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GALAXOLIDE

Score:

Data: Limited

  • Other Concerns
  • Functions
  • About the Chemical
  • Synonyms
  • Enhanced skin absorption, Endocrine disruption (moderate), Persistence and bioaccumulation (moderate), and Ecotoxicology (low)

Cancer

Cancer concern is LOW

Developmental & Reproductive Toxicity

Developmental & reproductive toxicity concern is LOW

Allergies & Immunotoxicity

Allergies & immunotoxicity concern is HIGH

Products with this Ingredient

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facial moisturizer/treatment1 products
antiperspirant/deodorant1 products

Enhanced skin absorption

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Concern Reference
Penetration enhancerCalifornia Environmental Contaminant Biomonitoring Program 2013. Synthetic Polycyclic Musks Materials for November 14, 2013 Meeting of Scientific Guidance Panel (SGP) Biomonitoring California.

Allergies/immunotoxicity

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Concern Reference
The European Commission's Scientific Committee on Consumer Safety reports this substance is an established contact allergen in humans.EU Cosmetics Directive 2013. Opinion on Frangrance allergens in cosmetics (2011). Appears as: name: HEXAMETHYLINDANOPYRAN; CAS: 1222-05-5

Persistence and bioaccumulation

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Concern Reference
Persistent, bioaccumulative in wildlifeEmerging PBTs from peer-reviewed literature
Not suspected to be persistentEnvironment Canada Domestic Substance List
Not suspected to be bioaccumulativeEnvironment Canada Domestic Substance List

Endocrine disruption

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Concern Reference
The California Biomonitoring Program reports synthetic polycyclic musks as possible endocrine disruptorsCalifornia Environmental Contaminant Biomonitoring Program 2013. Synthetic Polycyclic Musks Materials for November 14, 2013 Meeting of Scientific Guidance Panel (SGP) Biomonitoring California.
One or more studies show moderate endocrine disruptionCalifornia Environmental Contaminant Biomonitoring Program 2013. Synthetic Polycyclic Musks Materials for November 14, 2013 Meeting of Scientific Guidance Panel (SGP) Biomonitoring California.
Galaxolide (HHCB) was shown to have a weak estrogenic activity in assays with estrogen receptor alpha in vitro.Seinen W, Lemmen JG, Pieters RH, Verbruggen EM, VanderBurg B 1999. AHTN and HHCB show weak estrogenic – but no uterotrophic activity. Toxicol. Lett. 111(1-2): 161–168.

Ecotoxicology

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Concern Reference
Wildlife and environmental toxicityCPS&Q - Classification & Labelling
Suspected to be an environmental toxinEnvironment Canada Domestic Substance List

Data gaps

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Concern Reference
239 studies in PubMed science library may include information on the toxicity of this chemicalNLM PubMed

Organ system toxicity (non-reproductive)

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Concern Reference
Classified as not expected to be potentially toxic or harmfulEnvironment Canada Domestic Substance List

Data Sources

  • California Environmental Contaminant Biomonitoring Program 2013. Synthetic Polycyclic Musks Materials for November 14, 2013 Meeting of Scientific Guidance Panel (SGP) Biomonitoring California.
  • EU Cosmetics Directive 2013. Opinion on Frangrance allergens in cosmetics (2011). Appears as: name: HEXAMETHYLINDANOPYRAN; CAS: 1222-05-5
  • Emerging PBTs from peer-reviewed literature
  • EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
  • Seinen W, Lemmen JG, Pieters RH, Verbruggen EM, VanderBurg B 1999. AHTN and HHCB show weak estrogenic – but no uterotrophic activity. Toxicol. Lett. 111(1-2): 161–168.
  • CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP.
  • NLM (National Library of Medicine). 2012. PubMed online scientific bibliography data. http://www.pubmed.gov.

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