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ALOE BARBADENSIS (ALOE VERA) LEAF EXTRACT

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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lipstick145 products
beach & sport sunscreen82 products
facial moisturizer/treatment40 products
lip balm31 products
moisturizer28 products
serums & essences28 products
foundation27 products
lip balm with SPF27 products
facial cleanser27 products
concealer24 products
moisturizer with SPF22 products
toners/astringents21 products
mask19 products
eye shadow17 products
bronzer/highlighter15 products
lip gloss14 products
shampoo13 products
body wash/cleanser13 products
conditioner12 products
makeup remover12 products
bar soap11 products
hair color and bleaching11 products
antiperspirant/deodorant10 products
blush9 products
baby wipes8 products
mascara8 products
around-eye cream7 products
hair treatment/serum7 products
exfoliant/scrub6 products
hand cream6 products
baby shampoo6 products
makeup primer6 products
baby soap5 products
toothpaste5 products
body spray4 products
baby sunscreen4 products
BB cream4 products
liquid hand soap4 products
hair spray3 products
makeup with SPF3 products
lip liner3 products
CC cream3 products
shaving cream2 products
baby powder2 products
styling gel/lotion2 products
baby oil2 products
bath oil/salts/soak2 products
shaving cream (men's)2 products
baby bubble bath2 products
detangler2 products
eye liner2 products
facial powder2 products
hand sanitizer2 products
bubble bath1 products
lip plumper1 products
body oil1 products
after sun product1 products
antiperspirant/deodorant (men's)1 products
vapor rubs1 products
diaper cream1 products
eye makeup remover1 products
baby lotion1 products
fragrance for men1 products

Cancer

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Concern Reference
Possible human carcinogenIARC (International Agency for Research on Cancer) 2016. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-113.
Cancer - strong evidenceNTP (National Toxicology Program) 2013. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF A NONDECOLORIZED WHOLE LEAF EXTRACT OF ALOE BARBADENSIS MILLER (ALOE VERA) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES). NIH Publication No. 13-5910.
Limited or incomplete evidence of cancer according to safety/hazard data – scientific review cannot classify as human carcinogen due to data gapsNTP (National Toxicology Program) 2010. NTP TECHNICAL REPORT ON THE PHOTOCOCARCINOGENESIS STUDY OF ALOE VERA in SKH-1 MICE. NIH Publication No. 10-5894

Use restrictions

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Concern Reference
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsIJT 26(S2):1-50, 2007

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productIJT 26(S2):1-50, 2007
Missing safety data noted by cosmetic industry reviewIJT 26(S2):1-50, 2007
151 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Determined safe for use in cosmetics up to a specified concentration limitIJT 26(S2):1-50, 2007

Data Sources

  • IARC (International Agency for Research on Cancer) 2016. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-113.
  • NTP (National Toxicology Program) 2013. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF A NONDECOLORIZED WHOLE LEAF EXTRACT OF ALOE BARBADENSIS MILLER (ALOE VERA) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES). NIH Publication No. 13-5910.
  • NTP (National Toxicology Program) 2010. NTP TECHNICAL REPORT ON THE PHOTOCOCARCINOGENESIS STUDY OF ALOE VERA in SKH-1 MICE. NIH Publication No. 10-5894
  • IJT 26(S2):1-50, 2007
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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