Other Concerns
Use restrictions (high) and Persistence and bioaccumulation (moderate)SYNONYMS
Unacceptable
Unacceptable: EWG VERIFIED products cannot contain this ingredient
2-Amino-6-Chloro-4-Nitrophenol is a substituted aromatic compound.
Common concerns
See how this product scores for common concerns.
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MODERATECancer
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MODERATEAllergies & Immunotoxicity
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LOWDevelopmental and Reproductive Toxicity
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HIGHUse Restrictions
Ingredient concerns
- CONCERNS
- DATA SOURCES
Products with this Ingredient
hair color and bleaching | 32 products |
hair treatment/serum | 1 products |
mask | 1 products |
Use restrictions
CONCERN | REFERENCE |
---|---|
Violation of government restrictions - Restricted in cosmetics; use, concentration, or manufacturing restrictions - any | Open scientific literature |
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any | Open scientific literature |
Restricted in cosmetics (recommendations or requirements) - use, concentration, or manufacturing restrictions - any | CosIng |
Recommended restricted in cosmetics - use, concentration, or manufacturing restrictions - Product type restrictions or differences noted in safety assessment by industry panel | Cosmetic Ingredient Review Assessments |
Determined safe for use in cosmetics, subject to concentration or use limitations - any | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications | Cosmetic Ingredient Review Assessments |
Allergies/immunotoxicity
CONCERN | REFERENCE |
---|---|
Human skin toxicant or allergen - strong evidence | Cosmetic Ingredient Review Assessments |
Limited evidence of any toxicity or allergies | Open scientific literature |
Persistence and bioaccumulation
CONCERN | REFERENCE |
---|---|
Persistent or bioaccumulative and moderate to high toxicity concern in humans | Open scientific literature |
Not suspected to be persistent | Environment Canada Domestic Substance List |
Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Cancer
CONCERN | REFERENCE |
---|---|
Limited evidence of carcinogenicity | Open scientific literature |
Cancer - limited evidence | Cosmetic Ingredient Review Assessments |
Cancer - limited evidence | CTFA International Cosmetic Ingredient Dictionary and Handbook |
Data gaps
CONCERN | REFERENCE |
---|---|
Considered safe based on assumption of low absorption | Cosmetic Ingredient Review Assessments |
Insufficient data to determine safety | Cosmetic Ingredient Review Assessments |
1 studies in PubMed science library may include information on the toxicity of this chemical | NLM PubMed |
Ecotoxicology
CONCERN | REFERENCE |
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Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Organ system toxicity (non-reproductive)
CONCERN | REFERENCE |
---|---|
Classified as not expected to be potentially toxic or harmful | Environment Canada Domestic Substance List |
Informational
CONCERN | REFERENCE |
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Industry or government recommendations for safe use: restrictions on concentration, impurities, product types, or manufacturing methods - Determined safe for use in cosmetics up to a specified concentration limit | Cosmetic Ingredient Review Assessments |
- Open scientific/peer reviewed literature
- European Commission. 2013. Cosing, the European Commission database with information on cosmetic substances and ingredients. Accessed on March 1, 2013 at http://ec.europa.eu/consumers/cosmetics/cosing/ .
- CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
- CTFA (Cosmetic, Toiletry and Fragrance Association). 2006. International Cosmetic Ingredient Dictionary and Handbook, 11th Edition. Color Additive Information. Washington, DC.
- EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
- NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.
Understanding scores
Cosmetics and personal care products are not required to be tested for safety before being allowed on the market. The Skin Deep® scoring system was designed to help the public understand whether a product is safe to use or whether it contains ingredients of concern.
Every product and ingredient in Skin Deep gets a two-part score – one for hazard and one for data availability. The safest products score well by both measures, with a low hazard rating and a fair or better data availability rating.
HOW WE DETERMINE SCORESHazard score
The Skin Deep ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. The EWG VERIFIED® mark means a product meets EWG’s strictest criteria for transparency and health.
Data availability
The Skin Deep data availability rating reflects the number of scientific studies about the product or ingredient in the published scientific literature.