chemical information
CAS RN:

52663-69-1

Chemical Class:

Polychlorinated biphenyl (PCB)

Chemical SubClass

Hepta-PCB

Manufacturing/Use Status

banned for use/manufacture in the U.S.

Found in these people:

Sara Corbett, Baby #5, Baby #6, Baby #7, Baby #9, Baby #3, Baby #1, Baby #4, Baby #10, Baby #2, Baby #8, Monique Harden, Kathy Fowler, Lucy Waletsky, Anonymous Adult 1, Davis Baltz, Charlotte Brody, Bill Moyers, Lexi Rome, U.S. Representative Louise Slaughter, Andrea Martin, Michael Lerner, Sharyle Patton, Cord Blood Sample 20, Cord Blood Sample 11, Cord Blood Sample 12, Cord Blood Sample 13, Cord Blood Sample 14, Cord Blood Sample 15, Cord Blood Sample 16, Cord Blood Sample 17, Cord Blood Sample 18, Cord Blood Sample 19

Found in these locations:

NY, USA; New Orleans, LA; Rockville, MD; Pleasantville, NY; Berkeley, CA; Round Hill, VA; NJ, USA; Mill Valley, CA; Upstate New York, NY; Sausalito, CA; Bolinas, CA

Exposure routes:

Banned industrial insulators and lubricants. Residual environmental contamination results in continued exposures.


Summary

Laboratory animals. In animal studies, PCBs cause a wide variety of effects including liver and thyroid tumors; kidney, gastrointestinal, immune, urinary tract, and reproductive toxicity; altered lipid and carbohydrate metabolism; nail and nail bed changes; reduced fertility and birth defects. Specific birth defects include reproductive tract and skeletal abnormalities. PCBs are endocrine disruptors because they alter thyroid and adrenal hormone levels and function. PCBs cause significant neurotoxicity, including decreased exploratory behavior, learning, spatial and non-spatial discrimination, auditory deficits and altered levels of brain neurotransmitters (dopamine and serotonin) (ATSDR 2000b).

Humans. The effects of PCBs have been studied in humans who were exposed through diet, work, and industrial accidents. PCBs are reasonably anticipated to be human carcinogen (NTP 2002). They are associated with skin, liver, biliary tract, and intestinal cancers. Other effects of PCBs include respiratory effects, gastrointestinal damage (nausea, vomiting, abdominal pain), eye irritation, increased susceptibility to infection, and hypothyroidism (ATSDR 2000b, Persky, et al. 2001). Other possible health effects associated with PCB exposure are menstrual irregularities and decreased fertility in women. Inconsistent associations have been noted with non-Hodgkin's lymphoma, breast cancer, cardiovascular disease, sperm and fertility in males, low birth weight and head circumference (ATSDR 2000b). PCB exposure in the womb or during lactation is also associated with decreased IQ and impaired psychomotor development, decreased immune function, altered liver enzyme and lipid levels, and skin disease (chloracne) (ATSDR 2000b).


PCB-183

In polychlorinated biphenyl (PCB) family of chemicals - banned industrial insulators and lubricants; cause cancer and nervous system problems.

PCB-183 has been found in 34 of the 35 people tested in EWG/Commonweal studies. It has also been found in 759 of the 4,821 people tested in CDC biomonitoring studies.


Top health concerns for PCB-183 (References)

health concern or target organ weight of evidence
Brain and nervous systemunknown
Immune system (including sensitization and allergies)limited


Results for PCB-183

This chemical was found to co-elute with PCB-185.


in blood serum (lipid weight)

Showing results from San Francisco Reporter, EWG/Commonweal Study #4, industrial chemicals and pesticides in cord blood, Pollution in Minority Newborns, EWG Study #8, chemicals in mother and 2 children, EWG/Commonweal Study #1, industrial chemicals and pesticides in adults, EWG Study #3, industrial chemicals and pesticides in adults

EWG/Commonweal results

  • geometric mean: 0.59 ng/g (lipid weight) in blood serum
  • found in 34 of 35 people in the group

CDC biomonitoring results

  • geometric mean: 3.77 ng/g (lipid weight) in blood serum
  • found in 759 of 4821 people in the group
0 ng/g (lipid weight) in blood serum 51


PCB-183 results


Detailed toxicity classifications (References)

classification governing entity/references
Nervous system toxicity - weight of evidence unknown/unassessedATSDR (2000). Toxicological profile for polychlorinated biphenyls (PCBs): Health effects chapter. http://www.atsdr.cdc.gov/tfacts17.html
Limited evidence in humans - immune system toxicityATSDR (2000). Toxicological profile for polychlorinated biphenyls (PCBs): Health effects chapter. http://www.atsdr.cdc.gov/tfacts17.html