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ALOE BARBADENSIS (ALOE VERA) LEAF JUICE

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Use restrictions (low)

Cancer

Cancer concern is MODERATE

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is LOW

Products with this Ingredient

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moisturizer236 products
shampoo236 products
conditioner224 products
facial moisturizer/treatment207 products
beach & sport sunscreen192 products
body wash/cleanser177 products
mask151 products
facial cleanser119 products
moisturizer with SPF107 products
liquid hand soap89 products
foundation69 products
antiperspirant/deodorant66 products
serums & essences66 products
toners/astringents64 products
shaving cream50 products
toothpaste48 products
makeup remover46 products
exfoliant/scrub45 products
baby lotion39 products
hair styling aide39 products
hand cream38 products
hair treatment/serum37 products
body firming lotion36 products
around-eye cream31 products
hand sanitizer29 products
after sun product28 products
hair color and bleaching26 products
mouthwash25 products
bubble bath25 products
baby shampoo22 products
bar soap22 products
baby soap21 products
brow liner17 products
mascara17 products
baby sunscreen17 products
makeup primer15 products
concealer15 products
BB cream15 products
CC cream15 products
shaving cream (men's)15 products
anti-aging14 products
styling gel/lotion14 products
detangler13 products
baby bubble bath12 products
baby wipes11 products
after shave11 products
sunless tanning10 products
foot moisturizer10 products
bath oil/salts/soak10 products
hair spray9 products
antiperspirant/deodorant (men's)9 products
eye liner9 products
body spray6 products
oil controller6 products
5 products
lip balm5 products
eye makeup remover4 products
diaper cream4 products
blush4 products
eye shadow4 products
lipstick4 products
muscle/joint soreness3 products
beard care3 products
tooth whitening3 products
baby toothpaste3 products
other men's products3 products
makeup with SPF2 products
other eye makeup2 products
damaged skin treatment2 products
depilatory2 products
styling mousse/foam2 products
baby oil2 products
facial powder1 products
polish remover1 products
bronzer/highlighter1 products
lip balm with SPF1 products
lip plumper1 products
body oil1 products
hair relaxer1 products
beard cleanser1 products

Cancer

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Concern Reference
Possible human carcinogenIARC (International Agency for Research on Cancer) 2016. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-113.
Cancer - strong evidenceNTP (National Toxicology Program) 2013. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF A NONDECOLORIZED WHOLE LEAF EXTRACT OF ALOE BARBADENSIS MILLER (ALOE VERA) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES). NIH Publication No. 13-5910.
Limited or incomplete evidence of cancer according to safety/hazard data – scientific review cannot classify as human carcinogen due to data gapsNTP (National Toxicology Program) 2010. NTP TECHNICAL REPORT ON THE PHOTOCOCARCINOGENESIS STUDY OF ALOE VERA in SKH-1 MICE. NIH Publication No. 10-5894

Developmental/reproductive toxicity

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Concern Reference
3 month rat study produced significant sperm damageCIR (2006) 2006 CIR Compendium. Washington, Cosmetic Ingredient Review.

Use restrictions

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Concern Reference
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualificationsIJT 26(S2):1-50, 2007

Data gaps

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Concern Reference
Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in productIJT 26(S2):1-50, 2007
Missing safety data noted by cosmetic industry reviewIJT 26(S2):1-50, 2007
103 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Multiple, additive exposure sources

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Concern Reference
Designated as safe for general or specific, limited use in foodFDA Food Additive Status

Informational

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Concern Reference
Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Determined safe for use in cosmetics up to a specified concentration limitIJT 26(S2):1-50, 2007

Data Sources

  • IARC (International Agency for Research on Cancer) 2016. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-113.
  • NTP (National Toxicology Program) 2013. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF A NONDECOLORIZED WHOLE LEAF EXTRACT OF ALOE BARBADENSIS MILLER (ALOE VERA) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES). NIH Publication No. 13-5910.
  • NTP (National Toxicology Program) 2010. NTP TECHNICAL REPORT ON THE PHOTOCOCARCINOGENESIS STUDY OF ALOE VERA in SKH-1 MICE. NIH Publication No. 10-5894
  • CIR (2006) 2006 CIR Compendium. Washington, Cosmetic Ingredient Review.
  • IJT 26(S2):1-50, 2007
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
  • FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.

About this Ingredient's Score Range

  • This ingredient’s score is higher if a product likely contains the non-decolorized whole leaf aloe vera, which is known to cause cancer. The score will be lower if the decolorized version of the ingredient is used.

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