder1 products
fragrance for men1 products
beard oil1 products
foot moisturizer1 products
bath oil/salts/soak1 products
bubble bath1 products
vapor rubs1 products
tanning oil1 products
styling mousse/foam1 products
cuticle treatment1 products

Cancer

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Concern Reference
Possible human carcinogenIARC (International Agency for Research on Cancer) 2016. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-113.
Cancer - strong evidenceNTP (National Toxicology Program) 2013. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF A NONDECOLORIZED WHOLE LEAF EXTRACT OF ALOE BARBADENSIS MILLER (ALOE VERA) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES). NIH Publication No. 13-5910.
Limited or incomplete evidence of cancer according to safety/hazard data – scientific review cannot classify as human carcinogen due to data gapsNTP (National Toxicology Program) 2010. NTP TECHNICAL REPORT ON THE PHOTOCOCARCINOGENESIS STUDY OF ALOE VERA in SKH-1 MICE. NIH Publication No. 10-5894

Developmental/reproductive toxicity

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Concern Reference
3 month rat study produced significant sperm damageCIR (2006) 2006 CIR Compendium. Washington, Cosmetic Ingredient Review.

Use restrictions

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Concern Reference
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsIJT 26(S2):1-50, 2007

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productIJT 26(S2):1-50, 2007
Missing safety data noted by cosmetic industry reviewIJT 26(S2):1-50, 2007
151 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Determined safe for use in cosmetics up to a specified concentration limitIJT 26(S2):1-50, 2007

Data Sources

  • IARC (International Agency for Research on Cancer) 2016. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-113.
  • NTP (National Toxicology Program) 2013. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF A NONDECOLORIZED WHOLE LEAF EXTRACT OF ALOE BARBADENSIS MILLER (ALOE VERA) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES). NIH Publication No. 13-5910.
  • NTP (National Toxicology Program) 2010. NTP TECHNICAL REPORT ON THE PHOTOCOCARCINOGENESIS STUDY OF ALOE VERA in SKH-1 MICE. NIH Publication No. 10-5894
  • CIR (2006) 2006 CIR Compendium. Washington, Cosmetic Ingredient Review.
  • IJT 26(S2):1-50, 2007
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

About this Ingredient's Score Range

  • This ingredient’s score is higher if a product likely contains the non-decolorized whole leaf aloe vera, which is known to cause cancer. The score will be lower if the decolorized version of the ingredient is used.

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