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Acid Yellow 3 (Uncertified D&C Yellow No. 10)
Score:
Data: Fair
- Other Concerns
- Functions
- About the Chemical
- Synonyms
-
Use restrictions (high), Neurotoxicity (low), Endocrine disruption (low), Irritation (skin, eyes, or lungs) (low), and Contamination concerns (high)
Cancer 
Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments.
Developmental & Reproductive Toxicity
Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children.
Allergies & Immunotoxicity
Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body.
Products with this Ingredient
| bath oil/salts/soak | 1 products |
Contamination concerns
Use restrictions
| Concern | Reference |
|---|---|
| Violation of government restrictions - Banned or found unsafe for use in cosmetics | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Allergies/immunotoxicity
| Concern | Reference |
|---|---|
| EFSA reports that Yellow 10 intolerance/sensitivity has been reported in humans. | European Food Safety Authority (EFSA) 2009. Scientific Opinion on the reâ€evaluation of Quinoline Yellow (E 104) as a food additive. EFSA Journal 7(11), 1329. |
Neurotoxicity
| Concern | Reference |
|---|---|
| EFSA concludes there is limited evidence that Yellow 10 in a mixture with other synthetic colours and sodium benzoate has a "small and statistically significant effect on activity and attention in children selected from the general population". | European Food Safety Authority (EFSA) 2009. Scientific Opinion on the reâ€evaluation of Quinoline Yellow (E 104) as a food additive. EFSA Journal 7(11), 1329. |
Irritation (skin, eyes, or lungs)
| Concern | Reference |
|---|---|
| SCCS notes there is limited evidence of skin and eye irritation. | European Commission, Scientific Committee on Consumer Safety (SCCS) 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 3. |
Cancer
| Concern | Reference |
|---|---|
| A peer-reviewed study reports in vitro genotoxicity. | Farah Maria Drumond Chequer, Vinícius de Paula Venâncio, Maíra Rocha de Souza Prado, Luiz Raimundo Campos da Silva e Cunha Junior, Thiago Mescoloto Lizier, Maria Valnice Boldrin Zanoni, Rommel Rodríguez Burbano, Maria Lourdes Pires Bianchi & Lusânia Maria Greggi Antunes 2015. The cosmetic dye quinoline yellow causes DNA damage in vitro. Mutation research. Genetic toxicology and environmental mutagenesis 777, 54-61. |
Developmental/reproductive toxicity
| Concern | Reference |
|---|---|
| SCCS reports that developmental effects have been observed in animal tests. | European Commission, Scientific Committee on Consumer Safety (SCCS) 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 3. |
Endocrine disruption
| Concern | Reference |
|---|---|
| Evidence of endocrine activity from cellular assays. | National Toxicology Program (NTP) 2015. EWG Toxcast Analysis. Appears as: CAS: 8004-92-0; Chemical_Name: C.I. Acid yellow 3 disodium salt |
Data gaps
| Concern | Reference |
|---|---|
| 57 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
| Concern | Reference |
|---|---|
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Informational
| Concern | Reference |
|---|---|
| Color Additives - Batch Certified by the U.S. Food and Drug Administration | Personal Care Products Council 2015. International Cosmetic Ingredient Dictionary and Handbook. Appears as: listid: FCOLOR-333; Chemical_Name: Yellow 10; ; |
Organ system toxicity (non-reproductive)
| Concern | Reference |
|---|---|
| Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
| Classified as a low human health priority | Environment Canada Domestic Substance List |
Persistence and bioaccumulation
| Concern | Reference |
|---|---|
| Not suspected to be persistent | Environment Canada Domestic Substance List |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Data Sources
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
- European Food Safety Authority (EFSA) 2009. Scientific Opinion on the reâ€evaluation of Quinoline Yellow (E 104) as a food additive. EFSA Journal 7(11), 1329.
- European Food Safety Authority (EFSA) 2009. Scientific Opinion on the reâ€evaluation of Quinoline Yellow (E 104) as a food additive. EFSA Journal 7(11), 1329.
- European Commission, Scientific Committee on Consumer Safety (SCCS) 2004. OPINION OF THE SCIENTIFIC COMMITTEE ON COSMETIC PRODUCTS AND NON-FOOD PRODUCTS INTENDED FOR CONSUMERS Concerning Acid Yellow 3.
- Farah Maria Drumond Chequer, Vinícius de Paula Venâncio, Maíra Rocha de Souza Prado, Luiz Raimundo Campos da Silva e Cunha Junior, Thiago Mescoloto Lizier, Maria Valnice Boldrin Zanoni, Rommel Rodríguez Burbano, Maria Lourdes Pires Bianchi & Lusânia Maria Greggi Antunes 2015. The cosmetic dye quinoline yellow causes DNA damage in vitro. Mutation research. Genetic toxicology and environmental mutagenesis 777, 54-61.
- National Toxicology Program (NTP) 2015. EWG Toxcast Analysis. Appears as: CAS: 8004-92-0; Chemical_Name: C.I. Acid yellow 3 disodium salt
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- Personal Care Products Council 2015. International Cosmetic Ingredient Dictionary and Handbook. Appears as: listid: FCOLOR-333; Chemical_Name: Yellow 10; ;
- Products with the EWG VERIFIED mark have met the program’s impurity and use restrictions based on EWG's review of the company's data.
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EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Learn more | Legal Disclaimer
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Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Learn more | Legal Disclaimer
