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ALOE BARBADENSIS (ALOE VERA) LEAF JUICE

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (low)

Cancer

Cancer concern is MODERATE

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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conditioner276 products
shampoo271 products
moisturizer263 products
beach & sport sunscreen224 products
facial moisturizer/treatment213 products
body wash/cleanser191 products
mask161 products
facial cleanser126 products
liquid hand soap123 products
moisturizer with SPF114 products
antiperspirant/deodorant84 products
toners/astringents78 products
serums & essences75 products
hair treatment/serum74 products
body firming lotion73 products
foundation72 products
shaving cream64 products
hair styling aide61 products
exfoliant/scrub54 products
toothpaste49 products
hand sanitizer49 products
makeup remover48 products
after sun product47 products
hand cream45 products
baby lotion35 products
around-eye cream32 products
bar soap30 products
baby shampoo28 products
baby soap26 products
hair color and bleaching26 products
mouthwash22 products
bubble bath22 products
styling gel/lotion21 products
baby wipes21 products
baby sunscreen21 products
anti-aging20 products
detangler20 products
mascara20 products
makeup primer19 products
hair spray18 products
shaving cream (men's)17 products
CC cream17 products
BB cream16 products
antiperspirant/deodorant (men's)14 products
foot moisturizer13 products
after shave13 products
bath oil/salts/soak13 products
brow liner13 products
baby bubble bath12 products
12 products
beard care11 products
sunless tanning8 products
concealer8 products
eye makeup remover8 products
lip balm8 products
diaper cream6 products
eye liner6 products
lipstick5 products
oil controller5 products
muscle/joint soreness4 products
body spray4 products
eye shadow4 products
styling mousse/foam4 products
blush4 products
beard cleanser4 products
fragrance for women3 products
baby toothpaste3 products
baby oil3 products
foot odor control2 products
body oil2 products
tooth whitening2 products
body powder2 products
other eye makeup2 products
damaged skin treatment2 products
facial powder1 products
polish remover1 products
bronzer/highlighter1 products
other men's products1 products
depilatory1 products
tanning oil1 products
hair relaxer1 products
lip balm with SPF1 products
lip plumper1 products

Cancer

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Concern Reference
Possible human carcinogenIARC (International Agency for Research on Cancer) 2016. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-113.
Cancer - strong evidenceNTP (National Toxicology Program) 2013. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF A NONDECOLORIZED WHOLE LEAF EXTRACT OF ALOE BARBADENSIS MILLER (ALOE VERA) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES). NIH Publication No. 13-5910.
Limited or incomplete evidence of cancer according to safety/hazard data – scientific review cannot classify as human carcinogen due to data gapsNTP (National Toxicology Program) 2010. NTP TECHNICAL REPORT ON THE PHOTOCOCARCINOGENESIS STUDY OF ALOE VERA in SKH-1 MICE. NIH Publication No. 10-5894

Developmental/reproductive toxicity

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Concern Reference
3 month rat study produced significant sperm damageCIR (2006) 2006 CIR Compendium. Washington, Cosmetic Ingredient Review.

Use restrictions

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Concern Reference
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsIJT 26(S2):1-50, 2007

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productIJT 26(S2):1-50, 2007
Missing safety data noted by cosmetic industry reviewIJT 26(S2):1-50, 2007
103 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Determined safe for use in cosmetics up to a specified concentration limitIJT 26(S2):1-50, 2007

Data Sources

  • IARC (International Agency for Research on Cancer) 2016. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-113.
  • NTP (National Toxicology Program) 2013. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF A NONDECOLORIZED WHOLE LEAF EXTRACT OF ALOE BARBADENSIS MILLER (ALOE VERA) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES). NIH Publication No. 13-5910.
  • NTP (National Toxicology Program) 2010. NTP TECHNICAL REPORT ON THE PHOTOCOCARCINOGENESIS STUDY OF ALOE VERA in SKH-1 MICE. NIH Publication No. 10-5894
  • CIR (2006) 2006 CIR Compendium. Washington, Cosmetic Ingredient Review.
  • IJT 26(S2):1-50, 2007
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.

About this Ingredient's Score Range

  • This ingredient’s score is higher if a product likely contains the non-decolorized whole leaf aloe vera, which is known to cause cancer. The score will be lower if the decolorized version of the ingredient is used.

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