IMAGE SOURCE: PubChem
Other ConcernsUse restrictions (high), Non-reproductive organ system toxicity (high), Irritation (skin, eyes, or lungs) (high), and Occupational hazards (high)
SYNONYMS2PROPENAMIDE and ACRYLAMIDE
Unacceptable: EWG VERIFIED products cannot contain this ingredient
See how this product scores for common concerns.
MODERATEAllergies & Immunotoxicity
MODERATEDevelopmental and Reproductive Toxicity
- DATA SOURCES
Products with this Ingredient
|muscle/joint soreness||2 products|
|facial moisturizer/treatment||1 products|
Organ system toxicity (non-reproductive)
|Known human respiratory toxicant||EPA Hazardous Air Pollutants|
|Classified as a high human health priority||Environment Canada Domestic Substance List|
|Classified as expected to be toxic or harmful||Environment Canada Domestic Substance List|
|Classified as toxic or harmful||CPS&Q - Classification & Labelling|
|One or more animal studies show classified as toxic effects at moderate doses (low dose studies may be unavailable for this ingredient)||EPA Toxic Release Inventory PBTs|
|reproductive - weight of evidence unknown/unassessed/unreview: published lit review or major tox study||National Library of Medicine HazMap|
|Violation of government restrictions - Banned or found unsafe for use in cosmetics||Canada - Prohibited and Restricted Cosmetics Ingredients|
|Determined safe for use in cosmetics, subject to concentration or use limitations - any||Open scientific literature|
Irritation (skin, eyes, or lungs)
|Classified as irritant||CPS&Q - Classification & Labelling|
|Allowed workplace exposures restricted to low doses||CPS&Q - Classification & Labelling|
|Possible human carcinogen||Int'l Agency for Research on Cancer (IARC) - Carcinogens|
|Possible human carcinogen||EPA Integrated Risk Information System (IRIS)|
|Possible human carcinogen||NTP Report on Carcinogens, 11th Edition|
|Possible human carcinogen||California EPA Proposition 65|
|Possible human carcinogen||CPS&Q - Classification & Labelling|
|Limited evidence of carcinogenicity||Amer Conf of Gov't Industrial Hygienists - Carcinogens|
|Limited evidence of carcinogenicity||NIOSH Occupational Carcinogens|
|Possible mutagen||CPS&Q - Classification & Labelling|
|Cancer - limited evidence||Silent Spring's Mammary Carcinogens Reviews Database|
|Possible human developmental toxicant||California EPA Proposition 65|
|Limited evidence of reproductive toxicity||National Library of Medicine HazMap|
|Limited evidence of developmental toxicity||CPS&Q - Classification & Labelling|
|Limited evidence of reproductive toxicity||Scorecard.org Toxicity Information|
|Possible human any toxicant or allergen||Open scientific literature|
|Limited evidence of immune system toxicity or allergies||CPS&Q - Classification & Labelling|
|Limited evidence of immune system toxicity or allergies||National Library of Medicine HazMap|
|Limited evidence of any toxicity or allergies||Open scientific literature|
|Wildlife and environmental toxicity||Open scientific literature|
|Suspected to be an environmental toxin||Environment Canada Domestic Substance List|
|nervous system - weight of evidence unknown/unassessed/unreview: published lit review or major tox study||National Library of Medicine HazMap|
Persistence and bioaccumulation
|Not suspected to be bioaccumulative||Environment Canada Domestic Substance List|
|Not suspected to be persistent||Environment Canada Domestic Substance List|
|9099 studies in PubMed science library may include information on the toxicity of this chemical||NLM PubMed|
- EPA (U.S. Environmental Protection Agency). 2005. Office of Air. The 112(b)1 Hazardous Air Pollutants List (as modified). Last modified: 12 Dec 2005.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
- EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule.
- NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents.
- Health Canada. 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's Cosmetic Ingredient Hotlist. March 2007.
- Open scientific/peer reviewed literature
- IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
- EPA (U.S. Environmental Protection Agency). 2008. Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986-2005 guidelines.
- NTP (National Toxicology Program). 2005. Report on Carcinogens, Eleventh Edition; U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program.
- California EPA (California Environmental Protection Agency). 9/2008. Office of Environmental Health Hazard Assessment. Safe Drinking Water and Toxic Enforcement Act of 1986. Chemicals known to the State to cause cancer or reproductive toxicity.
- ACGIH (American Conference of Governmental Industrial Hygienists) 2008. ACGIH cancer classification system. www.acgih.org.
- NIOSH (National Institute for Occupational Safety and Health). 2006. NIOSH Carcinogens List (Potential occupational carcinogens). http://www.cdc.gov/niosh/npotocca.html.
- Rudel RA, KR Attfield, JN Schifano and JG Brody. Chemicals Causing Mammary Gland Tumors in Animals Signal New Directions for Epidemiology, Chemicals Testing, and Risk Assessment for Breast Cancer Prevention. CANCER Supplement. 2007 Jun 15;109(12):2635-2666.
- ED (Environmental Defense). 2006. Scorecard _ The Pollution Information Site. http://www.scorecard.org.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.
Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.HOW WE DETERMINE SCORES
The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED™ mark means a product meets EWG’s strictest criteria for transparency and health.
The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.